| Entry |
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| Name |
glycogen(starch) synthase;
UDP-glucose---glycogen glucosyltransferase;
glycogen (starch) synthetase;
UDP-glucose-glycogen glucosyltransferase;
UDP-glycogen synthase;
UDPG-glycogen synthetase;
UDPG-glycogen transglucosylase;
uridine diphosphoglucose-glycogen glucosyltransferase
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| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
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| Sysname |
UDP-glucose:glycogen 4-alpha-D-glucosyltransferase
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| Reaction(IUBMB) |
UDP-glucose + [(1->4)-alpha-D-glucosyl]n = UDP + [(1->4)-alpha-D-glucosyl]n+1 [RN: R00292 R06051]
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| Reaction(KEGG) |
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| Substrate |
UDP-glucose [CPD: C00029];
[(1->4)-alpha-D-glucosyl]n
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| Product |
UDP [CPD: C00015];
[(1->4)-alpha-D-glucosyl]n+1
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| Comment |
The accepted name varies according to the source of the enzyme and the nature of its synthetic product (cf. EC 2.4.1.1, phosphorylase). Glycogen synthase from animal tissues is a complex of a catalytic subunit and the protein glycogenin. The enzyme requires glucosylated glycogenin as a primer; this is the reaction product of EC 2.4.1.186 (glycogenin glucosyltransferase). A similar enzyme utilizes ADP-glucose (EC 2.4.1.21, starch synthase).
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| Pathway |
| Starch and sucrose metabolism |
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| Orthology |
| glycogen(starch) synthase | | glycogen(starch) synthase | | phosphorylase / glycogen(starch) synthase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | API: | | PHU: | | ISC: | | CEL: | | CBR: | | BMY: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | CNE: | | CNB: | | CGI: | | LBC: | | MPR: | | CCI: | | SCM: | | UMA: | | PGR: | | MBR: | | DDI: | | DPP: | | GLA: | | DDS: | | DDN: | | DAS: | | LIP: | | SAT: | | BBE: | | DCA: | | MTU: | | MTV: | | MTC: | | MRA: | | MTF: | | MTB: | | MTK: | | MTZ: | | MTG: | | MTI: | | MTE: | | MTL: | | MTO: | | MTD: | | MTN: | | MTJ: | | MTUB: | | MBO: | | MBB: | | MBT: | | MBM: | | MBK: | | MAF: | | MCE: | | MCQ: | | MCV: | | MCX: | | MCZ: | | MLE: | | MLB: | | MPA: | | MAV: | | MIT: | | MIR: | | MIA: | | MID: | | MSG: | | MSA: | | MUL: | | MVA: | | MGI: | | MSP: | | MAB: | | MMV: | | MMC: | | MKM: | | MJL: | | MJD: | | MMI: | | MRH: | | MMM: | | MCB: | | MLI: | | ASD: | | NFA: | | NCY: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | GBR: | | GPO: | | GOR: | | TPR: | | SRT: | | SEN: | | SVI: | | AMD: | | AMN: | | AMM: | | PDX: | | AMI: | | SESP: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | CAI: | | SNA: | | CWO: | | AYM: | | SFC: | | OSP: | | AFD: | | SCN: | | CHU: | | DFE: | | SLI: | | LBY: | | RSI: | | EOL: | | FAE: | | MTT: | | COC: | | CCM: | | PHM: | | MOX: | |
» show all
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| Reference |
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| Authors |
ALGRANATI ID, CABIB E. |
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| Title |
The synthesis of glycogen in yeast. |
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| Journal |
Biochim. Biophys. Acta. 43 (1960) 141-2. |
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| Organism |
Ovis aries |
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| Reference |
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| Authors |
BASU DK, BACHHAWAT BK. |
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| Title |
Purification of uridine diphosphoglucose-glycogen transglucosylase from sheep brain. |
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| Journal |
Biochim. Biophys. Acta. 50 (1961) 123-8. |
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| Organism |
Saccharomyces cerevisiae [GN: sce] |
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| Reference |
3 |
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| Authors |
Leloir, L.F. and Cardini, C.E. |
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| Title |
UDPG-glycogen transglucosylase. |
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| Journal |
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 317-326. |
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| Reference |
|
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| Authors |
LELOIR LF, GOLDEMBERG SH. |
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| Title |
Synthesis of glycogen from uridine diphosphate glucose in liver. |
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| Journal |
J. Biol. Chem. 235 (1960) 919-23. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
Pitcher J, Smythe C, Cohen P. |
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| Title |
Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle. |
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| Journal |
Eur. J. Biochem. 176 (1988) 391-5. |
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| Organism |
Oryctolagus cuniculus |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9014-56-6 |
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