KEGG   ENZYME: 2.4.1.149Help
Entry
EC 2.4.1.149                Enzyme                                 

Name
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase;
poly-N-acetyllactosamine extension enzyme;
Galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase;
UDP-GlcNAc:GalR beta-D-3-N-acetylglucosaminyltransferase;
N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase;
UDP-GlcNAc:Galbeta1->4GlcNAcbeta-Rbeta1->3-N-acetylglucosaminyltransferase;
GnTE;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase;
beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine 3-beta-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R 3-beta N-acetylglucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R [RN:R02789]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R [CPD:C00694]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R [CPD:C04890]
Comment
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on glycoproteins, glycolipids, and oligosaccharides.
History
EC 2.4.1.149 created 1984 (EC 2.4.1.163 created 1989, incorporated 2016), modified 2016
Pathway
Glycosaminoglycan biosynthesis - keratan sulfate
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways
Orthology
K00741  
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
K07970  
beta-1,3-N-acetylglucosaminyltransferase 3
K07971  
beta-1,3-N-acetylglucosaminyltransferase 4
Genes
HSA: 
10331(B3GNT3) 10678(B3GNT2) 79369(B3GNT4)
PTR: 
455847(B3GNT3) 744166(B3GNT4) 745838(B3GNT2)
PPS: 
100973625(B3GNT2) 100982200(B3GNT4) 100982986(B3GNT3)
GGO: 
101126374(B3GNT4) 101130700(B3GNT2) 101151557(B3GNT3)
PON: 
100433243(B3GNT3) 100437574(B3GNT4) 100461200(B3GNT2)
NLE: 
100585350(B3GNT4) 100596245(B3GNT3) 100607325(B3GNT2)
MCC: 
693396(B3GNT2) 702023(B3GNT4) 719221(B3GNT3)
MCF: 
102134304(B3GNT3) 102136094(B3GNT2) 102138868(B3GNT4)
CSAB: 
103220181(B3GNT2) 103234153(B3GNT3) 103239303(B3GNT4)
RRO: 
104660961(B3GNT3) 104666296(B3GNT4) 104666963(B3GNT2)
CJC: 
100385332 100402866(LRRC43) 100404385(B3GNT3) 100407247(B3GNT2)
SBQ: 
101033879(B3GNT3) 101041127(B3GNT4) 101043174(B3GNT2) 104650627
MMU: 
231727(B3gnt4) 53625(B3gnt2) 72297(B3gnt3)
RNO: 
288752(B3gnt4) 290638(B3gnt3) 305571(B3gnt2)
CGE: 
100766691(B3gnt2) 100769077(B3gnt4) 100773213(B3gnt3)
NGI: 
103726889(B3gnt3) 103739056(B3gnt4) 103743255(B3gnt2)
HGL: 
101697436(B3gnt4) 101713138(B3gnt3) 101714518 101723595(B3gnt2)
OCU: 
100342947(B3GNT2) 103345065(B3GNT4)
TUP: 
102471847(B3GNT2) 102472378(B3GNT3) 102476277 102485148(B3GNT4)
CFA: 
474611(B3GNT2) 484831(B3GNT3) 486255(B3GNT4)
AML: 
100473756(B3GNT3) 100480301(B3GNT4) 100484275(B3GNT2)
UMR: 
103661263(B3GNT4) 103671308(B3GNT2) 103675168(B3GNT3)
FCA: 
101080523(B3GNT2) 101092089(B3GNT3) 101092795(B3GNT4)
PTG: 
102953748(B3GNT2) 102965987(B3GNT3) 102969555(B3GNT4)
BTA: 
515585(B3GNT2) 534619(B3GNT4) 784997(B3GNT3)
BOM: 
PHD: 
102337098(B3GNT2) 102344674(B3GNT4)
CHX: 
102168846(B3GNT4) 102171777(B3GNT3) 102172908(B3GNT2)
OAS: 
101102267(B3GNT4) 101113066(B3GNT3) 101117403(B3GNT2)
SSC: 
