KEGG   ENZYME: 2.3.1.6Help
Entry
EC 2.3.1.6                  Enzyme                                 

Name
choline O-acetyltransferase;
choline acetylase;
choline acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:choline O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + choline = CoA + O-acetylcholine [RN:R01023]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
choline [CPD:C00114]
Product
CoA [CPD:C00010];
O-acetylcholine [CPD:C01996]
Comment
Propanoyl-CoA can act, more slowly, in place of acetyl-CoA.
History
EC 2.3.1.6 created 1961
Pathway
Glycerophospholipid metabolism
Orthology
K00623  
choline O-acetyltransferase
Genes
HSA: 
1103(CHAT)
PTR: 
450451(CHAT)
PPS: 
100976056(CHAT)
GGO: 
101129095(CHAT)
PON: 
100444631(CHAT)
NLE: 
100584675(CHAT)
MCC: 
709977(CHAT)
MCF: 
102146741(CHAT)
CJC: 
100391258(CHAT)
MMU: 
12647(Chat)
RNO: 
290567(Chat)
CGE: 
100756785(Chat)
NGI: 
103735013(Chat)
HGL: 
101711939(Chat)
OCU: 
100342226(CHAT)
TUP: 
102490742(CHAT)
CFA: 
486775(CHAT)
AML: 
UMR: 
103668061(CHAT)
FCA: 
751512(CHAT)
PTG: 
102955228(CHAT)
BTA: 
524732(CHAT)
BOM: 
102275818(CHAT)
PHD: 
102330683(CHAT)
CHX: 
102182280(CHAT)
OAS: 
101117817(CHAT)
SSC: 
396896(CHAT)
CFR: 
102512463(CHAT)
BACU: 
103017639(CHAT)
LVE: 
103087947(CHAT)
ECB: 
100062632(CHAT)
MYB: 
MYD: 
102773878(CHAT)
PALE: 
102879671(CHAT)
MDO: 
100019640(CHAT)
OAA: 
100077991(CHAT)
GGA: 
395314(CHAT)
MGP: 
APLA: 
101793965(CHAT)
TGU: 
100231848(CHAT)
FAB: 
101817021(CHAT)
PHI: 
102110760(CHAT)
FPG: 
101920651(CHAT)
FCH: 
102047610(CHAT)
CLV: 
102093477(CHAT)
ASN: 
102377196(CHAT)
AMJ: 
102569949(CHAT)
PSS: 
102449796(CHAT)
CMY: 
102935845(CHAT)
ACS: 
100558883(chat)
PBI: 
XTR: 
100485221(chat)
DRE: 
100170938(chata)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102347699(CHAT)
CMK: 
103181719(chat)
BFO: 
CIN: 
445622(chat)
SPU: 
574696(chat)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
408934(GB15117)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CBR: 
CBG08305(Cbr-cha-1)
BMY: 
LOA: 
HRO: 
LGI: 
SMM: 
ACAN: 
 » show all
Taxonomy
Reference
1  [PMID:13115440]
  Authors
BERMAN R, WILSON IB, NACHMANSOHN D.
  Title
Choline acetylase specificity in relation to biological function.
  Journal
Biochim. Biophys. Acta. 12 (1953) 315-24.
Reference
2  [PMID:13799882]
  Authors
BERRY JF, WHITTAKER VP.
  Title
The acyl-group specificity of choline acetylase.
  Journal
Biochem. J. 73 (1959) 447-58.
Reference
3  [PMID:14299645]
  Authors
FRITZ IB, SCHULTZ SK.
  Title
CARNITINE ACETYLTRANSFERASE. II. INHIBIITON BY CARNITINE ANALOGUES AND BY SULFHYDRYL REAGENTS.
  Journal
J. Biol. Chem. 240 (1965) 2188-92.
Reference
4
  Authors
Schuberth, J.
  Title
Choline acetyltransferase. Purification and effect of salts on the mechanism of the enzyme-catalysed reaction.
  Journal
Biochim. Biophys. Acta 122 (1966) 470-481.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9012-78-6

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