| Entry |
|
|---|
| Name |
glycoprotein 6-alpha-L-fucosyltransferase;
GDP-fucose---glycoprotein fucosyltransferase;
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1->6fucosyltransferase;
GDP-L-fucose-glycoprotein fucosyltransferase;
glycoprotein fucosyltransferase;
guanosine diphosphofucose-glycoprotein fucosyltransferase;
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked
N-acetylglucosamine of
4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-
acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-
mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-
glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase;
FucT;
GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked
N-acetylglucosamine of
N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-
acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-
mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-
glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
GDP-beta-L-fucose:glycoprotein (L-fucose to asparagine-linked
N-acetylglucosamine of
N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-a
cetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-man
nosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glu
cosaminyl}asparagine) 6-alpha-L-fucosyltransferase |
|---|
| Reaction(IUBMB) |
GDP-beta-L-fucose +
N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-
acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-
mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-
glucosaminyl}asparagine = GDP +
N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-
acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-
mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-
fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine [RN:R05988] |
|---|
| Reaction(KEGG) |
R05988(G)
 |
|---|
| Substrate |
GDP-beta-L-fucose [CPD:C00325];
N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-
acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-
mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-
glucosaminyl}asparagine |
|---|
| Product |
GDP [CPD:C00035];
N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-
acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-
mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-
fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine |
|---|
| Comment |
This enzyme catalyses a reaction similar to that of EC 2.4.1.214,
glycoprotein 3-alpha-L-fucosyltransferase, but transfers the
L-fucosyl group from GDP-beta-L-fucose to form an alpha1,6-linkage
rather than an alpha1,3-linkage. |
|---|
| Pathway |
ec00510 N-Glycan biosynthesis
ec00533 Glycosaminoglycan biosynthesis - keratan sulfate
ec01100 Metabolic pathways |
|---|
| Orthology |
K00717 glycoprotein 6-alpha-L-fucosyltransferase |
|---|
| Genes |
HSA: 2530(FUT8)
PTR: 449506(FUT8)
MCC: 708839(FUT8)
MMU: 53618(Fut8)
RNO: 432392(Fut8)
CFA: 448804(FUT8)
BTA: 281177(FUT8)
SSC: 396933(FUT8)
ECB: 100052546
MDO: 100012733 100022835
OAA: 100089222
GGA: 423178(FUT8)
TGU: 100229671
XLA: 394383(fut8-A) 779338(fut8)
XTR: 407913(fut8)
DRE: 797512(fut8)
BFO: BRAFLDRAFT_262109
CIN: 100175724 100176073 100178043(fut8) 100178416 100179900
100180987 100181649(FUT8) 100182126 100182761 100183863
100184175 100184572 100186705
SPU: 592434
DME: Dmel_CG2448(FucT6)
DPO: Dpse_GA15369(Dpse_FucT6)
DAN: Dana_GF21438
DER: Dere_GG18841
DPE: Dper_GL15236
DSE: Dsec_GM13053
DSI: Dsim_GD15979
DWI: Dwil_GK19791
DYA: Dyak_GE17606(Dyak_FucT6)
DGR: Dgri_GH24560
DMO: Dmoj_GI16320
DVI: Dvir_GJ15660
AAG: AaeL_AAEL008181
CQU: CpipJ_CPIJ008380
AME: 552522(FucT6)
NVI: 100114017(FucT6)
TCA: 657565
API: 100159908(ACYPI001248) 100160114(ACYPI001439)
100160201(ACYPI001516) 100163054(ACYPI004166)
100166386(ACYPI007263) 100166412(ACYPI007286)
100166593(ACYPI007452) 100168928(ACYPI009591)
PHU: Phum_PHUM392450
ISC: IscW_ISCW002476 IscW_ISCW003289
CEL: C10F3.6(fut-8)
CBR: CBG09273(Cbr-fut-8)
BMY: Bm1_22280
SMM: Smp_175120.1 Smp_175120.2
NVE: NEMVE_v1g164114
HMG: 100203172 100208727
TAD: TRIADDRAFT_2213 TRIADDRAFT_3280 TRIADDRAFT_32882
TRIADDRAFT_32887 TRIADDRAFT_32914 TRIADDRAFT_49632
TRIADDRAFT_60023
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:7083256]
Longmore GD, Schachter H.
Product-identification and substrate-specificity studies of the
GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside (FUC goes to
Asn-linked GlcNAc) 6-alpha-L-fucosyltransferase in a Golgi-rich
fraction from porcine liver.
Carbohydr. Res. 100 (1982) 365-92.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:3364733]
Voynow JA, Scanlin TF, Glick MC.
A quantitative method for GDP-L-Fuc:N-acetyl-beta-D-glucosaminide
alpha 1----6fucosyltransferase activity with lectin affinity
chromatography.
Anal. Biochem. 168 (1988) 367-73.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:8910378]
Uozumi N, Yanagidani S, Miyoshi E, Ihara Y, Sakuma T, Gao CX,
Teshima T, Fujii S, Shiba T, Taniguchi N.
Purification and cDNA cloning of porcine brain
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide
alpha1-->6fucosyltransferase.
J. Biol. Chem. 271 (1996) 27810-7.
Sus scofa [GN:ssc] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.68
IUBMB Enzyme Nomenclature: 2.4.1.68
ExPASy - ENZYME nomenclature database: 2.4.1.68
BRENDA, the Enzyme Database: 2.4.1.68
CAS: 9033-08-3 |
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