100518473(B3GNT3) 100524195(B3GNT2) 100623864 100739692(B3GNT4)
CFR: 
102506509(B3GNT2) 102512477(B3GNT3) 102519695(B3GNT4)
BACU: 
103010834(B3GNT4) 103012961(B3GNT3) 103013589(B3GNT2) 103018714
LVE: 
103079240(B3GNT2) 103080965(B3GNT3) 103086312(B3GNT4)
ECB: 
100060158(B3GNT4) 100064405(B3GNT2) 100146466(B3GNT3)
MYB: 
102254606(B3GNT3) 102258133(B3GNT4) 106723541(B3GNT2)
MYD: 
102762333(B3GNT2) 102767713(B3GNT3) 102772504(B3GNT4)
PALE: 
102879999(B3GNT2) 102882932(B3GNT3) 102898492(B3GNT4)
LAV: 
100656431(B3GNT2) 100667062(B3GNT4) 100673587(B3GNT3)
MDO: 
100010637(B3GNT3) 100022055(B3GNT4) 100031891(B3GNT2)
SHR: 
100920625(B3GNT3) 100928418(B3GNT2) 100929127(B3GNT4)
OAA: 
100074841(B3GNT4) 100078191(B3GNT2) 100086714
GGA: 
100858043(B3GNT4) 421286(B3GNT2)
MGP: 
100540421(B3GNT2) 100545749(B3GNT4) 100549756(B3GNT3)
CJO: 
107310873(B3GNT2) 107321114(B3GNT4) 107325454(B3GNT3)
APLA: 
101789872(B3GNT3) 101793948(B3GNT2) 101804408(B3GNT4)
TGU: 
100217506(B3GNT2) 100226631(B3GNT4)
GFR: 
102031557(B3GNT4) 102038254(B3GNT2)
FAB: 
101811159(B3GNT4) 101811829(B3GNT2)
PHI: 
102101528(B3GNT4) 102107608(B3GNT2)
CCW: 
104688690(B3GNT4) 104696618(B3GNT2)
FPG: 
101910333(B3GNT2) 101917583(B3GNT4) 106112886(B3GNT3)
FCH: 
102047111(B3GNT2) 102054592(B3GNT3) 102054954(B3GNT4)
CLV: 
102085751(B3GNT2) 102087378(B3GNT4) 102095902(B3GNT3)
AAM: 
106486607 106495676(B3GNT4) 106499878(B3GNT2)
ASN: 
102370599(B3GNT2) 102373956(B3GNT3) 102377528(B3GNT4)
AMJ: 
102572682(B3GNT4) 102573235(B3GNT2) 106737906(B3GNT3)
PSS: 
102443521(B3GNT3) 102444677(B3GNT4) 102453681 102460724(B3GNT2)
CMY: 
102933292 102935807(B3GNT4) 102936051(B3GNT2) 102944348(B3GNT3)
ACS: 
100554272(b3gnt2) 100566391(b3gnt4)
PBI: 
103052938(B3GNT2) 103061136(B3GNT3)
GJA: 
107115872(B3GNT4) 107120629(B3GNT3) 107121952(B3GNT2)
XLA: 
108703715 108705729(b3gnt4.S) 108711807 108716744(b3gnt4.L) 414647(b3gnt2.L) 446358(b3gnt2.S) 734264
XTR: 
100145701(b3gnt3) 100170561(b3gnt2) 100491670(b3gnt4) 100494334
DRE: 
100002020 561172(b3gnt3) 793362(b3gnt2b)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
BMY: 
LOA: 
CRG: 
 » show all
Taxonomy
Reference
1  [PMID:6219989]
  Authors
van den Eijnden DH, Winterwerp H, Smeeman P, Schiphorst WE.
  Title
Novikoff ascites tumor cells contain N-acetyllactosaminide beta 1 leads to 3 and beta 1 leads to 6 N-acetylglucosaminyltransferase activity.
  Journal
J. Biol. Chem. 258 (1983) 3435-7.
Reference
2  [PMID:6238026]
  Authors
Basu M, Basu S.
  Title
Biosynthesis in vitro of Ii core glycosphingolipids from neolactotetraosylceramide by beta 1-3- and beta 1-6-N-acetylglucosaminyltransferases from mouse T-lymphoma.
  Journal
J. Biol. Chem. 259 (1984) 12557-62.
Reference
3  [PMID:3160874]
  Authors
Takeya A, Hosomi O, Kogure T.
  Title
The presence of N-acetyllactosamine and lactose: beta (1-3)N-acetylglucosaminyltransferase activity in human urine.
  Journal
Jpn. J. Med. Sci. Biol. 38 (1985) 1-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
85638-39-7

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