KEGG   ENZYME: 2.3.1.86Help
Entry
EC 2.3.1.86                 Enzyme                                 
Name
fatty-acyl-CoA synthase;
yeast fatty acid synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)
Reaction(IUBMB)
acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = long-chain-acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+ [RN:R05190]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
long-chain-acyl-CoA;
CoA [CPD:C00010];
CO2 [CPD:C00011];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Comment
The yeast enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 3-oxoacyl-[acyl-carrier-protein] synthase, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 1.1.1.279, (R)-3-hydroxyacid ester dehydrogenase, EC 4.2.1.59 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase and EC 1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH).
Pathway
Fatty acid biosynthesis
Metabolic pathways
Orthology
K00667  
fatty acid synthase subunit alpha, fungi type
K00668  
fatty acid synthase subunit beta, fungi type
Genes
SCE: 
YKL182W(FAS1) YPL231W(FAS2)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0G01260(NCAS0G01260) NCAS_0J01680(NCAS0J01680)
NDI: 
NDAI_0F01390(NDAI0F01390) NDAI_0J02670(NDAI0J02670)
TPF: 
TPHA_0B02040(TPHA0B02040) TPHA_0H01860(TPHA0H01860)
TBL: 
TBLA_0C02010(TBLA0C02010) TBLA_0I03120(TBLA0I03120)
TDL: 
TDEL_0A06700(TDEL0A06700) TDEL_0E00900(TDEL0E00900)
KAF: 
KAFR_0A05730(KAFR0A05730) KAFR_0F01200(KAFR0F01200)
DHA: 
DEHA2B08140g DEHA2B10032g
PIC: 
PICST_80966(FAS2) PICST_85125(FAS1)
PGU: 
PGUG_02105 PGUG_02173
LEL: 
LELG_02891 LELG_02892 LELG_03854
CAL: 
CaO19.13370 CaO19.5949 CaO19.8594(FAS1) CaO19.979(FAS1)
CTP: 
CTRG_02501 CTRG_05241
CDU: 
CD36_50220(FAS1) CD36_84800
COT: 
CORT_0C01740 CORT_0E04830
YLI: 
YALI0B15059g YALI0B19382g
CLU: 
CLUG_03422 CLUG_04160
NCR: 
NCU07307 NCU07308
SMP: 
SMAC_00840 SMAC_00841
PAN: 
PODANSg3685 PODANSg3686
TTT: 
THITE_2122453 THITE_2122457
MTM: 
MYCTH_2310228 MYCTH_2310232
MGR: 
MGG_04118 MGG_12154
FGR: 
FG00036.1 FG05321.1 FG05322.1
NHE: 
NECHADRAFT_64009 NECHADRAFT_72277
VAL: 
VDBG_01018 VDBG_01020
SSL: 
SS1G_13073 SS1G_13074
BFU: 
BC1G_14051 BC1G_14055
ANI: 
AN7873.2 AN7880.2 AN9407.2 AN9408.2
NFI: 
NFIA_006480 NFIA_006490
AFM: 
AFUA_3G04210 AFUA_3G04220
AOR: 
AOR_1_156104(AO090124000083) AOR_1_158104(AO090124000084) AOR_1_276024(AO090010000156)
ANG: 
ANI_1_6014(An01g00060)
AFV: 
AFLA_089160 AFLA_089170 AFLA_117290
ACT: 
ACLA_060580 ACLA_060590 ACLA_093750 ACLA_093760
PCS: 
Pc14g00740 Pc14g00750
CIM: 
CIMG_08477 CIMG_08479
CPW: 
CPC735_061450 CPC735_061460
PBL: 
PAAG_01524 PAAG_01525
URE: 
UREG_02553 UREG_02554 UREG_04458 UREG_04459
ABE: 
ARB_02752 ARB_02757 ARB_06046 ARB_06048
TVE: 
TRV_06188 TRV_06193 TRV_06922 TRV_06923
AJE: 
HCAG_07636 HCAG_07637
PNO: 
SNOG_02166 SNOG_02167 SNOG_09089 SNOG_09091
PTE: 
PTT_02058 PTT_02059
ZTR: 
MYCGRDRAFT_108403(FAS1) MYCGRDRAFT_69244
TML: 
GSTUM_00002095001
SPO: 
SPAC4A8.11c(fas2) SPAC926.09c(fas1)
CNE: 
CNE04360 CNE04370
CNB: 
CNBE4360 CNBE4370
CGI: 
CGB_E5650C CGB_E5660W
LBC: 
LACBIDRAFT_296983(FAS-2)
MPR: 
MPER_07767 MPER_12305
CCI: 
CC1G_07064
SCM: 
SCHCODRAFT_82184
UMA: 
UM02971.1
PGR: 
PGTG_06184
PIF: 
PITG_10922
 » show all
Taxonomy
Reference
1  [PMID:4590449]
  Authors
Schweizer E, Kniep B, Castorph H, Holzner U.
  Title
Pantetheine-free mutants of the yeast fatty-acid-synthetase complex.
  Journal
Eur. J. Biochem. 39 (1973) 353-62.
  Organism
Saccharomyces cerevisiae [GN:sce]
Reference
2  [PMID:6137188]
  Authors
Wakil SJ, Stoops JK, Joshi VC.
  Title
Fatty acid synthesis and its regulation.
  Journal
Annu. Rev. Biochem. 52 (1983) 537-79.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
94219-29-1
DBGET integrated database retrieval system