KEGG   ENZYME: 2.1.1.5Help
Entry
EC 2.1.1.5                  Enzyme                                 

Name
betaine---homocysteine S-methyltransferase;
betaine-homocysteine methyltransferase;
betaine-homocysteine transmethylase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
trimethylammonioacetate:L-homocysteine S-methyltransferase
Reaction(IUBMB)
betaine + L-homocysteine = dimethylglycine + L-methionine [RN:R02821]
Reaction(KEGG)
Substrate
betaine [CPD:C00719];
L-homocysteine [CPD:C00155]
Product
dimethylglycine [CPD:C01026];
L-methionine [CPD:C00073]
History
EC 2.1.1.5 created 1961
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K00544  betaine-homocysteine S-methyltransferase
Genes
HSA: 635(BHMT)
PTR: 461786(BHMT)
PPS: 100985336(BHMT)
GGO: 101138811(BHMT)
PON: 100174207(BHMT)
NLE: 100588814(BHMT)
MCC: 714363(BHMT)
MCF: 102117049(BHMT)
CSAB: 103223581(BHMT)
RRO: 104662970(BHMT)
RBB: 108528900(BHMT)
CJC: 100393375(BHMT)
SBQ: 101049322(BHMT)
MMU: 12116(Bhmt)
RNO: 81508(Bhmt)
CGE: 100754488(Bhmt)
NGI: 103750287(Bhmt)
HGL: 101723121(Bhmt)
CCAN: 109675223(Bhmt)
OCU: 100339955(BHMT)
TUP: 102489167(BHMT)
CFA: 479171(BHMT)
AML: 100465664(BHMT)
UMR: 103681460(BHMT)
ORO: 101373012(BHMT)
FCA: 101085179(BHMT)
PTG: 102955687(BHMT)
AJU: 106974816
BTA: 497025(BHMT)
BOM: 102286920(BHMT)
BIU: 109564665(BHMT)
PHD: 102328254(BHMT)
CHX: 102175297(BHMT)
OAS: 101113853(BHMT)
SSC: 397371(BHMT)
CFR: 102523171(BHMT)
CDK: 105084827(BHMT)
BACU: 103000437(BHMT)
LVE: 103081575(BHMT)
OOR: 101282223(BHMT)
ECB: 100073265
EPZ: 103548663(BHMT)
EAI: 106841179(BHMT)
MYB: 102252728(BHMT)
MYD: 102775016(BHMT)
HAI: 109381916(BHMT)
RSS: 109445646(BHMT)
PALE: 102887754(BHMT)
LAV: 100672133(BHMT)
TMU: 101354749
MDO: 100032615(BHMT)
SHR: 100927569
OAA: 100088080(BHMT)
GGA: 416371(BHMT)
MGP: 100541641
CJO: 107305933
APLA: 101802407(BHMT)
ACYG: 106042084
TGU: 100221623(BHMT)
GFR: 102044419(BHMT)
FAB: 101813460(BHMT)
PHI: 102112767(BHMT)
PMAJ: 107216432
CCW: 104695711
FPG: 101910450(BHMT)
FCH: 102048321(BHMT)
CLV: 102097034
EGZ: 104124900
ASN: 102378363(BHMT)
AMJ: 102561209(BHMT)
PSS: 102445649(BHMT)
CMY: 102947612(BHMT)
CPIC: 101937801(BHMT)
ACS: 100558455
PVT: 110073962(BHMT)
PBI: 103049200(BHMT)
GJA: 107117367
XLA: 495275(bhmt.L)
XTR: 496651(bhmt)
NPR: 108799975
DRE: 322228(bhmt)
SRX: 107717756 107724714(bhmt)
SANH: 107679462
IPU: 108279028
AMEX: 103034807
SASA: 100194600(bhmt) 106568115
ELS: 105015174
SFM: 108925116 108925117(bhmt)
LCM: 102351553(BHMT)
CMK: 103177766(bhmt)
CRG: 105329125
MYI: 110455538
HMG: 100206048
FPH: Fphi_0698
FPT: BZ13_1329
FPI: BF30_905
FPM: LA56_1471
FPX: KU46_649
FPZ: LA55_102
FPJ: LA02_579
FNA: OOM_0106
CSA: Csal_0065
DRT: Dret_2255
PUB: SAR11_1173(bhmT)
BBEV: BBEV_2151(yitJ-1)
OIH: OB0691
BSE: Bsel_2622
SERJ: SGUI_2075
BLIN: BLSMQ_2928
DCO: SAMEA4475696_1438(metH_1)
 » show all
Taxonomy
Reference
1  [PMID:14456704]
  Authors
KLEE WA, RICHARDS HH, CANTONI GL.
  Title
The synthesis of methionine by enzymic transmethylation. VII. Existence of two separate homocysteine methylpherases on mammalian liver.
  Journal
Biochim. Biophys. Acta. 54 (1961) 157-64.
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.5
IUBMB Enzyme Nomenclature: 2.1.1.5
ExPASy - ENZYME nomenclature database: 2.1.1.5
BRENDA, the Enzyme Database: 2.1.1.5
CAS: 9029-78-1

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