KEGG   ENZYME: 2.4.1.80Help
Entry
EC 2.4.1.80                 Enzyme                                 

Name
ceramide glucosyltransferase;
UDP-glucose:ceramide glucosyltransferase;
ceramide:UDP-Glc glucosyltransferase;
uridine diphosphoglucose-ceramide glucosyltransferase;
ceramide:UDP-glucose glucosyltransferase;
glucosylceramide synthase;
UDP-glucose:N-acylsphingosine D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:N-acylsphingosine beta-D-glucosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-glucose + an N-acylsphingosine = UDP + a beta-D-glucosyl-N-acylsphingosine [RN:R01497 R06275]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
N-acylsphingosine [CPD:C00195]
Product
UDP [CPD:C00015];
beta-D-glucosyl-N-acylsphingosine
Comment
Sphingosine and dihydrosphingosine can also act as acceptors; CDP-glucose can act as donor.
History
EC 2.4.1.80 created 1976
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K00720  ceramide glucosyltransferase
Genes
HSA: 7357(UGCG)
PTR: 464660(UGCG)
PPS: 100977415(UGCG)
GGO: 101150627(UGCG)
PON: 100433924(UGCG)
NLE: 100582032(UGCG)
MCC: 707875(UGCG)
MCF: 102118629(UGCG)
CSAB: 103219011(UGCG)
RRO: 104660866(UGCG)
RBB: 108517496(UGCG)
CJC: 100385999(UGCG)
SBQ: 101029543(UGCG)
MMU: 22234(Ugcg)
RNO: 83626(Ugcg)
CGE: 100689432(Ugcg)
NGI: 103732534(Ugcg)
HGL: 101716042(Ugcg)
CCAN: 109692884(Ugcg)
OCU: 100351712(UGCG)
TUP: 102473750(UGCG)
CFA: 481666(UGCG)
AML: 100476876(UGCG)
UMR: 103678658(UGCG)
ORO: 101368798(UGCG)
FCA: 101101006(UGCG)
PTG: 102958137(UGCG)
AJU: 106971763(UGCG)
BTA: 514357(UGCG)
BOM: 102270731(UGCG)
BIU: 109563343(UGCG)
PHD: 102344396(UGCG)
CHX: 102174936(UGCG)
OAS: 101111687(UGCG)
SSC: 100152737(UGCG)
CFR: 102523558(UGCG)
CDK: 105096380(UGCG)
BACU: 103012116(UGCG)
LVE: 103088786(UGCG)
OOR: 101272749(UGCG)
ECB: 100057611(UGCG)
EPZ: 103546872(UGCG)
EAI: 106826898(UGCG)
MYB: 102249980(UGCG)
MYD: 102753615(UGCG)
HAI: 109379357(UGCG)
RSS: 109456982(UGCG)
PALE: 102893957(UGCG)
LAV: 100661988(UGCG)
TMU: 101342311
MDO: 100018046(UGCG)
SHR: 100924812(UGCG)
OAA: 100081601(UGCG)
GGA: 427335(UGCG)
MGP: 100540621(UGCG)
CJO: 107306575(UGCG)
APLA: 101803473(UGCG)
ACYG: 106043037(UGCG)
TGU: 100222667(UGCG)
GFR: 102042412(UGCG)
FAB: 101820446(UGCG)
PHI: 102113021(UGCG)
PMAJ: 107216091(UGCG)
CCW: 104690512(UGCG)
