KEGG   ENZYME: 2.3.3.3Help
Entry
EC 2.3.3.3                  Enzyme                                 

Name
citrate (Re)-synthase;
(R)-citrate synthase;
Re-citrate-synthase;
citrate oxaloacetate-lyase [(pro-3R)-CH2COO-->acetyl-CoA]
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
BRITE hierarchy
Sysname
acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]
Reaction(IUBMB)
acetyl-CoA + H2O + oxaloacetate = citrate + CoA [RN:R00351]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
H2O [CPD:C00001];
oxaloacetate [CPD:C00036]
Product
citrate [CPD:C00158];
CoA [CPD:C00010]
Comment
This enzyme is inactivated by oxygen and is found in some anaerobes. Its stereospecificity is opposite to that of EC 2.3.3.1, citrate (Si)-synthase.
History
EC 2.3.3.3 created 1972 as EC 4.1.3.28, transferred 2002 to EC 2.3.3.3
Reference
1  [PMID:5808294]
  Authors
Dittbrenner S, Chowdhury AA, Gottschalk G.
  Title
The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate.
  Journal
Biochem. Biophys. Res. Commun. 36 (1969) 802-8.
  Organism
Clostridium kluyveri, Clostridium acidi-urici
Reference
2  [PMID:4974734]
  Authors
Gottschalk G.
  Title
Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici.
  Journal
Eur. J. Biochem. 7 (1969) 301-6.
  Organism
Clostridium acidi-urici
Reference
3  [PMID:5958189]
  Authors
Gottschalk G, Barker HA.
  Title
Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase.
  Journal
Biochemistry. 5 (1966) 1125-33.
  Organism
Clostridium kluyveri
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9077-70-7

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