KEGG   ENZYME: 2.1.1.89Help
Entry
EC 2.1.1.89                 Enzyme                                 

Name
tetrahydrocolumbamine 2-O-methyltransferase;
tetrahydrocolumbamine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl-L-homocysteine + tetrahydropalmatine [RN:R04077]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
5,8,13,13a-tetrahydrocolumbamine [CPD:C04118]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
tetrahydropalmatine [CPD:C02890]
Comment
Involved in the biosynthesis of the berberine alkaloids.
History
EC 2.1.1.89 created 1989
Pathway
Isoquinoline alkaloid biosynthesis
Reference
1
  Authors
Beecher, C.W.W. and Kelleher, W.J.
  Title
Enzymatic study of the late stages of protoberberine alkaloid biosynthesis.
  Journal
Tetrahedron Lett. 25 (1984) 4595-4598.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
93792-09-7

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