| Entry |
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| Name |
glutaminyl-peptide cyclotransferase;
glutaminyl-tRNA cyclotransferase;
glutaminyl cyclase;
glutaminyl-transfer ribonucleate cyclotransferase
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| Class |
Transferases;
Acyltransferases;
Aminoacyltransferases
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| Sysname |
L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)
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| Reaction(IUBMB) |
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3 [RN: R04058]
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| Reaction(KEGG) |
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| Substrate |
L-glutaminyl-peptide [CPD: C02986]
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| Product |
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| Comment |
Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. The enzyme from papaya also acts on glutaminyl-tRNA.
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| Orthology |
| glutaminyl-peptide cyclotransferase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | API: | | ISC: | | CEL: | | CBR: | | BMY: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | CGR: | | AOR: | | MBR: | | NGR: | | DDI: | | TBR: | | YPN: | | XCC: | | XCB: | | XCV: | | XAC: | | XOO: | | XOM: | | MMR: | | SPZ: | | SPH: | | SPI: | | SPJ: | | SPK: | | SPF: | | SPA: | | SPB: | | CGB: | | CGT: | | SEN: | | SUS: | | GFO: | | DGE: | |
» show all
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| Reference |
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| Authors |
Busby WH Jr, Quackenbush GE, Humm J, Youngblood WW, Kizer JS. |
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| Title |
An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes. |
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| Journal |
J. Biol. Chem. 262 (1987) 8532-6. |
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| Organism |
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| Reference |
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| Authors |
Fischer WH, Spiess J. |
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| Title |
Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides. |
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| Journal |
Proc. Natl. Acad. Sci. U. S. A. 84 (1987) 3628-32. |
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| Organism |
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| Reference |
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| Authors |
Messer M, Ottesen M. |
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| Title |
Isolation and properties of glutamine cyclotransferase of dried papaya latex. |
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| Journal |
C. R. Trav. Lab. Carlsberg. 35 (1965) 1-24. |
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| Organism |
Carica papaya |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37257-21-9 |
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