| Entry |
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| Name |
[acyl-carrier-protein] S-acetyltransferase;
acetyl coenzyme A-acyl-carrier-protein transacylase;
[acyl-carrier-protein]acetyltransferase;
[ACP]acetyltransferase;
ACAT;
acetyl-CoA:[acyl-carrier-protein] S-acetyltransferase
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
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| Sysname |
acetyl-CoA:[acyl-carrier protein] S-acetyltransferase
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| Reaction(IUBMB) |
acetyl-CoA + an [acyl-carrier protein] = CoA + an acetyl-[acyl-carrier protein] [RN: R01624]
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| Reaction(KEGG) |
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| Substrate |
acetyl-CoA [CPD: C00024];
[acyl-carrier protein] [CPD: C00229]
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| Product |
CoA [CPD: C00010];
acetyl-[acyl-carrier protein] [CPD: C03939]
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| Comment |
This enzyme, along with EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, is essential for the initiation of fatty-acid biosynthesis in bacteria. The substrate acetyl-CoA protects the enzyme against inhibition by N-ethylmaleimide or iodoacetamide [4]. This is one of the activities associated with beta-ketoacyl-ACP synthase III (EC 2.3.1.180) [5].
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| Reference |
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| Authors |
Prescott DJ, Vagelos PR. |
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| Title |
Acyl carrier protein. |
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| Journal |
Adv. Enzymol. Relat. Areas. Mol. Biol. 36 (1972) 269-311. |
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| Reference |
|
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| Authors |
Vance DE, Mitsuhashi O, Bloch K. |
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| Title |
Purification and properties of the fatty acid synthetase from Mycobacterium phlei. |
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| Journal |
J. Biol. Chem. 248 (1973) 2303-9. |
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| Organism |
Mycobacterium phlei |
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| Reference |
|
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| Authors |
Williamson IP, Wakil SJ. |
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| Title |
Studies on the mechanism of fatty acid synthesis. XVII. Preparation and general properties of acetyl coenzyme A and malonyl coenzyme A-acyl carrier protein transacylases. |
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| Journal |
J. Biol. Chem. 241 (1966) 2326-32. |
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| Organism |
Escherichia coli [GN: eco] |
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| Reference |
|
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| Authors |
Lowe PN, Rhodes S. |
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| Title |
Purification and characterization of [acyl-carrier-protein] acetyltransferase from Escherichia coli. |
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| Journal |
Biochem. J. 250 (1988) 789-96. |
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| Organism |
Escherichia coli [GN: eco] |
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| Reference |
|
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| Authors |
Tsay JT, Oh W, Larson TJ, Jackowski S, Rock CO. |
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| Title |
Isolation and characterization of the beta-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12. |
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| Journal |
J. Biol. Chem. 267 (1992) 6807-14. |
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| Organism |
Escherichia coli [GN: eco] |
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| Reference |
|
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| Authors |
Rangan VS, Smith S. |
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| Title |
Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA:acyl carrier protein S-acyltransferase domain of the multifunctional fatty acid synthase by mutation of a single arginine residue. |
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| Journal |
J. Biol. Chem. 272 (1997) 11975-8. |
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| Organism |
Escherichia coli [GN: eco] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37257-16-2 |
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