KEGG   ENZYME: 2.1.4.1Help
Entry
EC 2.1.4.1                  Enzyme                                 

Name
glycine amidinotransferase;
arginine-glycine amidinotransferase;
arginine-glycine transamidinase;
glycine transamidinase
Class
Transferases;
Transferring one-carbon groups;
Amidinotransferases
BRITE hierarchy
Sysname
L-arginine:glycine amidinotransferase
Reaction(IUBMB)
L-arginine + glycine = L-ornithine + guanidinoacetate [RN:R00565]
Reaction(KEGG)
R00565;
(other) R01686 R01989
Show
Substrate
L-arginine [CPD:C00062];
glycine [CPD:C00037]
Product
L-ornithine [CPD:C00077];
guanidinoacetate [CPD:C00581]
Comment
Canavanine can act instead of arginine.
History
EC 2.1.4.1 created 1961 as EC 2.6.2.1, transferred 1965 to EC 2.1.4.1
Pathway
Glycine, serine and threonine metabolism
Arginine and proline metabolism
Metabolic pathways
Orthology
K00613  
glycine amidinotransferase
Genes
HSA: 
2628(GATM)
PTR: 
453401(GATM)
PPS: 
100982293(GATM)
GGO: 
101144802(GATM)
PON: 
100171513(GATM)
MCC: 
713306(GATM)
MCF: 
102138299(GATM)
MMU: 
67092(Gatm)
RNO: 
81660(Gatm)
CGE: 
100771783(Gatm)
HGL: 
101696418(Gatm)
TUP: 
102470318(GATM)
CFA: 
414733(GATM)
AML: 
FCA: 
414734(GATM)
PTG: 
102969260(GATM)
BTA: 
414732(GATM)
BOM: 
102274253(GATM)
PHD: 
102332910(GATM)
CHX: 
102184628(GATM)
SSC: 
100126844(GATM)
CFR: 
102507646(GATM)
BACU: 
103002160(GATM)
LVE: 
103073454(GATM)
ECB: 
100070511(GATM)
MYB: 
102241381(GATM)
MYD: 
102770940(GATM)
PALE: 
102894268(GATM)
MDO: 
100012229(GATM)
SHR: 
100933609(GATM)
OAA: 
100073477(GATM)
GGA: 
395504(GATM)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
379386(gatm)
XTR: 
394568(gatm)
DRE: 
266799(gatm)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103186480(gatm)
BFO: 
CIN: 
SPU: 
SMM: 
NVE: 
AQU: 
SMP: 
MAW: 
MAJ: 
CMT: 
CIM: 
CPW: 
URE: 
PIF: 
EPY: 
EpC_01150(hsvA) EpC_31010(hsvA)
EPR: 
EAM: 
EAMY_0520(hsvA)
EAY: 
EAM_2910(hsvA)
ERJ: 
PLU: 
PAY: 
XNE: 
PPR: 
PST: 
PSP: 
SHL: 
PSY: 
LHK: 
BGD: 
SCU: 
RIR: 
BJA: 
BJU: 
NWI: 
MEX: 
MEA: 
MDI: 
METDI4255(gatm)
MCH: 
MRD: 
MET: 
MPO: 
BID: 
MSC: 
JAN: 
RDE: 
RD1_1472(gatM)
PUB: 
APM: 
SBH: 
SDV: 
SRC: 
SALU: 
PAC: 
PAK: 
PAV: 
PAX: 
PAZ: 
PAW: 
PAD: 
PCN: 
PACC: 
PACH: 
SEN: 
AMD: 
AMN: 
AMM: 
AMZ: 
AMI: 
KAL: 
SAQ: 
MCU: 
TPY: 
CWO: 
CCU: 
ELE: 
EYY: 
GPA: 
AEQ: 
BRM: 
BPO: 
BPJ: 
BPIP: 
BPW: 
SBR: 
MAR: 
CYN: 
AMR: 
TER: 
RIV: 
 » show all
Taxonomy
Reference
1
  Authors
Borsook, H. and Dubnoff, J.W.
  Title
The formation of glycocyamine in animal tissues.
  Journal
J. Biol. Chem. 138 (1941) 389-403.
Reference
2  [PMID:14304853]
  Authors
CONCONI F, GRAZI E.
  Title
TRANSAMIDINASE OF HOG KIDNEY. I. PURIFICATION AND PROPERTIES.
  Journal
J. Biol. Chem. 240 (1965) 2461-4.
  Organism
Sus scofa
Reference
3  [PMID:6766137]
  Authors
McGuire DM, Tormanen CD, Segal IS, Van Pilsum JF.
  Title
The effect of growth hormone and thyroxine on the amount of L-arginine:glycine amidinotransferase in kidneys of hypophysectomized rats. Purification and some properties of rat kidney transamidinase.
  Journal
J. Biol. Chem. 255 (1980) 1152-9.
  Organism
Rattus norvegicus
  Sequence
[rno:81660]
Reference
4
  Authors
Ratner, S.
  Title
Transamidination.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 267-275.
Reference
5  [PMID:13355454]
  Authors
RATNER S, ROCHOVANSKY O.
  Title
Biosynthesis of guanidinoacetic acid.  I.  Purification and properties of transamidinase.
  Journal
Arch. Biochem. Biophys. 63 (1956) 277-95.
  Organism
Rattus norvegicus
Reference
6  [PMID:13355455]
  Authors
RATNER S, ROCHOVANSKY O.
  Title
Biosynthesis of guanidinoacetic acid.  II.  Mechanism of amidine group transfer.
  Journal
Arch. Biochem. Biophys. 63 (1956) 296-315.
  Organism
Sus scofa
Reference
7  [PMID:13278360]
  Authors
WALKER JB.
  Title
Biosynthesis of arginine from canavanine and ornithine in kidney.
  Journal
J. Biol. Chem. 218 (1956) 549-56.
  Organism
Sus scofa
Reference
8  [PMID:13398387]
  Authors
WALKER JB.
  Title
Studies on the mechanism of action of kidney transamidinase.
  Journal
J. Biol. Chem. 224 (1957) 57-66.
  Organism
Rattus norvegicus, Sus scofa
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-35-4

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