KEGG   ENZYME: 2.3.2.22Help
Entry
EC 2.3.2.22                 Enzyme                                 

Name
cyclo(L-leucyl-L-leucyl) synthase;
YvmC;
cLL synthase;
cyclodileucine synthase
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy
Sysname
L-leucyl-tRNALeu:L-leucyl-tRNALeu leucyltransferase (cyclizing)
Reaction(IUBMB)
2 L-leucyl-tRNALeu = 2 tRNALeu + cyclo(L-leucyl-L-leucyl) [RN:R10336]
Reaction(KEGG)
Substrate
L-leucyl-tRNA(Leu) [CPD:C02047]
Product
tRNA(Leu) [CPD:C01645];
cyclo(L-leucyl-L-leucyl) [CPD:C20514]
Comment
The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-leucine residue [2]. The proteins from bacteria of the genus Bacillus also form small amounts of cyclo(L-phenylalanyl-L-leucyl) and cyclo(L-leucyl-L-methionyl) [1].
History
EC 2.3.2.22 created 2013
Orthology
K17485  
cyclo(L-leucyl-L-leucyl) synthase
Genes
BSU: 
BSU35070(yvmC)
BSL: 
BSH: 
BSUT: 
BSUL: 
BSUS: 
BSS: 
BST: 
BSQ: 
BSP: 
BLI: 
BL00817(yvmC)
BLD: 
BLi03566(yvmC)
BLH: 
BBY: 
BACY: 
BACL: 
BALM: 
SEPS: 
SHA: 
SSD: 
SDT: 
 » show all
Taxonomy
Reference
1  [PMID:19430487]
  Authors
Gondry M, Sauguet L, Belin P, Thai R, Amouroux R, Tellier C, Tuphile K, Jacquet M, Braud S, Courcon M, Masson C, Dubois S, Lautru S, Lecoq A, Hashimoto S, Genet R, Pernodet JL
  Title
Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes.
  Journal
Nat. Chem. Biol. 5 (2009) 414-20.
Reference
2  [PMID:21325056]
  Authors
Bonnefond L, Arai T, Sakaguchi Y, Suzuki T, Ishitani R, Nureki O
  Title
Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 108 (2011) 3912-7.
  Sequence
[bli:BL00817]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system