EC                 Enzyme                                 

tetrahydromethanopterin S-methyltransferase;
tetrahydromethanopterin methyltransferase;
mtrA-H (gene names);
cmtA (gene name);
N5-methyltetrahydromethanopterin---coenzyme M methyltransferase;
5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase
Transferring one-carbon groups;
BRITE hierarchy
5-methyl-5,6,7,8-tetrahydromethanopterin:CoM 2-methyltransferase (Na+-transporting)
5-methyl-5,6,7,8-tetrahydromethanopterin + CoM + 2 Na+in = 5,6,7,8-tetrahydromethanopterin + 2-(methylsulfanyl)ethane-1-sulfonate + 2 Na+out [RN:R04347]
5-methyl-5,6,7,8-tetrahydromethanopterin [CPD:C04488];
CoM [CPD:C03576];
Na+ [CPD:C01330]
5,6,7,8-tetrahydromethanopterin [CPD:C01217];
2-(methylsulfanyl)ethane-1-sulfonate [CPD:C03920];
Na+ [CPD:C01330]
Involved in the formation of methane from CO2 in methanogenic archaea. The reaction involves the export of one or two sodium ions. The enzyme from the archaeon Methanobacterium thermoautotrophicum is a membrane-associated multienzyme complex composed of eight different subunits, and contains a 5'-hydroxybenzimidazolyl-cobamide prosthetic group, to which the methyl group is attached during the transfer. A soluble enzyme that is induced by the presence of CO has been reported as well [6].
EC created 1989, modified 2000, modified 2017
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
K00577  tetrahydromethanopterin S-methyltransferase subunit A
K00578  tetrahydromethanopterin S-methyltransferase subunit B
K00579  tetrahydromethanopterin S-methyltransferase subunit C
K00580  tetrahydromethanopterin S-methyltransferase subunit D
K00581  tetrahydromethanopterin S-methyltransferase subunit E
K00582  tetrahydromethanopterin S-methyltransferase subunit F
K00583  tetrahydromethanopterin S-methyltransferase subunit G
K00584  tetrahydromethanopterin S-methyltransferase subunit H
TEE: Tel_11320
SVA: SVA_2695
DAR: Daro_2280
DTI: Desti_0878 Desti_5438 Desti_5449
MCH: Mchl_5727
CID: P73_3963
MAG: amb1203
PKU: AUO94_00060
CACE: CACET_c34490(mtrH)
DSY: DSY3157
DHD: Dhaf_4327
AWO: Awo_c07520(mttA2)
TOC: Toce_1535
ACA: ACP_1207
LFC: LFE_1243
MMP: MMP1560(mtrE) MMP1561(mtrD) MMP1562(mtrC) MMP1563(mtrB) MMP1564(mtrA) MMP1565(or900) MMP1566(mtrG) MMP1567(mtrH)
MAC: MA_0269(mtrH) MA_0270(mtrG) MA_0271(mtrF) MA_0272(mtrA) MA_0273(mtrB) MA_0274(mtrC) MA_0275(mtrD) MA_0276(mtrE) MA_1804(mtxH) MA_1805(mtxA)
MBU: Mbur_1518(mtrH) Mbur_1519(mtrG) Mbur_1520(mtrF) Mbur_1521(mtrA) Mbur_1522(mtrB) Mbur_1523(mtrC) Mbur_1524(mtrD) Mbur_1525(mtrE) Mbur_2244
MCJ: MCON_1068(mtrH) MCON_1069(mtrG) MCON_1070(mtrF) MCON_1071(mtrA) MCON_1072(mtrB) MCON_1073(mtrC) MCON_1074(mtrD) MCON_1075(mtrE) MCON_2872 MCON_2873
MBG: BN140_1739(mtrE) BN140_1740(mtrD) BN140_1741(mtrC) BN140_1742(mtrB) BN140_1743(mtrA1) BN140_1744(mtrF) BN140_1745(mtrA2) BN140_1746(mtrH)
MPD: MCP_0539(mtrE) MCP_0540(mtrD) MCP_0541(mtrC) MCP_0542(mtrB) MCP_0543(mtrA-1) MCP_0544(mtrF) MCP_0545(mtrG) MCP_0546(mtrH) MCP_0678(mtrA-2)
MEZ: Mtc_0936(mtrE) Mtc_0937(mtrD) Mtc_0938(mtrC) Mtc_0939(mtrB) Mtc_0940(mtrA-1) Mtc_0941(mtrF) Mtc_0942(mtrG) Mtc_0943(mtrH) Mtc_0962(mtrA-2)
