KEGG   ENZYME: 2.4.1.217Help
Entry
EC 2.4.1.217                Enzyme                                 

Name
mannosyl-3-phosphoglycerate synthase;
MPG synthase;
GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-mannose:3-phospho-D-glycerate 3-alpha-D-mannosyltransferase
Reaction(IUBMB)
GDP-mannose + 3-phospho-D-glycerate = GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate [RN:R05768]
Reaction(KEGG)
Substrate
GDP-mannose [CPD:C00096];
3-phospho-D-glycerate [CPD:C00197]
Product
GDP [CPD:C00035];
2-(alpha-D-mannosyl)-3-phosphoglycerate [CPD:C11516]
Comment
Requires Mg2+. The enzyme is absolutely specific for GDPmannose and 3-phosphoglycerate, and transfers the mannosyl group with retention of configuration. In the hyperthermophilic archaeon Pyrococcus horikoshii, the mannosyl-3-phosphoglycerate formed is subsequently dephosphorylated by a specific phosphatase, EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase), producing mannosylglycerate.
History
EC 2.4.1.217 created 2002
Pathway
Fructose and mannose metabolism
Orthology
K05947  
mannosyl-3-phosphoglycerate synthase
Genes
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
TMN: 
ELA: 
PNO: 
PTE: 
ACTN: 
AFS: 
RMR: 
RMG: 
DET: 
DET1363(mpgSP)
DEH: 
DEB: 
DEV: 
DMC: 
DMD: 
DMG: 
GY50_1201(mngA)
DLY: 
TTH: 
TTJ: 
TTS: 
TTL: 
MHD: 
MFV: 
APO: 
AVE: 
PHO: 
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TGA: 
TSI: 
TBA: 
THA: 
TLT: 
THS: 
TNU: 
APE: 
ACJ: 
ACAM_0578(mpgs)
SMR: 
SHC: 
NGA: 
Ngar_c16030(mngA1) Ngar_c27190(mngA2)
 » show all
Taxonomy
Reference
1  [PMID:11562374]
  Authors
Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS.
  Title
Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes.
  Journal
J. Biol. Chem. 276 (2001) 43580-8.
  Organism
Pyrococcus horikoshii
  Sequence
[pho:PH0927]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
393512-63-5

DBGET integrated database retrieval system