KEGG   ENZYME: 2.3.1.59Help
Entry
EC 2.3.1.59                 Enzyme                                 
Name
gentamicin 2'-N-acetyltransferase;
gentamycin acetyltransferase II;
gentamycin 2'-N-acetyltransferase;
acetyl-CoA:gentamycin-C1a N2'-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:gentamicin-C1a N2'-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + gentamicin C1a = CoA + N2'-acetylgentamicin C1a [RN:R03056]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
gentamicin C1a [CPD:C00908]
Product
CoA [CPD:C00010];
N2'-acetylgentamicin C1a [CPD:C03524]
Comment
The antibiotics gentamicin A, sisomicin, tobramycin, paromomycin, neomycin B, kanamycin B and kanamycin C can also act as acceptors.
Reference
1  [PMID:4209515]
  Authors
Benveniste R, Davies J.
  Title
Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 70 (1973) 2276-80.
  Organism
Streptomyces kanamyceticus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
50864-40-9
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