KEGG   ENZYME: 2.1.1.28Help
Entry
EC 2.1.1.28                 Enzyme                                 
Name
phenylethanolamine N-methyltransferase;
noradrenaline N-methyltransferase;
noradrenalin N-methyltransferase;
norepinephrine methyltransferase;
norepinephrine N-methyltransferase;
phenethanolamine methyltransferase;
phenethanolamine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine [RN:R04033]
Reaction(KEGG)
R04033;
(other) R02533
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Substrate
S-adenosyl-L-methionine [CPD:C00019];
phenylethanolamine [CPD:C02735]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N-methylphenylethanolamine [CPD:C03711]
Comment
Acts on various phenylethanolamines; converts noradrenaline into adrenaline.
Pathway
Tyrosine metabolism
Metabolic pathways
Orthology
K00553  
phenylethanolamine N-methyltransferase
Genes
HSA: 
5409(PNMT)
PTR: 
454634(PNMT)
PPS: 
100978896(PNMT)
GGO: 
101140487(PNMT)
PON: 
100450669(PNMT)
MCC: 
697444(PNMT)
MMU: 
18948(Pnmt)
RNO: 
24661(Pnmt)
CFA: 
491023(PNMT)
AML: 
FCA: 
101101350(PNMT)
BTA: 
281413(PNMT)
SSC: 
100144479(PNMT)
ECB: 
100033859(PNMT)
MDO: 
100017260
SHR: 
100928301(PNMT)
OAA: 
100079586
GGA: 
100858738
TGU: 
100228437(PNMT)
ACS: 
100565710
XTR: 
100492236
DRE: 
100332609
TRU: 
101068284
OLA: 
101172030
 » show all
Taxonomy
Reference
1  [PMID:13863458]
  Authors
AXELROD J.
  Title
Purification and properties of phenylethanolamine-N-methyl transferase.
  Journal
J. Biol. Chem. 237 (1962) 1657-60.
  Organism
Macaca mulatta [GN:mcc]
Reference
2  [PMID:5412063]
  Authors
Connett RJ, Kirshner N.
  Title
Purification and properties of bovine phenylethanolamine N-methyltransferase.
  Journal
J. Biol. Chem. 245 (1970) 329-34.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9037-68-7
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