KEGG   ENZYME: 2.1.1.85Help
Entry
EC 2.1.1.85                 Enzyme                                 

Name
protein-histidine N-methyltransferase;
protein methylase IV;
protein (histidine) methyltransferase;
actin-specific histidine methyltransferase;
S-adenosyl methionine:protein-histidine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine [RN:R02627]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
protein L-histidine [CPD:C00615]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
protein Ntau-methyl-L-histidine
Comment
Highly specific for histidine residues, for example, in actin.
History
EC 2.1.1.85 created 1989
Reference
1  [PMID:3801515]
  Authors
Vijayasarathy C, Rao BS.
  Title
Partial purification and characterisation of S-adenosylmethionine:protein-histidine N-methyltransferase from rabbit skeletal muscle.
  Journal
Biochim. Biophys. Acta. 923 (1987) 156-65.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
108022-17-9

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