diphthine synthase;
S-adenosyl-L-methionine:elongation factor 2 methyltransferase;
diphthine methyltransferase

Transferases;
Transferring one-carbon groups;
Methyltransferases

S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase

S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine [RN:R04481]

R04481;
(other) R08468 R08469

S-adenosyl-L-methionine [CPD:C00019];
2-(3-carboxy-3-aminopropyl)-L-histidine [CPD:C04441]

2-[3-Carboxy-3-(methylammonio)propyl]-L-histidine and the corresponding dimethyl compound can also act as acceptors; the trimethylated product, diphthine, is converted into diphthamide by EC 6.3.2.22 diphthine---ammonia ligase.

1  [PMID:3042777]

Chen JY, Bodley JW.

Biosynthesis of diphthamide in Saccharomyces cerevisiae. Partial purification and characterization of a specific S-adenosylmethionine:elongation factor 2 methyltransferase.

J. Biol. Chem. 263 (1988) 11692-6.

Saccharomyces cerevisiae [GN:sce]

2  [PMID:3346227]

Moehring JM, Moehring TJ.

The post-translational trimethylation of diphthamide studied in vitro.

J. Biol. Chem. 263 (1988) 3840-4.

Homo sapiens [GN:hsa], Mus musculus [GN:mmu], Rattus norvegicus [GN:rno], Bos taurus [GN:bta], Gallus gallus [GN:gga], Saccharomyces cerevisiae [GN:sce], Cercopithecus aethiops, Oryctolagus cuniculus, Cricetulus griseus, Mesocricetus auratus, Muntiacus muntjak, Notopthalmus viridescens, Porthetria dispar, Triticum aestivum, Schizophyllum commune