KEGG   ENZYME: 2.3.1.74Help
Entry
EC 2.3.1.74                 Enzyme                                 

Name
naringenin-chalcone synthase;
chalcone synthase;
flavanone synthase;
6'-deoxychalcone synthase;
chalcone synthetase;
DOCS;
CHS
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Reaction(IUBMB)
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2 [RN:R01613]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083];
4-coumaroyl-CoA [CPD:C00223]
Product
CoA [CPD:C00010];
naringenin chalcone [CPD:C06561];
CO2 [CPD:C00011]
Comment
In the presence of NADH and a reductase, 6'-deoxychalcone is produced.
History
EC 2.3.1.74 created 1984
Pathway
Flavonoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00660  
chalcone synthase
Genes
ATH: 
ALY: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0001s06600g(POPTRDRAFT_750645) POPTR_0001s14310g(POPTRDRAFT_814872) POPTR_0001s14320g(POPTRDRAFT_814871) POPTR_0003s17530g(POPTRDRAFT_554827) POPTR_0003s17540g(POPTRDRAFT_554828) POPTR_0003s17550g(POPTRDRAFT_554829) POPTR_0005s15910g POPTR_0012s13440g POPTR_0014s14200g(POPTRDRAFT_572875)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os07t0214900-00(Os07g0214900) Os11t0530600-01(Os11g0530600)
OBR: 
BDI: 
SBI: 
SORBI_05g020150(SORBIDRAFT_05g020150) SORBI_05g020160(SORBIDRAFT_05g020160) SORBI_05g020170(SORBIDRAFT_05g020170) SORBI_05g020180(SORBIDRAFT_05g020180) SORBI_05g020190(SORBIDRAFT_05g020190) SORBI_05g020200(SORBIDRAFT_05g020200) SORBI_05g020210(SORBIDRAFT_05g020210) SORBI_05g020220(SORBIDRAFT_05g020220) SORBI_05g020230(SORBIDRAFT_05g020230) SORBI_07g004700(SORBIDRAFT_07g004700)
ZMA: 
SITA: 
ATR: 
s00039p00070110(AMTR_s00039p00070110) s00102p00092780(AMTR_s00102p00092780) s00102p00093300(AMTR_s00102p00093300)
SMO: 
PPP: 
 » show all
Taxonomy
Reference
1  [PMID:3355160]
  Authors
Ayabe S, Udagawa A, Furuya T.
  Title
NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract.
  Journal
Arch. Biochem. Biophys. 261 (1988) 458-62.
  Organism
Glycyrrhiza echinata
Reference
2  [PMID:7436427]
  Authors
Heller W, Hahlbrock K.
  Title
Highly purified "flavanone synthase" from parsley catalyzes the formation of naringenin chalcone.
  Journal
Arch. Biochem. Biophys. 200 (1980) 617-9.
  Organism
Petroselinum hotiense
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
56803-04-4

DBGET integrated database retrieval system