KEGG   ENZYME: 2.4.1.222Help
Entry
EC 2.4.1.222                Enzyme                                 

Name
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;
O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase;
fringe (ambiguous)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor [RN:R09296]
Reaction(KEGG)
R09296(G)
Show
Comment
O-Fucosylpeptide 3-beta-N-acetylglucosaminyltransferases are the products of fringe genes. O-linked fucose is an unusual form of glycosylation where the fucose is attached directly to proteins through the hydroxy groups of Ser or Thr residues.
History
EC 2.4.1.222 created 2002
Pathway
Other types of O-glycan biosynthesis
Orthology
K05948  
fringe
Genes
HSA: 
3955(LFNG) 4242(MFNG) 5986(RFNG)
PTR: 
458811(MFNG) 472272(LFNG) 747153(RFNG)
PPS: 
100977920(LFNG) 100980961(RFNG) 100995551(MFNG)
GGO: 
101145692(LFNG) 101150690(RFNG) 101151337(MFNG)
PON: 
MCC: 
MCF: 
MMU: 
16848(Lfng) 17305(Mfng) 19719(Rfng)
RNO: 
170905(Lfng) 315119(Mfng) 60433(Rfng)
CGE: 
HGL: 
101699763(Lfng) 101722987(Mfng) 101725480(Rfng)
TUP: 
102491172(LFNG) 102493487(RFNG) 102497808(MFNG)
CFA: 
483376(RFNG) 489891(LFNG) 610303(MFNG)
AML: 
FCA: 
PTG: 
102956076(RFNG) 102961069(MFNG) 102962200(LFNG)
BTA: 
505267(MFNG) 516209(LFNG) 532242(RFNG)
BOM: 
102276513(MFNG) 102286691(RFNG) 102288229(LFNG)
PHD: 
102323841(LFNG) 102342526(RFNG) 102344439(MFNG)
CHX: 
102169449(LFNG) 102178013(RFNG) 102178708(MFNG)
SSC: 
100524978(LFNG) 102161832(MFNG)
CFR: 
ECB: 
MYB: 
102238965(MFNG) 102250095(RFNG) 102261162(LFNG)
MYD: 
102761145(RFNG) 102764930(LFNG) 102767457(MFNG)
PALE: 
MDO: 
100012518(LFNG) 100025532(MFNG) 100029839(RFNG)
SHR: 
OAA: 
100078922(LFNG) 100093244(MFNG)
GGA: 
395789(RFNG) 395790(LFNG) 418042(MFNG)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
101790022(MFNG) 101800803(RFNG)
FPG: 
FCH: 
CLV: 
ASN: 
PSS: 
102443867(PsL-fng) 102455692(RFNG) 102458358(MFNG)
CMY: 
ACS: 
XLA: 
100036937(lfng) 394282(rfng) 397855(lfng)
XTR: 
100486895(rfng) 549805(lfng)
DRE: 
30158(lfng) 414848(rfng) 493633(mfng)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
551501(fng)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
BMY: 
LOA: 
AQU: 
 » show all
Taxonomy
Reference
1  [PMID:10935626]
  Authors
Moloney DJ, Panin VM, Johnston SH, Chen J, Shao L, Wilson R, Wang Y, Stanley P, Irvine KD, Haltiwanger RS, Vogt TF.
  Title
Fringe is a glycosyltransferase that modifies Notch.
  Journal
Nature. 406 (2000) 369-75.
  Organism
Drosophila melanogaster, Homo sapiens
  Sequence
[dme:Dmel_CG10580] [hsa:4242]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
299203-70-6

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