RCI: RCIX2064(mtrE) RCIX2065(mtrD) RCIX2066(mtrC) RCIX2067(mtrB) RCIX2068(mtrA-1) RCIX2069(mtrA-2) RCIX2070(mtrG) RCIX2071(mtrH)
MWO: MWSIV6_1448(mtrA2) MWSIV6_1548(mtrH) MWSIV6_1549(mtrG) MWSIV6_1550(mtrF) MWSIV6_1551(mtrA1) MWSIV6_1552(mtrB) MWSIV6_1553(mtrC) MWSIV6_1554(mtrD) MWSIV6_1555(mtrE)
MST: Msp_0300(mtrE) Msp_0301(mtrD) Msp_0302(mtrC) Msp_0303(mtrB) Msp_0304(mtrA) Msp_0305(mtrF) Msp_0306(mtrG) Msp_0307(mtrH)
MRU: mru_0441(mtrA2) mru_1916(mtrH) mru_1917(mtrG) mru_1918(mtrF) mru_1919(mtrA1) mru_1920(mtrB) mru_1921(mtrC) mru_1922(mtrD) mru_1923(mtrE)
MEB: Abm4_1518(mtrH) Abm4_1519(mtrG) Abm4_1520(mtrF) Abm4_1521(mtrA) Abm4_1522(mtrB) Abm4_1523(mtrC) Abm4_1524(mtrD) Abm4_1525(mtrE)
MMIL: sm9_0659(mtrA2) sm9_1915(mtrH2) sm9_2019(mtrH1) sm9_2020(mtrG) sm9_2021(mtrF) sm9_2022(mtrA1) sm9_2023(mtrB) sm9_2024(mtrC) sm9_2025(mtrD) sm9_2026(mtrE)
MFC: BRM9_0927(mtrH) BRM9_0928(mtrG) BRM9_0929(mtrF) BRM9_0930(mtrA1) BRM9_0931(mtrB) BRM9_0932(mtrC) BRM9_0933(mtrD) BRM9_0934(mtrE) BRM9_1713(mtrA2) BRM9_2057(mtrA3)
MCUB: MCBB_1144(mtrA2) MCBB_1977(mtrH) MCBB_1978(mtrG) MCBB_1979(mtrF) MCBB_1980(mtrA1) MCBB_1981(mtrB) MCBB_1982(mtrC) MCBB_1983(mtrD) MCBB_1984(mtrE)
MKA: MK0656(mtrE) MK0657(mtrD) MK0658(mtrC) MK0659(mtrB) MK0660(mtrA) MK0661(mtrG) MK0662(mtrH) MK1485(mtrF)
GAC: GACE_1353
GAH: GAH_01245
HALH: HTSR_1745(mtrH)
HHSR: HSR6_1811(mtrH)
SMR: Smar_0413
IAG: Igag_0398
NMR: Nmar_1747
NCT: NMSP_1666(mtrA1)
NEV: NTE_01720
NCV: NCAV_0248
NDV: NDEV_2077
KCR: Kcr_0196
BARC: AOA65_0679(mtrH_1) AOA65_1010(mtrH_2) AOA65_2047(mtrH_3)
LOKI: Lokiarch_10270(mtrH_1) Lokiarch_42890(mtrH_2) Lokiarch_51490(mtrH_3)
 » show all
1  [PMID:3085670]
Sauer FD.
Tetrahydromethanopterin methyltransferase, a component of the methane synthesizing complex of Methanobacterium thermoautotrophicum.
Biochem. Biophys. Res. Commun. 136 (1986) 542-7.
2  [PMID:8477726]
Gartner P, Ecker A, Fischer R, Linder D, Fuchs G, Thauer RK
Purification and properties of N5-methyltetrahydromethanopterin:coenzyme M methyltransferase from Methanobacterium thermoautotrophicum.
Eur. J. Biochem. 213 (1993) 537-45.
3  [PMID:7813469]
Weiss DS, Gartner P, Thauer RK
The energetics and sodium-ion dependence of N5-methyltetrahydromethanopterin:coenzyme M methyltransferase studied with cob(I)alamin as methyl acceptor and methylcob(III)alamin as methyl donor.
Eur. J. Biochem. 226 (1994) 799-809.
4  [PMID:7737157]
Harms U, Weiss DS, Gartner P, Linder D, Thauer RK
The energy conserving N5-methyltetrahydromethanopterin:coenzyme M methyltransferase complex from Methanobacterium thermoautotrophicum is composed of eight different subunits.
Eur. J. Biochem. 228 (1995) 640-8.
5  [PMID:11248186]
Gottschalk G, Thauer RK
The Na(+)-translocating methyltransferase complex from methanogenic archaea.
Biochim. Biophys. Acta. 1505 (2001) 28-36.
6  [PMID:22636775]
Vepachedu VR, Ferry JG
Role of the fused corrinoid/methyl transfer protein CmtA during CO-dependent growth of Methanosarcina acetivorans.
J. Bacteriol. 194 (2012) 4161-8.
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
UM-BBD (Biocatalysis/Biodegradation Database):
BRENDA, the Enzyme Database:
CAS: 103406-60-6

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