KEGG   ENZYME: 2.3.3.16Help
Entry
EC 2.3.3.16                 Enzyme                                 

Name
citrate synthase (unknown stereospecificity);
citrate condensing enzyme;
CoA-acetylating citrate oxaloacetate-lyase;
citrate synthetase;
citric synthase;
citric-condensing enzyme;
citrogenase;
condensing enzyme (ambiguous);
oxaloacetate transacetase;
oxalacetic transacetase
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
BRITE hierarchy
Sysname
acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
Reaction(IUBMB)
acetyl-CoA + H2O + oxaloacetate = citrate + CoA [RN:R00351]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
H2O [CPD:C00001];
oxaloacetate [CPD:C00036]
Product
citrate [CPD:C00158];
CoA [CPD:C00010]
Comment
This entry has been included to accommodate those citrate synthases for which the stereospecificity with respect to C2 of oxaloacetate has not been established [cf. EC 2.3.3.1, citrate (Si)-synthase and EC 2.3.3.3, citrate (Re)-synthase].
History
EC 2.3.3.16 created 2014
Reference
1  [PMID:3130075]
  Authors
Lohlein-Werhahn G, Goepfert P, Eggerer H
  Title
Purification and properties of an archaebacterial enzyme: citrate synthase from Sulfolobus solfataricus.
  Journal
Biol. Chem. Hoppe. Seyler. 369 (1988) 109-13.
Reference
2  [PMID:8997706]
  Authors
Sievers M, Stockli M, Teuber M
  Title
Purification and properties of citrate synthase from Acetobacter europaeus.
  Journal
FEMS. Microbiol. Lett. 146 (1997) 53-8.
Reference
3  [PMID:9113733]
  Authors
Belova LL, Sokolov AP, Morgunov IG, Trotsenko YuA
  Title
Purification and characterization of citrate synthase from Methylobacterium extorquens--a methylotrophic producer of polyhydroxybutyrate.
  Journal
Biochemistry. (Mosc). 62 (1997) 71-6.
Reference
4  [PMID:9387145]
  Authors
Lee S, Park C, Yim J
  Title
Characterization of citrate synthase purified from Drosophila melanogaster.
  Journal
Mol. Cells. 7 (1997) 599-604.
Reference
5  [PMID:12741811]
  Authors
Maurus R, Nguyen NT, Stokell DJ, Ayed A, Hultin PG, Duckworth HW, Brayer GD
  Title
Insights into the evolution of allosteric properties. The NADH binding site of hexameric type II citrate synthases.
  Journal
Biochemistry. 42 (2003) 5555-65.
  Sequence
[eco:b0720]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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