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Entry
EC 2.1.1.86                 Enzyme                                 

Name
tetrahydromethanopterin S-methyltransferase;
tetrahydromethanopterin methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase
Reaction(IUBMB)
5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate [RN:R04347]
Reaction(KEGG)
Substrate
5-methyl-5,6,7,8-tetrahydromethanopterin [CPD:C04488];
2-mercaptoethanesulfonate [CPD:C03576]
Product
5,6,7,8-tetrahydromethanopterin [CPD:C01217];
2-(methylthio)ethanesulfonate [CPD:C03920]
Comment
Involved in the formation of methane from CO in Methanobacterium thermoautotrophicum. Methanopterin is a pterin analogue. The reaction involves the export of one or two sodium ions in Archaea.
History
EC 2.1.1.86 created 1989, modified 2000
Pathway
Methane metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K00577  
tetrahydromethanopterin S-methyltransferase subunit A
K00578  
tetrahydromethanopterin S-methyltransferase subunit B
K00579  
tetrahydromethanopterin S-methyltransferase subunit C
K00580  
tetrahydromethanopterin S-methyltransferase subunit D
K00581  
tetrahydromethanopterin S-methyltransferase subunit E
K00582  
tetrahydromethanopterin S-methyltransferase subunit F
K00583  
tetrahydromethanopterin S-methyltransferase subunit G
K00584  
tetrahydromethanopterin S-methyltransferase subunit H
Genes
TEE: 
DAR: 
DTI: 
MCH: 
HMC: 
CID: 
MAG: 
PKU: 
CACE: 
DSY: 
DHD: 
DDH: 
DKU: 
TJR: 
DOR: 
DMI: 
DED: 
DEC: 
DRS: 
AWO: 
Awo_c07520(mttA2)
TOC: 
ACA: 
LFC: 
LFI: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMP1560(mtrE) MMP1561(mtrD) MMP1562(mtrC) MMP1563(mtrB) MMP1564(mtrA) MMP1565(or900) MMP1566(mtrG) MMP1567(mtrH)
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MA_0269(mtrH) MA_0270(mtrG) MA_0271(mtrF) MA_0272(mtrA) MA_0273(mtrB) MA_0274(mtrC) MA_0275(mtrD) MA_0276(mtrE) MA_1805(mtxA)
MBA: 
MBY: 
MBW: 
MBAR: 
MMA: 
MMAZ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
Mbur_1518(mtrH) Mbur_1519(mtrG) Mbur_1520(mtrF) Mbur_1521(mtrA) Mbur_1522(mtrB) Mbur_1523(mtrC) Mbur_1524(mtrD) Mbur_1525(mtrE) Mbur_2244
MMET: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
BN140_1739(mtrE) BN140_1740(mtrD) BN140_1741(mtrC) BN140_1742(mtrB) BN140_1743(mtrA1) BN140_1744(mtrF) BN140_1745(mtrA2) BN140_1746(mtrH)
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MCP_0539(mtrE) MCP_0540(mtrD) MCP_0541(mtrC) MCP_0542(mtrB) MCP_0543(mtrA-1) MCP_0544(mtrF) MCP_0545(mtrG) MCP_0546(mtrH) MCP_0678(mtrA-2)
MEZ: 
Mtc_0936(mtrE) Mtc_0937(mtrD) Mtc_0938(mtrC) Mtc_0939(mtrB) Mtc_0940(mtrA-1) Mtc_0941(mtrF) Mtc_0942(mtrG) Mtc_0943(mtrH) Mtc_0962(mtrA-2)
RCI: 
RCIX2064(mtrE) RCIX2065(mtrD) RCIX2066(mtrC) RCIX2067(mtrB) RCIX2068(mtrA-1) RCIX2069(mtrA-2) RCIX2070(mtrG) RCIX2071(mtrH)
MTH: 
MMG: 
METC: 
MST: 
Msp_0300(mtrE) Msp_0301(mtrD) Msp_0302(mtrC) Msp_0303(mtrB) Msp_0304(mtrA) Msp_0305(mtrF) Msp_0306(mtrG) Msp_0307(mtrH)
MSI: 
MRU: 
mru_0441(mtrA2) mru_1916(mtrH) mru_1917(mtrG) mru_1918(mtrF) mru_1919(mtrA1) mru_1920(mtrB) mru_1921(mtrC) mru_1922(mtrD) mru_1923(mtrE)
MEB: 
Abm4_1518(mtrH) Abm4_1519(mtrG) Abm4_1520(mtrF) Abm4_1521(mtrA) Abm4_1522(mtrB) Abm4_1523(mtrC) Abm4_1524(mtrD) Abm4_1525(mtrE)
MMIL: 
sm9_0659(mtrA2) sm9_1915(mtrH2) sm9_2019(mtrH1) sm9_2020(mtrG) sm9_2021(mtrF) sm9_2022(mtrA1) sm9_2023(mtrB) sm9_2024(mtrC) sm9_2025(mtrD) sm9_2026(mtrE)
MEYE: 
MEL: 
MEW: 
METH: 
MFC: 
BRM9_0927(mtrH) BRM9_0928(mtrG) BRM9_0929(mtrF) BRM9_0930(mtrA1) BRM9_0931(mtrB) BRM9_0932(mtrC) BRM9_0933(mtrD) BRM9_0934(mtrE) BRM9_1713(mtrA2) BRM9_2057(mtrA3)
MFI: 
MFV: 
MKA: 
MK0656(mtrE) MK0657(mtrD) MK0658(mtrC) MK0659(mtrB) MK0660(mtrA) MK0661(mtrG) MK0662(mtrH) MK1485(mtrF)
AFG: 
AST: 
FPL: 
GAC: 
GAH: 
SMR: 
SHC: 
IAG: 
THG: 
NMR: 
NIR: 
NID: 
NIN: 
NKR: 
CSY: 
NGA: 
NVN: 
NEV: 
TAA: 
TAH: 
KCR: 
LOKI: 
BARC: 
AOA65_0679(mtrH_1) AOA65_1010(mtrH_2) AOA65_2047(mtrH_3)
 » show all
Taxonomy
Reference
1  [PMID:3085670]
  Authors
Sauer FD.
  Title
Tetrahydromethanopterin methyltransferase, a component of the methane synthesizing complex of Methanobacterium thermoautotrophicum.
  Journal
Biochem. Biophys. Res. Commun. 136 (1986) 542-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
103406-60-6

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