| Entry |
|
|---|
| Name |
arylamine N-acetyltransferase;
arylamine acetylase;
beta-naphthylamine N-acetyltransferase;
4-aminobiphenyl N-acetyltransferase;
acetyl CoA-arylamine N-acetyltransferase;
2-naphthylamine N-acetyltransferase;
arylamine acetyltransferase;
indoleamine N-acetyltransferase;
N-acetyltransferase;
p-aminosalicylate N-acetyltransferase;
serotonin acetyltransferase;
serotonin N-acetyltransferase |
|---|
| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
|---|
| Sysname |
acetyl-CoA:arylamine N-acetyltransferase |
|---|
| Reaction(IUBMB) |
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine [RN:R02387] |
|---|
| Reaction(KEGG) |
R02387 > R08036;
(other) R07940 R08248 R08250
 |
|---|
| Substrate |
acetyl-CoA [CPD:C00024];
arylamine [CPD:C00292] |
|---|
| Product |
CoA [CPD:C00010];
N-acetylarylamine [CPD:C07565] |
|---|
| Comment |
Wide specificity for aromatic amines, including serotonin; also
catalyses acetyl-transfer between arylamines without CoA. |
|---|
| Pathway |
PATH: ec00232 Caffeine metabolism
PATH: ec00633 Trinitrotoluene degradation
PATH: ec00983 Drug metabolism - other enzymes
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00622 arylamine N-acetyltransferase |
|---|
| Genes |
HSA: 10(NAT2) 9(NAT1)
PTR: 464023(NAT1) 464024(NAT2)
MCC: 704019(NAT1) 704357(NAT2)
MMU: 17960(Nat1) 17961(Nat2) 17962(Nat3)
RNO: 116631(Nat1) 116632(Nat2) 290681(Nat3)
BTA: 512603(NAT1)
ECB: 100049837
MDO: 100027666
OAA: 100077007
GGA: 396283(PNAT10) 396537(NAT) 415809(PNAT3)
TGU: 100222183 100222522 100225095
DRE: 449801 794381
PAU: PA14_63830
REU: Reut_B4044
REH: H16_B1241(nhoA)
RME: Rmet_4744
BVI: Bcep1808_5210
BCN: Bcen_3680
BCH: Bcen2424_4687
PPD: Ppro_1909
MLO: mlr4870
RET: RHE_CH00591(ypch00212) RHE_PE00167(ype00075)
BRA: BRADO6242
BBT: BBta_1363
NAR: Saro_0952
SAL: Sala_2373
BSU: BSU34730(yvcN)
MTU: Rv3566c(nat)
MTC: MT3671(nhoA)
MRA: MRA_3605(nat)
MBO: Mb3596c(nat)
MBB: BCG_3630c(nat)
MPA: MAP0501(nhoA)
MAV: MAV_0595
MSM: MSMEG_0306
MUL: MUL_4131(nat)
MVA: Mvan_0235
MGI: Mflv_0433
MAB: MAB_0013c
MMC: Mmcs_0211
MKM: Mkms_0221
MJL: Mjls_0201
NFA: nfa18420
RHA: RHA1_ro02470(nat)
SEN: SACE_0058
CPH: Cpha266_1973
 |
|---|
| Structures |
PDB: 1GX3 1W5R 1W6F 2BSZ 2IJA 2PFR 2PQT 2VFB 2VFC 3D9W |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:12980945]
CHOU TC, LIPMANN F.
Separation of acetyl transfer enzymes in pigeon liver extract.
J. Biol. Chem. 196 (1952) 89-103.
pigeon |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4748369]
Paul RC, Ratledge C.
Further studies on anthranilate N-acetyltransferase and the
metabolism of N-acetylanthranilic acid in Aerobacter aerogenes.
Biochim. Biophys. Acta. 320 (1973) 9-15.
Klebsiella pneumoniae [GN:kpn] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13084583]
TABOR H, MEHLER AH, STADTMAN ER.
The enzymatic acetylation of amines.
J. Biol. Chem. 204 (1953) 127-38.
pigeon |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:14005907]
WEISSBACH H, REDFIELD BG, AXELROD J.
The exzymic acetylation of serotonin and other naturally occurring
amines.
Biochim. Biophys. Acta. 54 (1961) 190-2.
Rattus norvegicus [GN:rno], Bos taurus [GN:bta], Oryctolagus
cuniculus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.3.1.5
IUBMB Enzyme Nomenclature: 2.3.1.5
ExPASy - ENZYME nomenclature database: 2.3.1.5
UM-BBD (Biocatalysis/Biodegradation Database): 2.3.1.5
BRENDA, the Enzyme Database: 2.3.1.5
CAS: 9027-33-2 |
|---|
