KEGG   ENZYME: 2.3.1.85Help
Entry
EC 2.3.1.85                 Enzyme                                 

Name
fatty-acid synthase;
FASN (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
Reaction(IUBMB)
acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+ [RN:R05188]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
long-chain fatty acid [CPD:C00638];
CoA [CPD:C00010];
CO2 [CPD:C00011];
NADP+ [CPD:C00006]
Comment
The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 3-oxoacyl-[acyl-carrier-protein] synthase, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase. cf. EC 2.3.1.86, fatty-acyl-CoA synthase.
History
EC 2.3.1.85 created 1984
Pathway
Fatty acid biosynthesis
Metabolic pathways
Orthology
K00665  
fatty acid synthase, animal type
Genes
HSA: 
2194(FASN)
PTR: 
454986(FASN)
PPS: 
100985873(FASN)
GGO: 
101151060(FASN)
PON: 
100456558(FASN)
MCC: 
715708(FASN)
MCF: 
102119674(FASN)
MMU: 
14104(Fasn)
RNO: 
50671(Fasn)
CGE: 
100689207(Fasn)
HGL: 
101698314(Fasn)
TUP: 
102481635(FASN)
CFA: 
483378(FASN)
AML: 
FCA: 
100270775(FASN)
BTA: 
281152(FASN)
BOM: 
102278267(FASN)
PHD: 
102336161(FASN)
CHX: 
100861286(FASN)
SSC: 
397561(FASN)
CFR: 
102509439(FASN)
ECB: 
100057311(FASN)
MYB: 
102251003(FASN)
MDO: 
100025176(FASN)
SHR: 
100924144(FASN)
GGA: 
396061(FASN)
MGP: 
TGU: 
100226957(FASN)
FAB: 
101820764(FASN)
PHI: 
102102393(FASN)
APLA: 
101796973(FASN)
FPG: 
101924649(FASN)
FCH: 
102046127(FASN)
CLV: 
102086015(FASN)
ASN: 
102384493(FASN)
PSS: 
102458578(FASN)
ACS: 
XTR: 
100487052(fasn)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102352909(FASN)
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
411959(GB16883) 412815(GB12198)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_F32H2.5(fasn-1)
CBR: 
CBG12408(Cbr-fasn-1)
BMY: 
LOA: 
TSP: 
TAD: 
CSL: 
 » show all
Taxonomy
Reference
1  [PMID:457689]
  Authors
Stoops JK, Ross P, Arslanian MJ, Aune KC, Wakil SJ, Oliver RM.
  Title
Physicochemical studies of the rat liver and adipose fatty acid synthetases.
  Journal
J. Biol. Chem. 254 (1979) 7418-26.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:6137188]
  Authors
Wakil SJ, Stoops JK, Joshi VC.
  Title
Fatty acid synthesis and its regulation.
  Journal
Annu. Rev. Biochem. 52 (1983) 537-79.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9045-77-6

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