KEGG   ENZYME: 2.4.1.109Help
Entry
EC 2.4.1.109                Enzyme                                 

Name
dolichyl-phosphate-mannose---protein mannosyltransferase;
dolichol phosphomannose-protein mannosyltransferase;
protein O-D-mannosyltransferase;
dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase;
dolichyl-phosphate-mannose-protein mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dolichyl-D-mannosyl-phosphate:protein O-D-mannosyltransferase
Reaction(IUBMB)
dolichyl D-mannosyl phosphate + protein = dolichyl phosphate + O-D-mannosylprotein [RN:R04072 R07620]
Reaction(KEGG)
Substrate
dolichyl D-mannosyl phosphate [CPD:C03862];
protein [CPD:C00017]
Product
dolichyl phosphate [CPD:C00110];
O-D-mannosylprotein [CPD:C02863]
Comment
The enzyme transfers mannosyl residues to the hydroxy group of serine or threonine residues, producing cell-wall mannoproteins. It acts only on long-chain alpha-dihydropolyprenyl derivatives, larger than C35.
History
EC 2.4.1.109 created 1983, modified 2014
Pathway
Other types of O-glycan biosynthesis
Orthology
K00728  
dolichyl-phosphate-mannose-protein mannosyltransferase
Genes
HSA: 
10585(POMT1) 29954(POMT2)
PTR: 
453067(POMT2) 473076(POMT1)
PPS: 
100969666(POMT1) 100991424(POMT2)
GGO: 
101129927(POMT1) 101140993(POMT2)
PON: 
100437813(POMT2)
NLE: 
100583229(POMT1) 100597409(POMT2)
MCC: 
705604(POMT2) 722387(POMT1)
MCF: 
102136913(POMT2) 102140167(POMT1)
CJC: 
100400916(POMT2) 100401935(POMT1)
MMU: 
217734(Pomt2) 99011(Pomt1)
RNO: 
688673(Pomt2) 84430(Pomt1)
CGE: 
100755033(Pomt1) 100764752(Pomt2)
NGI: 
103727607(Pomt1) 103739582(Pomt2)
HGL: 
101706534(Pomt2) 101719016(Pomt1)
OCU: 
100357260(POMT2) 100357781(POMT1)
TUP: 
102470633(POMT2) 102491271(POMT1)
CFA: 
480400(POMT2) 608039(POMT1)
AML: 
UMR: 
103670255(POMT1) 103674072(POMT2)
FCA: 
101088629(POMT1) 101101141(POMT2)
PTG: 
102962030(POMT1) 102968434(POMT2)
BTA: 
537054(POMT2) 617609(POMT1)
BOM: 
102279725(POMT2) 102286979(POMT1)
PHD: 
CHX: 
102169594(POMT2) 102176050(POMT1)
OAS: 
101110065(POMT2) 101121672(POMT1)
SSC: 
100155173(POMT2) 100525803(POMT1)
CFR: 
102514392(POMT2) 102521239(POMT1)
BACU: 
103008355(POMT2) 103018656(POMT1)
LVE: 
103069264(POMT1) 103089885(POMT2)
ECB: 
100059121(POMT2) 100069575(POMT1)
MYB: 
102250898(POMT1) 102261340(POMT2)
MYD: 
102756063(POMT1) 102763673(POMT2)
PALE: 
102881991(POMT1) 102896335(POMT2)
MDO: 
100016377(POMT1) 100022191(POMT2)
SHR: 
100927549(POMT2) 100931363(POMT1)
OAA: 
100075192(POMT1) 100077316(POMT2)
GGA: 
417175(POMT1) 423373(POMT2)
MGP: 
APLA: 
101796417(POMT1) 101803424(POMT2)
TGU: 
100221491(POMT1) 100227792(POMT2)
FAB: 
101818924(POMT1) 101820143(POMT2)
PHI: 
102099802(POMT2) 102101108(POMT1)
FPG: 
101914245(POMT2) 101920099(POMT1)
FCH: 
102051602(POMT1) 102052371(POMT2)
CLV: 
102089813(POMT2) 102092682(POMT1)
ASN: 
102373766(POMT2) 102375614(POMT1)
AMJ: 
102567821(POMT1) 102569546(POMT2)
PSS: 
102459251(POMT1) 102463352(POMT2)
CMY: 
102942390(POMT1) 102945073(POMT2)
ACS: 
100566915(pomt2) 103282313(pomt1)
PBI: 
103056094(POMT2) 103063082(POMT1)
XTR: 
100490100(pomt2) 448433(pomt1)
DRE: 
