KEGG   ENZYME: 2.3.1.87Help
Entry
EC 2.3.1.87                 Enzyme                                 

Name
aralkylamine N-acetyltransferase;
serotonin acetyltransferase;
serotonin acetylase;
arylalkylamine N-acetyltransferase;
serotonin N-acetyltransferase;
AANAT;
melatonin rhythm enzyme
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:2-arylethylamine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine [RN:R03760]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
2-arylethylamine [CPD:C15534]
Product
CoA [CPD:C00010];
N-acetyl-2-arylethylamine [CPD:C15535]
Comment
Narrow specificity towards 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4, acetylserotonin O-methyltransferase). Differs from EC 2.3.1.5 arylamine N-acetyltransferase.
History
EC 2.3.1.87 created 1986, modified 2005
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K00669  arylalkylamine N-acetyltransferase
K22450  aralkylamine N-acetyltransferase
Genes
HSA: 15(AANAT)
PTR: 503504(AANAT)
PPS: 100977321(AANAT)
GGO: 101129527(AANAT)
PON: 100433977(AANAT)
NLE: 100600128(AANAT)
MCC: 706924(AANAT)
MCF: 102127968(AANAT)
CSAB: 103242991(AANAT)
RRO: 104681272(AANAT)
RBB: 108537333(AANAT)
CJC: 100406947(AANAT)
SBQ: 101027986(AANAT)
MMU: 11298(Aanat)
RNO: 25120(Aanat)
CGE: 100755392(Aanat)
NGI: 103732690(Aanat)
HGL: 101713893(Aanat)
CCAN: 109685598(Aanat)
OCU: 100357535(AANAT)
TUP: 102470373(AANAT)
CFA: 483331(AANAT)
AML: 100482847(AANAT)
UMR: 103665763(AANAT)
ORO: 101375231(AANAT)
FCA: 101098178(AANAT)
PTG: 102953543(AANAT)
BTA: 281583(AANAT)
PHD: 102337675
CHX: 100860947(AANAT) 102190991(AANAT)
OAS: 105601853 443531(AANAT)
SSC: 100518330
CFR: 102522698(AANAT)
CDK: 105092185(AANAT)
BACU: 103011665(AANAT)
LVE: 103071739(AANAT)
OOR: 101286550(AANAT)
ECB: 100058770(AANAT)
EPZ: 103565530(AANAT)
EAI: 106830333(AANAT)
MYB: 102257691(AANAT)
HAI: 109383638(AANAT)
RSS: 109454667(AANAT)
PALE: 102898841(AANAT)
LAV: 100667906(AANAT)
MDO: 100026619(AANAT)
SHR: 100924836(AANAT)
OAA: 100076568(AANAT)
GGA: 396066(AANAT)
MGP: 100549848(AANAT)
CJO: 107322266(AANAT)
APLA: 101798734(AANAT)
ACYG: 106034630(AANAT)
TGU: 100228432(AANAT)
GFR: 102044523(AANAT)
FAB: 101817679(AANAT)
PHI: 102107121(AANAT)
PMAJ: 107212354(AANAT)
CCW: 104694394(AANAT)
FPG: 101917150(AANAT)
FCH: 102045840(AANAT)
CLV: 102097087(AANAT)
EGZ: 104125379(AANAT)
AAM: 106485386(AANAT)
ASN: 102385650(AANAT)
AMJ: 102558329(AANAT)
PSS: 102454343(AANAT)
CMY: 102939980(AANAT)
CPIC: 101949766(AANAT)
ACS: 100560631(aanat)
PVT: 110085911(AANAT)
PBI: 103059427(AANAT)
GJA: 107121146(AANAT)
XLA: 100335045(aanat-a) 100335046(aanat)
XTR: 100497589(aanat)
NPR: 108796857(AANAT)
DRE: 30685(aanat2) 393677(aanat1)
IPU: 108257103 108273103(aanat)
AMEX: 103029239 103031094(aanat)
OLA: 100049467(aanat) 100049488(aanat2) 100049507(aanat1b)
SFM: 108935849 108939955(aanat)
LCM: 102349438(AANAT)
CMK: 103188407(aanat)
DME: Dmel_CG3318(Dat)
ATH: AT1G26220 AT1G32070(NSI)
LJA: Lj1g3v2536100.1(Lj1g3v2536100.1)
DOSA: Os05t0481000-01(Os05g0481000) Os08t0102000-01(Os08g0102000)
ATS: 109752019(LOC109752019) 109764125(LOC109764125)
AOF: 109822178
 » show all
Taxonomy
Reference
1  [PMID:6469990]
  Authors
Voisin P, Namboodiri MA, Klein DC.
  Title
Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland.
  Journal
J. Biol. Chem. 259 (1984) 10913-8.
Reference
2  [PMID:10722724]
  Authors
Ferry G, Loynel A, Kucharczyk N, Bertin S, Rodriguez M, Delagrange P, Galizzi JP, Jacoby E, Volland JP, Lesieur D, Renard P, Canet E, Fauchere JL, Boutin JA.
  Title
Substrate specificity and inhibition studies of human serotonin N-acetyltransferase.
  Journal
J. Biol. Chem. 275 (2000) 8794-805.
Reference
3
  Authors
Khalil, E.M. and Cole, P.A.
  Title
A potent inhibitor of the melatonin rhythm enzyme.
  Journal
J. Am. Chem. Soc. 120 (1998) 6195-6196.
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.87
IUBMB Enzyme Nomenclature: 2.3.1.87
ExPASy - ENZYME nomenclature database: 2.3.1.87
BRENDA, the Enzyme Database: 2.3.1.87
CAS: 92941-56-5

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