KEGG   ENZYME: 2.3.1.20Help
Entry
EC 2.3.1.20                 Enzyme                                 

Name
diacylglycerol O-acyltransferase;
diglyceride acyltransferase;
1,2-diacylglycerol acyltransferase;
diacylglycerol acyltransferase;
diglyceride O-acyltransferase;
palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase;
acyl-CoA:1,2-diacylglycerol O-acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
Reaction(IUBMB)
acyl-CoA + 1,2-diacyl-sn-glycerol = CoA + triacylglycerol [RN:R02251]
Reaction(KEGG)
R02251 > R02694;
(other) R09474
Show
Substrate
acyl-CoA [CPD:C00040];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
CoA [CPD:C00010];
triacylglycerol [CPD:C00422]
Comment
Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.
History
EC 2.3.1.20 created 1965
Pathway
Cutin, suberine and wax biosynthesis
Glycerolipid metabolism
Metabolic pathways
Orthology
K00635  
diacylglycerol O-acyltransferase
K11155  
diacylglycerol O-acyltransferase 1
K11160  
diacylglycerol O-acyltransferase 2
K14456  
2-acylglycerol O-acyltransferase 3
K15406  
wax-ester synthase / diacylglycerol O-acyltransferase
Genes
HSA: 
346606(MOGAT3) 84649(DGAT2) 8694(DGAT1)
PTR: 
464460(DGAT1) 466714(DGAT2) 472468(MOGAT3)
PPS: 
100969446(MOGAT3) 100987880(DGAT2) 100994391(DGAT1)
GGO: 
101124779(DGAT2) 101142898(DGAT1) 101150469(MOGAT3)
PON: 
100439588(MOGAT3) 100442216(DGAT2) 100453587(DGAT1)
MCC: 
MCF: 
102116598(MOGAT3) 102121566(DGAT1) 102128601(DGAT2)
MMU: 
13350(Dgat1) 67800(Dgat2)
RNO: 
252900(Dgat2) 84497(Dgat1)
CGE: 
HGL: 
101698712(Dgat2) 101723650(Dgat1)
TUP: 
102471587(MOGAT3) 102474487(DGAT1) 102494423(DGAT2)
CFA: 
482093(DGAT1) 485185(DGAT2) 608245(MOGAT3)
AML: 
FCA: 
101089413(MOGAT3) 101100329(DGAT2) 101101615(DGAT1)
BTA: 
282609(DGAT1) 404129(DGAT2) 618076(MOGAT3)
BOM: 
PHD: 
CHX: 
100861225(DGAT1) 102170308(MOGAT3) 102174409(DGAT2)
SSC: 
100294675(DGAT2) 100624333(MOGAT3) 397118(DGAT)
CFR: 
102504113(DGAT2) 102515256(DGAT1) 102519554(MOGAT3)
ECB: 
100060232(MOGAT3) 100064387(DGAT2) 100147359(DGAT1)
MYB: 
102249575(MOGAT3) 102261774(DGAT2) 102263903(DGAT1)
MDO: 
SHR: 
OAA: 
GGA: 
421309(DGAT2) 428693
TGU: 
100220095(DGAT2)
FAB: 
PHI: 
APLA: 
101801215(DGAT2)
FPG: 
FCH: 
CLV: 
ASN: 
PSS: 
ACS: 
XLA: 
398800(dgat2)
XTR: 
100127752(dgat2l6) 101730812(dgat1) 395003(dgat2)
DRE: 
325875(dgat1a) 565316(dgat2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
552377(mdy)
NVI: 
TCA: 
BMOR: 
PHU: 
ISC: 
CEL: 
CBR: 
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT2G19450(TAG1) AT5G37300(WSD1)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
GMX: 
547982(DGAT) 548005(DAGAT1)
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os05t0196800-00(Os05g0196800) Os06t0563900-01(Os06g0563900)
BDI: 
SBI: 
SORBI_09g006110(SORBIDRAFT_09g006110) SORBI_10g022270(SORBIDRAFT_10g022270)
ZMA: 
SITA: 
SMO: 
PPP: 
VCN: 
CSL: 
CVR: 
CME: 
GSL: 
CCP: 
YLI: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
VAL: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_1456054(AO090011000863)
ANG: 
ANI_1_1688104(An12g03600)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
ECU: 
EIN: 
EHE: 
NCE: 
MBR: 
DDI: 
DPP: 
DFA: 
ACAN: 
PFA: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
TAN: 
TPV: 
BBO: 
BBOV_IV004970(23.m06462)
CPV: 
CHO: 
TGO: 
TET: 
PTI: 
TPS: 
EHX: 
GTT: 
NGR: 
PAR: 
ACI: 
ACIAD0832(wax-dgaT)
ACB: 
ABM: 
ABSDF0686(wax-dgaT)
ABY: 
ABAYE0708(wax-dgaT)
ABO: 
ABO_1804(atfA2) ABO_2742(atfA1)
ADE: 
MMC: 
MJL: 
NCA: 
FRA: 
SUS: 
 » show all
Taxonomy
Reference
1  [PMID:947894]
  Authors
Coleman R, Bell RM.
  Title
Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols.
  Journal
J. Biol. Chem. 251 (1976) 4537-43.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:6289909]
  Authors
Grigor MR, Bell RM.
  Title
Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis.
  Journal
Biochim. Biophys. Acta. 712 (1982) 464-72.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:3422635]
  Authors
Kawasaki T, Snyder F.
  Title
Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells.
  Journal
J. Biol. Chem. 263 (1988) 2593-6.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:13843753]
  Authors
WEISS SB, KENNEDY EP, KIYASU JY.
  Title
The enzymatic synthesis of triglycerides.
  Journal
J. Biol. Chem. 235 (1960) 40-4.
  Organism
Gallus gallus [GN:gga]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-98-5

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