563878(pomt2) 569769(pomt1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102356244(POMT2) 102357324(POMT1)
CMK: 
103183034(pomt1) 103189968(pomt2)
BFO: 
CIN: 
SPU: 
580971(pomt2) 588991(pomt1)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
551420 551578(GB11823)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
LGI: 
NVE: 
HMG: 
TAD: 
AQU: 
CME: 
GSL: 
CCP: 
SCE: 
YAL023C(PMT2) YDL093W(PMT5) YDL095W(PMT1) YDR307W(PMT7) YGR199W(PMT6) YJR143C(PMT4) YOR321W(PMT3)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A07260(NCAS0A07260) NCAS_0B05850(NCAS0B05850) NCAS_0B05860(NCAS0B05860) NCAS_0F01660(NCAS0F01660) NCAS_0F02750(NCAS0F02750) NCAS_0I00420(NCAS0I00420) NCAS_0J02260(NCAS0J02260)
NDI: 
NDAI_0A08600(NDAI0A08600) NDAI_0B03160(NDAI0B03160) NDAI_0B03170(NDAI0B03170) NDAI_0C04210(NDAI0C04210) NDAI_0D02240(NDAI0D02240) NDAI_0H02540(NDAI0H02540) NDAI_0J02980(NDAI0J02980)
TPF: 
TPHA_0A04800(TPHA0A04800) TPHA_0B00290(TPHA0B00290) TPHA_0C03750(TPHA0C03750) TPHA_0E01230(TPHA0E01230) TPHA_0G01950(TPHA0G01950) TPHA_0H02700(TPHA0H02700) TPHA_0L00440(TPHA0L00440)
TBL: 
TBLA_0A02990(TBLA0A02990) TBLA_0A04640(TBLA0A04640) TBLA_0A10670(TBLA0A10670) TBLA_0B05710(TBLA0B05710) TBLA_0B07650(TBLA0B07650) TBLA_0B09470(TBLA0B09470) TBLA_0E02320(TBLA0E02320)
TDL: 
TDEL_0D00380(TDEL0D00380) TDEL_0E02980(TDEL0E02980) TDEL_0E04890(TDEL0E04890) TDEL_0G02920(TDEL0G02920) TDEL_0H03750(TDEL0H03750)
KAF: 
KAFR_0B00800(KAFR0B00800) KAFR_0D01190(KAFR0D01190) KAFR_0E04460(KAFR0E04460) KAFR_0G01180(KAFR0G01180) KAFR_0K00650(KAFR0K00650) KAFR_0K02390(KAFR0K02390) KAFR_0K02400(KAFR0K02400)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CaO19.11283(PMT6) CaO19.11590(PMT4) CaO19.12638(PMT1) CaO19.14104(PMT2) CaO19.3802(PMT6) CaO19.4109(PMT4) CaO19.5171(PMT1) CaO19.6812(PMT2) CaO19_5171(CaJ7_0330)
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT105770(NEUTE1DRAFT_105770) NEUTE1DRAFT122991(NEUTE1DRAFT_122991) NEUTE1DRAFT70939(NEUTE1DRAFT_70939)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_180084(AO090020000105) AOR_1_1802194(AO090012001021) AOR_1_578144(AO090023000336)
ANG: 
ANI_1_1134144(An16g08490) ANI_1_1278094(An11g09890) ANI_1_1328064(An07g10350)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT118848(AGABI1DRAFT_118848) AGABI1DRAFT119690(AGABI1DRAFT_119690) AGABI1DRAFT35577(AGABI1DRAFT_35577)
ABV: 
AGABI2DRAFT205019(AGABI2DRAFT_205019) AGABI2DRAFT205915(AGABI2DRAFT_205915) AGABI2DRAFT67868(AGABI2DRAFT_67868)
CPUT: 
SLA: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
WSE: 
WIC: 
ECU: 
EIN: 
EHE: 
ERO: 
NCE: 
MBR: 
EHX: 
TVA: 
 » show all
Taxonomy
Reference
1  [PMID:6989607]
  Authors
Babczinski P, Haselbeck A, Tanner W.
  Title
Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme.
  Journal
Eur. J. Biochem. 105 (1980) 509-15.
Reference
2  [PMID:6445267]
  Authors
Palamarczyk G, Lehle L, Mankowski T, Chojnacki T, Tanner W.
  Title
Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives.
  Journal
Eur. J. Biochem. 105 (1980) 517-23.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
74315-99-4

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