KEGG ENZYME: 2.3.1.74

ENZYME: 2.3.1.74

Entry

EC 2.3.1.74 Enzyme

Name

naringenin-chalcone synthase;
chalcone synthase;
flavanone synthase;
6'-deoxychalcone synthase;
chalcone synthetase;
DOCS;
CHS

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)

Reaction(IUBMB)

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2 [RN:R01613]

Reaction(KEGG)

R01613;
(other) R07987 R07988 R07989

Substrate

malonyl-CoA [CPD:C00083];
4-coumaroyl-CoA [CPD:C00223]

Product

CoA [CPD:C00010];
naringenin chalcone [CPD:C06561];
CO2 [CPD:C00011]

Comment

In the presence of NADH and a reductase, 6'-deoxychalcone is produced.

Pathway

ec00941	Flavonoid biosynthesis
ec01100	Metabolic pathways
ec01110	Biosynthesis of secondary metabolites

Orthology

K00660

chalcone synthase

Genes

ATH:	AT5G13930(TT4)
ALY:	ARALYDRAFT_488219
GMX:	100775264 100809433(chs6) 732575(CHS1)
MTR:	MTR_3g083910 MTR_7g084300
CSV:	101205211 101226380
RCU:	RCOM_1020600
POP:	POPTR_554827(CHS4) POPTR_554828(CHS5) POPTR_554829(CHS6) POPTR_572875(CHS1) POPTR_814871(CHS2) POPTR_814872(CHS3)
VVI:	100232843(CHS) 100258106(CHS3) 100263443(CHS)
OSA:	4350636
DOSA:	Os11t0530600-01(Os11g0530600)
BDI:	100829639
SBI:	SORBI_05g020150(SORBIDRAFT_05g020150) SORBI_05g020160(SORBIDRAFT_05g020160) SORBI_05g020170(SORBIDRAFT_05g020170) SORBI_05g020180(SORBIDRAFT_05g020180) SORBI_05g020190(SORBIDRAFT_05g020190) SORBI_05g020200(SORBIDRAFT_05g020200) SORBI_05g020210(SORBIDRAFT_05g020210) SORBI_05g020220(SORBIDRAFT_05g020220) SORBI_05g020230(SORBIDRAFT_05g020230)
ZMA:	100274415(c2) 100282642
SMO:	SELMODRAFT_230473 SELMODRAFT_270496
PPP:	PHYPADRAFT_100508 PHYPADRAFT_104998 PHYPADRAFT_201011

» show all

Reference

1 [PMID:3355160]

Authors

Ayabe S, Udagawa A, Furuya T.

Title

NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract.

Journal

Arch. Biochem. Biophys. 261 (1988) 458-62.

Organism

Glycyrrhiza echinata

Reference

2 [PMID:7436427]

Authors

Heller W, Hahlbrock K.

Title

Highly purified "flavanone synthase" from parsley catalyzes the formation of naringenin chalcone.

Journal

Arch. Biochem. Biophys. 200 (1980) 617-9.

Organism

Petroselinum hotiense

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.74

IUBMB Enzyme Nomenclature:

2.3.1.74

ExPASy - ENZYME nomenclature database:

2.3.1.74

BRENDA, the Enzyme Database:

2.3.1.74

CAS:

56803-04-4

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (9)   
   KEGG PATHWAY (8)   
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Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (33)   
   KEGG ENZYME (4)   
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Gene (864)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (38)   
   KEGG DGENES (32)   
   KEGG EGENES (793)   
Protein sequence (669)   
   UniProt (389)   
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DNA sequence (762)   
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   GenBank (292)   
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Literature (2)   
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