KEGG   ENZYME: 2.1.1.67Help
Entry
EC 2.1.1.67                 Enzyme                                 
Name thiopurine S-methyltransferase;
mercaptopurine methyltransferase;
thiopurine methyltransferase;
6-thiopurine transmethylase;
TPMT
Class Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname S-adenosyl-L-methionine:thiopurine S-methyltransferase
Reaction(IUBMB) S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine +
a thiopurine S-methylether [RN:R03701]
Reaction(KEGG) R03701 > R08236 R08239 R08246
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Substrate S-adenosyl-L-methionine [CPD:C00019];
thiopurine [CPD:C01756]
Product S-adenosyl-L-homocysteine [CPD:C00021];
thiopurine S-methylether [CPD:C16614]
Comment Also acts, more slowly, on thiopyrimidines and aromatic thiols. Not
identical with EC 2.1.1.9 thiol S-methyltransferase.
Pathway ec00983  Drug metabolism - other enzymes
Orthology K00569  thiopurine S-methyltransferase
Genes HSA: 7172(TPMT)
PTR: 471863(TPMT)
MCC: 704564(TPMT)
MMU: 22017(Tpmt)
RNO: 690050(Tpmt)
CFA: 403536(TPMT)
BTA: 511644(TPMT)
SSC: 100152807
ECB: 100034066(TPMT)
MDO: 100025242
OAA: 100077195
GGA: 420830(TPMT)
TGU: 100230777
XLA: 447769(tpmt)
XTR: 549164(tpmt)
DRE: 436842(MGC109981)
BFO: BRAFLDRAFT_199016
CIN: 100181136
SPU: 582278
ISC: IscW_ISCW000415
NVE: NEMVE_v1g238963
TAD: TRIADDRAFT_58745 TRIADDRAFT_58746 TRIADDRAFT_60802
YLI: YALI0E05467g
TPS: THAPSDRAFT_268911
XCC: XCC1394(tpmT)
XCB: XC_2843
XCA: xccb100_2903
XCV: XCV1496(tpmT)
XAC: XAC1439(tpmT)
VCH: VC1226
VCO: VC0395_A0849
VCM: VCM66_1181
VCJ: VCD_003121
VVU: VV1_2377
VVY: VV1964
VPA: VP1296
VHA: VIBHAR_02114
VSP: VS_1718
VEX: VEA_003701
VFI: VF_1512(tpm)
VFM: VFMJ11_1605
VSA: VSAL_I1814
PPR: PBPRA1684
PAE: PA2832(tpm)
PAU: PA14_27460(tpm)
PAP: PSPA7_2323(tpm)
PAG: PLES_22331(tpm)
PPU: PP_1870(tpm)
PPF: Pput_3845
PPG: PputGB1_1445
PPW: PputW619_1479
PST: PSPTO_1777(tpm)
PSB: Psyr_3617
PFL: PFL_4249
PFO: Pfl01_3985
PFS: PFLU1728(tpm)
PEN: PSEEN1581(tpm)
PMY: Pmen_2525
PSA: PST_1312(tpmA) PST_2541
AVN: Avin_15380
PCR: Pcryo_1333 Pcryo_2081 Pcryo_2244
PRW: PsycPRwf_0288
ACI: ACIAD2922(tpm)
SON: SO_0582(tpm)
SDN: Sden_0541
SFR: Sfri_3498
SAZ: Sama_0543
SBL: Sbal_0541
SBM: Shew185_3784
SBN: Sbal195_3910
SBP: Sbal223_3727
SLO: Shew_3261
SPC: Sputcn32_3296
SSE: Ssed_4010
SPL: Spea_0588
SHE: Shewmr4_0581
SHM: Shewmr7_3449
SHN: Shewana3_0580
SHW: Sputw3181_0645
SHL: Shal_0675
SWD: Swoo_3438 Swoo_4153
SWP: swp_4515
SVO: SVI_3702(tpm)
CPS: CPS_3096
PAT: Patl_1524
MAQ: Maqu_3055
AMC: MADE_02272
TTU: TERTU_2055
LPN: lpg2835(tpm)
LPF: lpl2747
LPP: lpp2892
LPC: LPC_3119(tpm)
LPA: lpa_04116
MCA: MCA0794
FTU: FTT_1661(tmpT)
FTF: FTF1661(tmpT)
FTW: FTW_1959
FTL: FTL_0032
FTH: FTH_0031(tpmT)
FTA: FTA_0039
FTM: FTM_0011(tmpT)
FTN: FTN_0023(tmpT)
FPH: Fphi_0803
TCX: Tcr_1758
ALV: Alvin_1548
HCH: HCH_01328
CSA: Csal_2332
MMW: Mmwyl1_1365
AHA: AHA_1996(tpm)
ASA: ASA_1874(tpm)
TAU: Tola_1476
KKO: Kkor_0779
GPB: HDN1F_05740(tpm)
REH: H16_A0449
BPE: BP0873(tpm)
BPA: BPP2160(tpm)
BBR: BB1557(tpm)
BPT: Bpet3841(tpm)
BAV: BAV1018(tpm)
HSE: Hsero_3797(tpm)
NET: Neut_2272
NMU: Nmul_A2259
DAR: Daro_0514
MMB: Mmol_2155
MEH: M301_0221
MEI: Msip34_1933
SLT: Slit_1144
HOH: Hoch_2473
XAU: Xaut_2726
SNO: Snov_2584
GOX: GOX0680
APT: APA01_14450
MGM: Mmc1_0515
AMI: Amir_2144
LBJ: LBJ_0800
SLI: Slin_6497
GFO: GFO_2405(tpm)
SYX: SynWH7803_0885
HAU: Haur_3057
NDE: NIDE2804(tpm)
Taxonomy
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:13981612]
REMY CN.
Metabolism of thiopyrimidines and thiopurines. S-Methylation with
S-adenosylmethionine transmethylase and catabolism in mammalian
tissues.
J. Biol. Chem. 238 (1963) 1078-84.
Rattus norvegicus [GN:rno], Escherichia coli [GN:eco]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:6633508]
Woodson LC, Ames MM, Selassie CD, Hansch C, Weinshilboum RM.
Thiopurine methyltransferase. Aromatic thiol substrates and
inhibition by benzoic acid derivatives.
Mol. Pharmacol. 24 (1983) 471-8.
Homo sapiens [GN:hsa]
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:6838629]
Woodson LC, Weinshilboum RM.
Human kidney thiopurine methyltransferase. Purification and
biochemical properties.
Biochem. Pharmacol. 32 (1983) 819-26.
Homo sapiens [GN:hsa]
Other DBs ExplorEnz - The Enzyme Database: 2.1.1.67
IUBMB Enzyme Nomenclature: 2.1.1.67
ExPASy - ENZYME nomenclature database: 2.1.1.67
BRENDA, the Enzyme Database: 2.1.1.67
CAS: 67339-09-7
DBGET integrated database retrieval system