KEGG   ENZYME: 2.3.1.76Help
Entry
EC 2.3.1.76                 Enzyme                                 
Name
retinol O-fatty-acyltransferase;
retinol acyltransferase;
retinol fatty-acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:retinol O-acyltransferase
Reaction(IUBMB)
acyl-CoA + retinol = CoA + retinyl ester [RN:R02366]
Reaction(KEGG)
R02366 > R02367;
(other) R08381
Show
Substrate
acyl-CoA [CPD:C00040];
retinol [CPD:C00473]
Product
CoA [CPD:C00010];
retinyl ester [CPD:C02075]
Comment
Acts on palmitoyl-CoA and other long-chain fatty-acyl derivatives of CoA.
Pathway
Retinol metabolism
Orthology
K11155  
diacylglycerol O-acyltransferase 1
K11156  
diacylglycerol O-acyltransferase 2-like protein 4
Genes
HSA: 
158835(AWAT2) 8694(DGAT1)
PTR: 
464460(DGAT1) 473654(AWAT2)
PPS: 
100969745(AWAT2) 100994391(DGAT1)
GGO: 
101142898(DGAT1) 101153985(AWAT2)
PON: 
100444717(AWAT2) 100453587(DGAT1)
MCC: 
696451(AWAT2) 701489(DGAT1)
MMU: 
13350(Dgat1) 245532(Awat2)
RNO: 
302425(Awat2) 84497(Dgat1)
CFA: 
482093(DGAT1) 491936(AWAT2)
AML: 
FCA: 
101086879(AWAT2) 101101615(DGAT1)
BTA: 
282609(DGAT1) 521298(AWAT2)
SSC: 
100151799 397118(DGAT)
ECB: 
100066473
MDO: 
100014456 100018271
SHR: 
100924635 100931966(AWAT2)
ACS: 
100551857
DRE: 
325875(dgat1a)
TRU: 
101079602
OLA: 
101155899
BFO: 
BRAFLDRAFT_280106
CIN: 
100177672
SPU: 
575003
DME: 
Dmel_CG31991(mdy)
DPO: 
Dpse_GA16599
DAN: 
Dana_GF15369
DER: 
Dere_GG22776
DPE: 
Dper_GL18793
DSE: 
Dsec_GM17212
DWI: 
Dwil_GK18239
DYA: 
Dyak_GE12771
DGR: 
Dgri_GH13104
DMO: 
Dmoj_GI14192
DVI: 
Dvir_GJ17509
AGA: 
AgaP_AGAP007843
AAG: 
AaeL_AAEL001204
CQU: 
CpipJ_CPIJ005914
AME: 
552377(mdy)
NVI: 
100116518(NV12873)
TCA: 
664028
PHU: 
Phum_PHUM464830
ISC: 
IscW_ISCW001074
CEL: 
CELE_H19N07.4(mboa-2)
CBR: 
CBG23107
BMY: 
Bm1_52020
TSP: 
Tsp_02502
SMM: 
Smp_127280(dga1)
NVE: 
NEMVE_v1g239390
TAD: 
TRIADDRAFT_35841
AQU: 
100637352
ATH: 
AT2G19450(TAG1)
ALY: 
ARALYDRAFT_480528
GMX: 
547982(DGAT) 548005(DAGAT1)
MTR: 
MTR_2g039940
CSV: 
101213517
RCU: 
RCOM_1047540
POP: 
POPTR_1116472 POPTR_717213
VVI: 
100266364
OSA: 
4338045
DOSA: 
Os05t0196800-00(Os05g0196800) Os06t0563900-01(Os06g0563900)
BDI: 
100827885 100832396
SBI: 
SORBI_09g006110(SORBIDRAFT_09g006110) SORBI_10g022270(SORBIDRAFT_10g022270)
ZMA: 
100383910
SMO: 
SELMODRAFT_138381(TAG1-2)
PPP: 
PHYPADRAFT_189288
VCN: 
VOLCADRAFT_69078
NCR: 
NCU00035
SMP: 
SMAC_00123
PAN: 
PODANSg5375
TTT: 
THITE_2119816
MTM: 
MYCTH_2303878
MGR: 
MGG_05326
FGR: 
FG06688.1
NHE: 
NECHADRAFT_100228
VAL: 
VDBG_08786
SSL: 
SS1G_13567
BFU: 
BC1G_10420
ANI: 
AN6159.2
NFI: 
NFIA_084010
AFM: 
AFUA_2G08380
AOR: 
AOR_1_1456054(AO090011000863)
ANG: 
ANI_1_1688104(An12g03600)
AFV: 
AFLA_046610
ACT: 
ACLA_080210
PCS: 
Pc13g04400
CIM: 
CIMG_00860
CPW: 
CPC735_054550
PBL: 
PAAG_07527
URE: 
UREG_00818
ABE: 
ARB_04951
AJE: 
HCAG_07348
PNO: 
SNOG_13711
PTE: 
PTT_18543
ZTR: 
MYCGRDRAFT_108832
TML: 
GSTUM_00010199001
EIN: 
Eint_100250
EHE: 
EHEL_100300
NCE: 
NCER_100059
MBR: 
MONBRDRAFT_20830
NGR: 
NAEGRDRAFT_80131
DDI: 
DDB_G0271342(dgat1)
DPP: 
DICPUDRAFT_154444
PTI: 
PHATRDRAFT_9794
TPS: 
THAPSDRAFT_261279(DGT)
 » show all
Taxonomy
Reference
1  [PMID:6826734]
  Authors
Helgerud P, Petersen LB, Norum KR.
  Title
Retinol esterification by microsomes from the mucosa of human small intestine. Evidence for acyl-Coenzyme A retinol acyltransferase activity.
  Journal
J. Clin. Invest. 71 (1983) 747-53.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:7061433]
  Authors
Ross AC.
  Title
Retinol esterification by rat liver microsomes. Evidence for a fatty acyl coenzyme A: retinol acyltransferase.
  Journal
J. Biol. Chem. 257 (1982) 2453-9.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
81295-48-9
DBGET integrated database retrieval system