Entry
Name
xylosylprotein 4-beta-galactosyltransferase;
UDP-D-galactose:D-xylose galactosyltransferase;
UDP-D-galactose:xylose galactosyltransferase;
galactosyltransferase I;
uridine diphosphogalactose-xylose galactosyltransferase;
UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:O-beta-D-xylosyl-[protein] 4-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:[protein]-3-O-(beta-D-xylosyl)-L-serine 4-beta-D-galactosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + [protein]-3-O-(beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [RN:
R05926 ]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:
C00052 ];
[protein]-3-O-(beta-D-xylosyl)-L-serine
Product
UDP [CPD:
C00015 ];
[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
History
EC 2.4.1.133 created 1984, modified 2002
Pathway
ec00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
ec00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
Orthology
K00733 xylosylprotein 4-beta-galactosyltransferase
Genes
PTEH : 111521589(B4GALT7) 111534967
MORG : 121445746 121453401(B4galt7)
AML : 100466599(B4GALT7) 117800749
ZCA : 113929186(B4GALT7) 118356697
VPC : 102527005(B4GALT7) 102536649
AJM : 119035148(B4GALT7) 119046708
PDIC : 114510143(B4GALT7) 114510363
CCAE : 111935384(B4GALT7) 111944046
PMUR : 107294701(B4GALT7) 107295191
GJA : 107111554(B4GALT7) 107125262
XLA : 108710989(b4galt7.L) 495369(b4galt7.S)
SANH : 107662034 107664790
CCAR : 109095982 109095987
CAUA : 113057813 113089580 113114258
CGIB : 127971991 128027327
MASI : 127413449 127418004
GACU : 117550860 117562487(b4galt7)
SASA : 106604202(b4galt7) 106612238
STRU : 115167312(b4galt7) 115205710
OTW : 112221272(b4galt7) 112255876
SALP : 112069378 112080056
CCLU : 121530869 121538835(b4galt7)
PSPA : 121297175 121323785
ARUT : 117412848 117431368
SCLV : 120336078 120338772
LPIC : 129272379 129272380
DME : Dmel_CG11780(beta4GalT7)
DSI : Dsimw501_GD21157(Dsim_beta4GalT7)
DYA : Dyak_GE23542(Dyak_beta4GalT7)
DMO : Dmoj_GI22222(Dmoj_beta4GalT7)
BMOR : 101735491 101735627
BMAN : 114241485 114241539
BTAB : 109037025 109039279 109040034
SGRE : 126336658 126355065
PTEP : 107438664 107447873
CEL : CELE_R10E11.4(sqv-3)
CBR : CBG_09970(Cbr-sqv-3)
BMY : BM_BM5329(Bma-sqv-3)
PVUL : 126810665 126816332
MYI : 110455947 110455951 110462331 110462968
PMAX : 117339302 117341887
SHX : MS3_00007467(MCTS1_3)
MPP : MICPUCDRAFT_38613(JGI:MicpuC2_38613)
EHX : EMIHUDRAFT_197820 EMIHUDRAFT_197985
» show all
Taxonomy
Reference
Authors
Schwartz NB, Roden L.
Title
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans.
Journal
J Biol Chem 250:5200-7 (1975)
Reference
Authors
Okajima T, Yoshida K, Kondo T, Furukawa K
Title
Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.4.1.133