KEGG   ENZYME: 2.3.1.59Help
Entry
EC 2.3.1.59                 Enzyme                                 

Name
gentamicin 2'-N-acetyltransferase;
gentamycin acetyltransferase II;
gentamycin 2'-N-acetyltransferase;
acetyl-CoA:gentamycin-C1a N2'-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:gentamicin-C1a N2'-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + gentamicin C1a = CoA + N2'-acetylgentamicin C1a [RN:R03056]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
gentamicin C1a [CPD:C00908]
Product
CoA [CPD:C00010];
N2'-acetylgentamicin C1a [CPD:C03524]
Comment
The antibiotics gentamicin A, sisomicin, tobramycin, paromomycin, neomycin B, kanamycin B and kanamycin C can also act as acceptors.
History
EC 2.3.1.59 created 1976
Orthology
K17840  
aminoglycoside 2'-N-acetyltransferase I
Genes
PSI: 
PSX: 
PAEU: 
MTU: 
Rv0262c(aac)
MTV: 
MTC: 
MT0275(aac)
MRA: 
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTE: 
MTUR: 
MTL: 
MTO: 
MTD: 
MTN: 
MTJ: 
MTUB: 
MTUE: 
MTX: 
MTUH: 
MTUL: 
MTUT: 
MTUU: 
MTQ: 
MBO: 
Mb0268c(aac)
MBB: 
MBT: 
MBM: 
MBK: 
MBX: 
MBZ: 
MAF: 
MCE: 
MCQ: 
MCV: 
MCX: 
MCZ: 
MMIC: 
MLE: 
ML2551(aac)
MLB: 
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MSG: 
MSB: 
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MSH: 
MSA: 
MUL: 
MVA: 
MGI: 
MSP: 
MAB: 
MABB: 
MMC: 
MKM: 
MJL: 
MMI: 
MRH: 
MCB: 
MLI: 
MKN: 
MKS: 
MKI: 
MNE: 
MYV: 
MYE: 
MGO: 
MFT: 
MHAD: 
MPHL: 
CFN: 
GOQ: 
SMA: 
SAV_2721(aac1)
SGR: 
SGB: 
SBH: 
SHY: 
SHO: 
SVE: 
SDV: 
SFI: 
SALU: 
SALL: 
SGU: 
SVT: 
STRE: 
SCW: 
SLD: 
SXI: 
STRM: 
SAMB: 
SCZ: 
SRW: 
KSK: 
NCA: 
MMAR: 
AOI: 
AJA: 
AMQ: 
ALU: 
PSEA: 
PSEE: 
PSEH: 
PSEQ: 
PECQ: 
SESP: 
KPHY: 
ASE: 
 » show all
Taxonomy
Reference
1  [PMID:4209515]
  Authors
Benveniste R, Davies J.
  Title
Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 70 (1973) 2276-80.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
50864-40-9

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