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Entry
EC 2.3.1.80                 Enzyme                                 

Name
cysteine-S-conjugate N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:S-substituted L-cysteine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an L-cysteine-S-conjugate = CoA + an N-acetyl-L-cysteine-S-conjugate [RN:R04950]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
L-cysteine-S-conjugate [CPD:C02882]
Product
CoA [CPD:C00010];
N-acetyl-L-cysteine-S-conjugate
Comment
S-Benzyl-L-cysteine and, in decreasing order of activity, S-butyl-L-cysteine, S-propyl-L-cysteine, O-benzyl-L-serine and S-ethyl-L-cysteine, can act as acceptors.
History
EC 2.3.1.80 created 1984
Pathway
Glutathione metabolism
Orthology
K20838  
N-acetyltransferase 8
Genes
HSA: 
51471(NAT8B) 9027(NAT8)
PTR: 
470406(NAT8) 739241(NAT8B)
PPS: 
100967484(NAT8) 100971190(NAT8B)
GGO: 
101133830(NAT8B)
PON: 
100173062(NAT8) 100435458(NAT8B)
NLE: 
100606331(NAT8) 100606676(NAT8B)
MCC: 
706820(NAT8)
MCF: 
102119614(NAT8)
CSAB: 
RRO: 
CJC: 
SBQ: 
101032039(NAT8)
MMU: 
66116(Nat8f1) 68396(Nat8)
RNO: 
CGE: 
NGI: 
103749950(Nat8b)
HGL: 
OCU: 
TUP: 
102482811(NAT8)
CFA: 
100856478(NAT8B)
AML: 
UMR: 
FCA: 
101098621(NAT8)
PTG: 
102957307(NAT8B)
BTA: 
101902604(NAT8)
BOM: 
102278525(NAT8)
PHD: 
102317853(NAT8B)
CHX: 
102181787(NAT8)
OAS: 
101104899(NAT8B)
SSC: 
100516363(NAT8)
CFR: 
102507921(NAT8B)
BACU: 
103001786(NAT8) 103011589(NAT8B)
ECB: 
MYB: 
MYD: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
CJO: 
PHI: 
FPG: 
FCH: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
GJA: 
XLA: 
XTR: 
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
SKO: 
OBI: 
ADF: 
LBC: 
MRR: 
CCI: 
TET: 
PSOJ: 
 » show all
Taxonomy
Reference
1  [PMID:6892478]
  Authors
Duffel MW, Jakoby WB.
  Title
Cysteine S-conjugate N-acetyltransferase from rat kidney microsomes.
  Journal
Mol. Pharmacol. 21 (1982) 444-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
81725-80-6

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