KEGG   ENZYME: 2.4.1.217Help
Entry
EC 2.4.1.217                Enzyme                                 

Name
mannosyl-3-phosphoglycerate synthase;
MPG synthase;
GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-mannose:3-phospho-D-glycerate 3-alpha-D-mannosyltransferase
Reaction(IUBMB)
GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate [RN:R05768]
Reaction(KEGG)
Substrate
GDP-mannose [CPD:C00096];
3-phospho-D-glycerate [CPD:C00197]
Product
GDP [CPD:C00035];
2-(alpha-D-mannosyl)-3-phosphoglycerate [CPD:C11516]
Comment
Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate.
History
EC 2.4.1.217 created 2002
Pathway
ec00051  Fructose and mannose metabolism
Orthology
K05947  mannosyl-3-phosphoglycerate synthase
Genes
NCR: NCU05700
NTE: NEUTE1DRAFT100267(NEUTE1DRAFT_100267)
SMP: SMAC_02065
PAN: PODANSg2537
TTT: THITE_2120465
MTM: MYCTH_2303166
CTHR: CTHT_0072260
TMN: UCRPA7_732
CFJ: CFIO01_04083
ELA: UCREL1_10936
PTE: PTT_11203
ACTN: L083_6965
AFS: AFR_36880
DET: DET1363(mpgSP)
DEH: cbdbA1314
DMC: btf_1241
DMD: dcmb_1222
DMG: GY50_1201(mngA)
TTH: TT_C0588
TTJ: TTHA0954
RMR: Rmar_0502
MFV: Mfer_0544
PHO: PH0927(PH0927)
PAB: PAB0816
PFU: PF0591
PFI: PFC_02085
PYN: PNA2_1454
PYS: Py04_0855
TGA: TGAM_0817
TSI: TSIB_0251
THA: TAM4_785
TLT: OCC_09696
THS: TES1_0131
TNU: BD01_0152
PPAC: PAP_01435
APE: APE_0889.1(mpgs)
ACJ: ACAM_0578(mpgs)
SMR: Smar_0498
NGA: Ngar_c16030(mngA1) Ngar_c27190(mngA2)
NVN: NVIE_006110(mngA)
NEV: NTE_01978
NCV: NCAV_1295(mngA)
 » show all
Taxonomy
Reference
1  [PMID:11562374]
  Authors
Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS.
  Title
Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes.
  Journal
J. Biol. Chem. 276 (2001) 43580-8.
  Sequence
[pho:PH0927]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.217
IUBMB Enzyme Nomenclature: 2.4.1.217
ExPASy - ENZYME nomenclature database: 2.4.1.217
BRENDA, the Enzyme Database: 2.4.1.217
CAS: 393512-63-5

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