FPG: 101913100(UGCG)
FCH: 102047010(UGCG)
CLV: 102093707(UGCG)
EGZ: 104123028(UGCG)
AAM: 106482556 106485124(UGCG)
ASN: 102386272(UGCG)
AMJ: 102575174(UGCG)
PSS: 102451150(UGCG)
CMY: 102936512(UGCG)
CPIC: 101936805(UGCG)
ACS: 100556823(ugcg)
PVT: 110077725(UGCG)
PBI: 103064708(UGCG)
GJA: 107118996(UGCG)
XLA: 399204(ugcg.L) 495444(ugcg.S)
XTR: 548887(ugcg)
NPR: 108798220(UGCG)
DRE: 553944(ugcg)
IPU: 108276755(ugcg)
AMEX: 103033150(ugcg)
TRU: 101072914(ugcg)
LCO: 104936383(ugcg)
MZE: 101472963(ugcg)
OLA: 101173189(ugcg)
XMA: 102237904(ugcg)
PRET: 103460445(ugcg)
NFU: 107374985(ugcg)
CSEM: 103390367(ugcg)
LCF: 108874619(ugcg)
HCQ: 109509121 109527845(ugcg)
BPEC: 110173717(ugcg)
ELS: 105020494(ugcg)
SFM: 108921932(ugcg)
LCM: 102362317(UGCG)
CMK: 103187139(ugcg)
CIN: 100181183
SPU: 591961
DME: Dmel_CG6437(GlcT-1)
DSI: Dsimw501_GD11642(Dsim_GD11642)
MDE: 101892563
AAG: 5565442
AME: 411552(GlcT-1)
BIM: 100742026
BTER: 100647986
SOC: 105198054
ACEP: 105624770
PBAR: 105424124
HST: 105186070
CFO: 105256622
LHU: 105667405
PGC: 109864211
NVI: 100117597(Glct-1)
TCA: 657299
DPA: 109540879
NVL: 108557617
BMOR: 101746025
PMAC: 106714974
PRAP: 111002713
PXY: 105388871
API: 100167638
DNX: 107161385
ZNE: 110838539
FCD: 110861770
TUT: 107366813
CEL: CELE_F20B4.6(cgt-2) CELE_F59G1.1(cgt-3) CELE_T06C12.10(cgt-1)
CBR: CBG02537(Cbr-cgt-3)
BMY: Bm1_44040
TSP: Tsp_10343
LAK: 106163876
EPA: 110255067
ADF: 107348280
HMG: 101234883
AQU: 100631446
LJA: Lj4g3v3044950.1(Lj4g3v3044950.1)
ERC: Ecym_4636
KMX: KLMA_20600(ugcg-b)
PIC: PICST_34303(CGT1)
CAL: CAALFM_C402010CA(HSX11)
CAUR: QG37_05706
SLB: AWJ20_1939(CGT1)
NCR: NCU01116
NTE: NEUTE1DRAFT57926(NEUTE1DRAFT_57926)
MGR: MGG_10668
MAW: MAC_04066
MAJ: MAA_01449
CMT: CCM_09521
MBE: MBM_02729
ANI: AN8806.2
ANG: ANI_1_1660064(An07g03380)
ABE: ARB_06972
TVE: TRV_00353
PTE: PTT_15097
CNE: CNH02280
CNB: CNBL2290
MRR: Moror_469
ABP: AGABI1DRAFT67520(AGABI1DRAFT_67520)
ABV: AGABI2DRAFT61534(AGABI2DRAFT_61534)
MGL: MGL_0042
YPE: YPO1983
YPK: y2328
YPA: YPA_1365
YPN: YPN_1463
YPM: YP_1831(wcaG7)
YPZ: YPZ3_1835
YPD: YPD4_1747
YPX: YPD8_1801
YPH: YPC_2339
YPW: CH59_4147
YPJ: CH55_756
YPV: BZ15_1558
YPL: CH46_3132
YPS: YPTB1976
YPO: BZ17_493
YPY: YPK_2212
YPB: YPTS_2031
YPQ: DJ40_337
YPU: BZ21_1252
YPR: BZ20_139
YPC: BZ23_1533
YPF: BZ19_1324
RAA: Q7S_11875
