KEGG   ENZYME: 2.4.1.217Help
Entry
EC 2.4.1.217                Enzyme                                 
Name
mannosyl-3-phosphoglycerate synthase;
MPG synthase;
GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-mannose:3-phospho-D-glycerate 3-alpha-D-mannosyltransferase
Reaction(IUBMB)
GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate [RN:R05768]
Reaction(KEGG)
Substrate
GDP-mannose [CPD:C00096];
3-phospho-D-glycerate [CPD:C00197]
Product
GDP [CPD:C00035];
2-(alpha-D-mannosyl)-3-phosphoglycerate [CPD:C11516]
Comment
Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate.
Pathway
Fructose and mannose metabolism
Orthology
K05947  
mannosyl-3-phosphoglycerate synthase
Genes
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
PNO: 
PTE: 
RMR: 
RMG: 
DET: 
DET1363(mpgSP)
DEH: 
cbdb_A1314
DEB: 
DehaBAV1_1174
DEV: 
DhcVS_1144
DMC: 
btf_1241
DMD: 
dcmb_1222
DLY: 
Dehly_0877
TTH: 
TTC0588
TTJ: 
TTHA0954
TTS: 
Ththe16_0950
TTL: 
TtJL18_1098
MHD: 
Marky_0082
MFV: 
Mfer_0544
APO: 
Arcpr_0588
AVE: 
Arcve_0995 Arcve_1326
PHO: 
PH0927
PAB: 
PAB0816
PFU: 
PF0591
PFI: 
PFC_02085
PYN: 
PNA2_1454
PYA: 
PYCH_06950
PYS: 
Py04_0855
TGA: 
TGAM_0817
TSI: 
TSIB_0251
TBA: 
TERMP_00005
THA: 
TAM4_785
APE: 
APE_0889.1(mpgs)
SMR: 
Smar_0498
SHC: 
Shell_0304
NGA: 
Ngar_c27190(mngA2)
 » show all
Taxonomy
Reference
1  [PMID:11562374]
  Authors
Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS.
  Title
Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes.
  Journal
J. Biol. Chem. 276 (2001) 43580-8.
  Organism
Pyrococcus horikoshii [GN:pho]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
393512-63-5
DBGET integrated database retrieval system