KEGG   ENZYME: 2.1.1.95Help
Entry
EC 2.1.1.95                 Enzyme                                 

Name
tocopherol O-methyltransferase;
gamma-tocopherol methyltransferase;
VTE4 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol  [RN:R07236];
(2) S-adenosyl-L-methionine + delta-tocopherol = S-adenosyl-L-homocysteine + beta-tocopherol  [RN:R07504];
(3) S-adenosyl-L-methionine + gamma-tocotrienol = S-adenosyl-L-homocysteine + alpha-tocotrienol  [RN:R10491];
(4) S-adenosyl-L-methionine + delta-tocotrienol = S-adenosyl-L-homocysteine + beta-tocotrienol [RN:R10492]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
gamma-tocopherol [CPD:C02483];
delta-tocopherol [CPD:C14151];
gamma-tocotrienol [CPD:C14155];
delta-tocotrienol [CPD:C14156]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
alpha-tocopherol [CPD:C02477];
beta-tocopherol [CPD:C14152];
alpha-tocotrienol [CPD:C14153];
beta-tocotrienol [CPD:C14154]
Comment
The enzymes from plants and photosynthetic bacteria have similar efficiency with the gamma and delta isomers of tocopherols and tocotrienols.
History
EC 2.1.1.95 created 1989, modified 2013
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K05928  
tocopherol O-methyltransferase
Genes
ATH: 
AT1G64970(G-TMT)
ALY: 
CRB: 
EUS: 
BRP: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0013s07440g(POPTRDRAFT_807031)
VVI: 
SLY: 
778248(TMT)
SOT: 
102577815(GAMMA-TMT)
OSA: 
DOSA: 
Os02t0701600-01(Os02g0701600)
OBR: 
BDI: 
SBI: 
SORBI_04g030760(SORBIDRAFT_04g030760) SORBI_05g024740(SORBIDRAFT_05g024740) SORBI_08g001960(SORBIDRAFT_08g001960)
ZMA: 
732837(cl364_1)
SITA: 
PDA: 
MUS: 
ATR: 
s00048p00220930(AMTR_s00048p00220930) s00048p00222210(AMTR_s00048p00222210)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
CME: 
GSL: 
CCP: 
BFU: 
MBE: 
PTI: 
TPS: 
EHX: 
GTT: 
RVA: 
PGM: 
ART: 
APN: 
SESP: 
CAI: 
SYN: 
slr0089(erg6)
SYZ: 
SYY: 
SYNGTS_2600(slr0089)
SYT: 
SYNGTI_2599(slr0089)
SYS: 
SYNPCCN_2598(slr0089)
SYQ: 
SYNPCCP_2598(slr0089)
SYJ: 
SYP: 
CYA: 
CYB: 
SYNE: 
SYNP: 
MAR: 
CYT: 
CYP: 
CYC: 
CYN: 
CYH: 
CYJ: 
AMR: 
DSL: 
HAO: 
GLP: 
CMP: 
TER: 
LEP: 
GEI: 
OAC: 
ONI: 
PSEU: 
CEP: 
MIC: 
ARP: 
GVI: 
GLJ: 
GKIL_0804(ubiE)
ANA: 
NPU: 
NOS: 
NOP: 
AVA: 
ANB: 
ACY: 
NAZ: 
CSG: 
CALO: 
CALT: 
RIV: 
CTHE: 
PLP: 
SCS: 
TRA: 
 » show all
Taxonomy
Reference
1
  Authors
Camara, B. and D'Harlingue, A.
  Title
Demonstration and solubilization of S-adenosylmethionine - gamma-tocopherol methyltransferase from capsicum chromoplasts.
  Journal
Plant Cell Rep. 4 (1985) 31-32.
Reference
2  [PMID:12492478]
  Authors
Koch M, Lemke R, Heise KP, Mock HP
  Title
Characterization of gamma-tocopherol methyltransferases from Capsicum annuum L and Arabidopsis thaliana.
  Journal
Eur. J. Biochem. 270 (2003) 84-92.
Reference
3  [PMID:22763462]
  Authors
Zhang GY, Liu RR, Xu G, Zhang P, Li Y, Tang KX, Liang GH, Liu QQ
  Title
Increased alpha-tocotrienol content in seeds of transgenic rice overexpressing Arabidopsis gamma-tocopherol methyltransferase.
  Journal
Transgenic. Res. 22 (2013) 89-99.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
84788-82-9

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