XCC: XCC2437
XCB: XC_1675
XCA: xcc-b100_1729(ugcG)
XCP: XCR_2750
XCV: XCV2767
XAX: XACM_2550
XAC: XAC2568
XPH: XppCFBP6546_19555(XppCFBP6546P_19555)
LFA: LFA_3674
NTT: TAO_1020
REH: H16_B2171(h16_B2171)
CNC: CNE_2c21560(rfaG)
RME: Rmet_3407
CGD: CR3_3471
BMAL: DM55_549
BMAQ: DM76_530
BPR: GBP346_A0212(hpnI_1) GBP346_A2918(hpnI_2)
BCN: Bcen_0691
BCJ: BCAL1050
BCEW: DM40_1835
BCEO: I35_1042
BAM: Bamb_1049
BMU: Bmul_2134
BMJ: BMULJ_01110(ugcG)
BMK: DM80_467
BMUL: NP80_1276
BCED: DM42_552
BDL: AK34_1984
BUB: BW23_560
BLAT: WK25_05580
BSTG: WT74_05875
BYI: BYI23_A022790(hpnI)
BBAG: E1O_05360
GSU: GSU0697(hpnI)
GSK: KN400_0673(hpnI)
GME: Gmet_2815(hpnI)
GUR: Gura_1031
GLO: Glov_3180
GBM: Gbem_3357(hpnI)
GEO: Geob_3659(hpnI)
GEM: GM21_0888
GEB: GM18_3436
PPD: Ppro_0563
ADE: Adeh_0896
MXA: MXAN_4793
SCL: sce9238(ugcG)
MLO: mlr5650
ATU: Atu1808(ugcG)
ATF: Ach5_17330(ugcG)
AGR: AGROH133_06859(ugcG)
RHT: NT26_1263
SHZ: shn_08500
MOR: MOC_1191(hpnI) MOC_4411
RVA: Rvan_3167
HDI: HDIA_2738
RSP: RSP_2152
KVU: EIO_1630
KVL: KVU_1102
KRO: BVG79_01344(ugcG)
ZMO: ZMO0972
ZMN: Za10_0329
ZMM: Zmob_0334
ZMB: ZZ6_0334
ZMI: ZCP4_0344
SPHM: G432_09210
GOX: GOX0615
GOH: B932_0704
GOY: GLS_c07060(hpnI)
ACR: Acry_1835
GDI: GDI0719
GDJ: Gdia_1291
GXY: GLX_13930
GXL: H845_2660
KEU: S101446_01972(ugcG)
ASZ: ASN_2055
ABG: Asbog_00209(hpnI)
MAG: amb3484
MAGX: XM1_4360
MAGN: WV31_00815
AFR: AFE_2121
ACU: Atc_2237
SSA: SSA_1324
STJ: SALIVA_1338(FNV0895)
TACI: TDSAC_0612
CFI: Celf_3210
PSIM: KR76_04775
SYN: slr0813
SYY: SYNGTS_1546(slr0813)
SYT: SYNGTI_1546(slr0813)
SYS: SYNPCCN_1545(slr0813)
SYQ: SYNPCCP_1545(slr0813)
TEL: tll0064
THN: NK55_09535(hpnI)
LBO: LBWT_980
AMR: AM1_5794
CYT: cce_0751
ANB: ANA_C13146(hpnI)
CEO: ETSB_1001
HAU: Haur_0401
IPA: Isop_1743
SACI: Sinac_5235
FNU: FN1845
LBA: Lebu_1741
MRO: MROS_0639
CABY: Cabys_1351
 » show all
Taxonomy
Reference
1  [PMID:4631392]
  Authors
Basu S, Kaufman B, Roseman S.
  Title
Enzymatic synthesis of glucocerebroside by a glucosyltransferase from embryonic chicken brain.
  Journal
J. Biol. Chem. 248 (1973) 1388-94.
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.80
IUBMB Enzyme Nomenclature: 2.4.1.80
ExPASy - ENZYME nomenclature database: 2.4.1.80
BRENDA, the Enzyme Database: 2.4.1.80
CAS: 37237-44-8

DBGET integrated database retrieval system