KEGG   ENZYME: 2.1.1.28Help
Entry
EC 2.1.1.28                 Enzyme                                 

Name
phenylethanolamine N-methyltransferase;
noradrenaline N-methyltransferase;
noradrenalin N-methyltransferase;
norepinephrine methyltransferase;
norepinephrine N-methyltransferase;
phenethanolamine methyltransferase;
phenethanolamine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine [RN:R04033]
Reaction(KEGG)
R04033;
(other) R02533
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Substrate
S-adenosyl-L-methionine [CPD:C00019];
phenylethanolamine [CPD:C02735]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N-methylphenylethanolamine [CPD:C03711]
Comment
Acts on various phenylethanolamines; converts noradrenaline into adrenaline.
History
EC 2.1.1.28 created 1972
Pathway
Tyrosine metabolism
Metabolic pathways
Orthology
K00553  
phenylethanolamine N-methyltransferase
Genes
HSA: 
5409(PNMT)
PTR: 
454634(PNMT)
PPS: 
100978896(PNMT)
GGO: 
101140487(PNMT)
PON: 
100450669(PNMT)
MCC: 
697444(PNMT)
MCF: 
102144850(PNMT)
MMU: 
18948(Pnmt)
RNO: 
24661(Pnmt)
CGE: 
HGL: 
101706187(Pnmt)
TUP: 
102501155(PNMT)
CFA: 
491023(PNMT)
AML: 
FCA: 
101101350(PNMT)
PTG: 
102961408(PNMT)
BTA: 
281413(PNMT)
BOM: 
102267416(PNMT)
PHD: 
102319588(PNMT)
CHX: 
102175988(PNMT)
SSC: 
100144479(PNMT)
CFR: 
102520076(PNMT)
ECB: 
100033859(PNMT)
MYB: 
102249392(PNMT)
MYD: 
102758984(PNMT)
PALE: 
MDO: 
100017260(PNMT)
SHR: 
100928301(PNMT)
OAA: 
100079586(PNMT)
GGA: 
100858738(PNMT)
TGU: 
100228437(PNMT)
FAB: 
101806263(PNMT)
PHI: 
102110801(PNMT)
FPG: 
101914742(PNMT)
CLV: 
102096197(PNMT)
ASN: 
102370069(PNMT)
PSS: 
102456862(PNMT)
CMY: 
102946470(PNMT)
ACS: 
XTR: 
100492236(pnmt)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102365914(PNMT)
 » show all
Taxonomy
Reference
1  [PMID:13863458]
  Authors
AXELROD J.
  Title
Purification and properties of phenylethanolamine-N-methyl transferase.
  Journal
J. Biol. Chem. 237 (1962) 1657-60.
  Organism
Macaca mulatta
Reference
2  [PMID:5412063]
  Authors
Connett RJ, Kirshner N.
  Title
Purification and properties of bovine phenylethanolamine N-methyltransferase.
  Journal
J. Biol. Chem. 245 (1970) 329-34.
  Organism
Bos taurus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9037-68-7

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