KEGG   ENZYME: 2.3.1.169Help
Entry
EC 2.3.1.169                Enzyme                                 

Name
CO-methylating acetyl-CoA synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:corrinoid protein O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] [RN:R08433]
Reaction(KEGG)
R08433;
(other) R09317 R10243
Show
Substrate
acetyl-CoA [CPD:C00024];
[Co(I) corrinoid Fe-S protein]
Product
CO [CPD:C00237];
CoA [CPD:C00010];
[methyl-Co(III) corrinoid Fe-S protein]
Comment
Contains nickel, copper and iron-sulfur clusters. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin), in the synthesis of acetyl-CoA from CO2 and H2.
History
EC 2.3.1.169 created 2003, modified 2015
Pathway
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Orthology
K14138  
acetyl-CoA synthase
Genes
DAK: 
DSF: 
DOL: 
DAL: 
DAT: 
DTO: 
DAO: 
DTI: 
SFU: 
DBR: 
CLJ: 
CAH: 
CSQ: 
CACE: 
CCK: 
AMT: 
GFE: 
BYL: 
CDF: 
PDC: 
CDC: 
CDL: 
CDG: 
PDF: 
CST: 
DSY: 
DHD: 
DDH: 
DDL: 
DMT: 
DAE: 
DKU: 
DGI: 
DAU: 
TJR: 
DOR: 
DAI: 
DMI: 
DED: 
DEC: 
DRS: 
ELM: 
AWO: 
Awo_c10760(acsB1) Awo_c33680(acsB2)
TKI: 
CHY: 
CHY_1222(acsB)
TEP: 
TAE: 
MTA: 
ADG: 
TPZ: 
TOC: 
AAR: 
DET: 
DEH: 
cbdbA652(codH)
DEB: 
DEV: 
DhcVS_604(cdhC)
DEG: 
DMC: 
btf_622(acsB)
DMD: 
dcmb_668(acsB)
DMG: 
GY50_0591(cdhC)
DMX: 
DMY: 
DMZ: 
DUC: 
DLY: 
DEW: 
TAZ: 
TPI: 
TYE: 
TID: 
TOP: 
TCM: 
CTHI: 
MEMA: 
MER: 
 » show all
Taxonomy
Reference
1  [PMID:2984190]
  Authors
Ragsdale SW, Wood HG.
  Title
Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis.
  Journal
J. Biol. Chem. 260 (1985) 3970-7.
Reference
2  [PMID:12386327]
  Authors
Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL.
  Title
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.
  Journal
Science. 298 (2002) 567-72.
  Sequence
[mta:Moth_1202]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
176591-19-8

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