KEGG   ENZYME: 2.4.1.149Help
Entry
EC 2.4.1.149                Enzyme                                 

Name
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase;
poly-N-acetyllactosamine extension enzyme;
Galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase;
UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase;
N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase;
UDP-GlcNAc:Galbeta1->4GlcNAcbeta-Rbeta1->3-N-acetylglucosaminyltransferase;
GnTE;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine 3-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R [RN:R02789]
Reaction(KEGG)
R02789 > R05974(G) R05975(G);
(other) R04659
Show
Substrate
UDP-N-acetyl-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R [CPD:C00694]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-R [CPD:C04890]
Comment
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and other glycoproteins and oligosaccharides.
History
EC 2.4.1.149 created 1984
Pathway
Glycosaminoglycan biosynthesis - keratan sulfate
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways
Orthology
K00741  
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
Genes
HSA: 
10678(B3GNT2)
PTR: 
745838(B3GNT2)
PPS: 
100973625(B3GNT2)
GGO: 
101130700(B3GNT2)
PON: 
100461200(B3GNT2)
NLE: 
100607325(B3GNT2)
MCC: 
693396(B3GNT2)
MCF: 
102136094(B3GNT2)
CSAB: 
103220181(B3GNT2)
RRO: 
104666963(B3GNT2)
CJC: 
SBQ: 
101043174(B3GNT2)
MMU: 
53625(B3gnt2)
RNO: 
305571(B3gnt2)
CGE: 
100766691(B3gnt2)
NGI: 
103743255(B3gnt2)
HGL: 
OCU: 
100342947(B3GNT2)
TUP: 
102471847(B3GNT2)
CFA: 
474611(B3GNT2)
AML: 
100484275(B3GNT2)
UMR: 
103671308(B3GNT2)
FCA: 
101080523(B3GNT2)
PTG: 
102953748(B3GNT2)
BTA: 
515585(B3GNT2)
BOM: 
PHD: 
102337098(B3GNT2)
CHX: 
102172908(B3GNT2)
OAS: 
101117403(B3GNT2)
SSC: 
CFR: 
102506509(B3GNT2)
BACU: 
LVE: 
103079240(B3GNT2)
ECB: 
100064405(B3GNT2)
MYB: 
106723541(B3GNT2)
MYD: 
102762333(B3GNT2)
PALE: 
102879999(B3GNT2)
LAV: 
100656431(B3GNT2)
MDO: 
100031891(B3GNT2)
SHR: 
100928418(B3GNT2)
OAA: 
100078191(B3GNT2)
GGA: 
421286(B3GNT2)
MGP: 
100540421(B3GNT2)
CJO: 
107310873(B3GNT2)
APLA: 
101793948(B3GNT2)
TGU: 
100217506(B3GNT2)
GFR: 
102038254(B3GNT2)
FAB: 
101811829(B3GNT2)
PHI: 
102107608(B3GNT2)
CCW: 
104696618(B3GNT2)
FPG: 
101910333(B3GNT2)
FCH: 
102047111(B3GNT2)
CLV: 
102085751(B3GNT2)
AAM: 
106499878(B3GNT2)
ASN: 
102370599(B3GNT2)
AMJ: 
102573235(B3GNT2)
PSS: 
CMY: 
ACS: 
100554272(b3gnt2)
PBI: 
103052938(B3GNT2)
GJA: 
107121952(B3GNT2)
XLA: 
414647(b3gnt2.L)
XTR: 
100170561(b3gnt2)
DRE: 
793362(b3gnt2b)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
CRG: 
 » show all
Taxonomy
Reference
1  [PMID:3160874]
  Authors
Takeya A, Hosomi O, Kogure T.
  Title
The presence of N-acetyllactosamine and lactose: beta (1-3)N-acetylglucosaminyltransferase activity in human urine.
  Journal
Jpn. J. Med. Sci. Biol. 38 (1985) 1-8.
Reference
2  [PMID:6219989]
  Authors
van den Eijnden DH, Winterwerp H, Smeeman P, Schiphorst WE.
  Title
Novikoff ascites tumor cells contain N-acetyllactosaminide beta 1 leads to 3 and beta 1 leads to 6 N-acetylglucosaminyltransferase activity.
  Journal
J. Biol. Chem. 258 (1983) 3435-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
85638-39-7

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