KEGG   ENZYME: 2.4.1.90Help
Entry
EC 2.4.1.90                 Enzyme                                 

Name
N-acetyllactosamine synthase;
UDP-galactose---N-acetylglucosamine beta-D-galactosyltransferase;
uridine diphosphogalactose-acetylglucosamine galactosyltransferase;
beta-1,4-galactosyltransferase;
acetyllactosamine synthetase;
lactosamine synthase;
lactosamine synthetase;
lactose synthetase A protein;
N-acetyllactosamine synthetase;
UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase;
UDP-galactose-acetylglucosamine galactosyltransferase;
UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase;
UDP-galactose-N-acetylglucosamine galactosyltransferase;
beta1-4-galactosyltransferase;
UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase;
beta1-4GalT;
NAL synthetase;
UDP-beta-1,4-galactosyltransferase;
Gal-T;
UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase;
UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase;
beta-N-acetylglucosaminide beta1-4-galactosyltransferase;
UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine [RN:R01205 R06055]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-D-glucosamine [CPD:C00140]
Product
UDP [CPD:C00015];
N-acetyllactosamine [CPD:C00611]
Comment
The reaction is catalysed by a component of EC 2.4.1.22 (lactose synthase), which is identical with EC 2.4.1.38 (beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase), and by an enzyme from the Golgi apparatus of animal tissues. Formerly listed also as EC 2.4.1.98.
History
EC 2.4.1.90 created 1976 (EC 2.4.1.98 created 1980, incorporated 1984)
Orthology
K07966  
beta-1,4-galactosyltransferase 1
K07967  
beta-1,4-galactosyltransferase 2
K07968  
beta-1,4-galactosyltransferase 3
K07969  
beta-1,4-galactosyltransferase 4
Genes
HSA: 
2683(B4GALT1) 8702(B4GALT4) 8703(B4GALT3) 8704(B4GALT2)
PTR: 
100608173(B4GALT4) 100613700(B4GALT1) 456522(B4GALT2) 457451(B4GALT3)
PPS: 
100974756(B4GALT1) 100980267(B4GALT2) 100980499(B4GALT3) 100994562(B4GALT4)
GGO: 
101133326(B4GALT2) 101138982(B4GALT1) 101146705(B4GALT4) 101147565 101152694(B4GALT3)
PON: 
100174763(B4GALT3) 100437696(B4GALT2) 100438031(B4GALT1) 100443591(B4GALT4)
NLE: 
100597531(B4GALT1) 100598306(B4GALT2) 100600025(B4GALT4) 100600657(B4GALT3)
MCC: 
703541(B4GALT1) 704038(B4GALT2) 711983(B4GALT4) 719920(B4GALT3)
MCF: 
102115300(B4GALT2) 102123574(B4GALT3) 102131044(B4GALT1) 102142820(B4GALT4)
CSAB: 
103219294(B4GALT1) 103223692(B4GALT3) 103224947(B4GALT2) 103228234(B4GALT4)
RRO: 
104657610(B4GALT4) 104665338(B4GALT3) 104669045(B4GALT2) 104674271(B4GALT1)
CJC: 
100385157(B4GALT1) 100402903(B4GALT4) 100413633(B4GALT3) 100414763 100896540(B4GALT2)
SBQ: 
101029385(B4GALT4) 101039415(B4GALT2) 101048901(B4GALT3) 101054125(B4GALT1)
MMU: 
14595(B4galt1) 53418(B4galt2) 56375(B4galt4) 57370(B4galt3)
RNO: 
24390(B4galt1) 303923(B4galt4) 313536(B4galt2) 494342(B4galt3)
CGE: 
100689346(B4galt3) 100689430(B4galt1) 100689434(B4galt2) 100689435(B4galt4)
NGI: 
103741594(B4galt1) 103741937(B4galt4) 103743868(B4galt2) 103745954(B4galt3)
HGL: 
101698779 101702700(B4galt3) 101718811(B4galt2) 101721414(B4galt1) 101723638(B4galt4)
OCU: 
100345726(B4GALT1) 100351419(B4GALT2) 100357504(B4GALT4) 100358436(B4GALT3)
TUP: 
102470291(B4GALT4) 102470655(B4GALT1) 102489782(B4GALT2) 102501629(B4GALT3)
CFA: 
476397 481579(B4GALT1) 482527(B4GALT2) 488650(B4GALT3) 608143(B4GALT4)
AML: 
100471634(B4GALT2) 100477164(B4GALT1) 100479119 100481658(B4GALT4) 100482718(B4GALT3)
UMR: 
103657308 103667105(B4GALT1) 103670800(B4GALT2) 103672017(B4GALT3) 103678795(B4GALT4)
FCA: 
101084809(B4GALT2) 101089738(B4GALT3) 101100325(B4GALT4) 101100927(B4GALT1)
PTG: 
102955088(B4GALT2) 102959538(B4GALT1) 102965736(B4GALT3) 102966539(B4GALT4)
BTA: 
100125390(B4GALT2) 281781(B4GALT1) 511328(B4GALT4) 515771(B4GALT3)
BOM: 
102269762(B4GALT1) 102273575(B4GALT3) 102279871(B4GALT4) 102283249(B4GALT2)
PHD: 
102317609(B4GALT2) 102321948(B4GALT1) 102340702(B4GALT4) 102343232(B4GALT3)
CHX: 
100860927(B4GALT1) 102190262(B4GALT4) 102191101(B4GALT2) 102191287(B4GALT3)
OAS: 
100620048(B4GALT1) 101103686(B4GALT3) 101104949(B4GALT4) 101114825(B4GALT2)
SSC: 
100154856(B4GALT3) 100511655(B4GALT1) 100514465 100736821(B4GALT2)
CFR: 
102510375(SIGLEC6) 102516080(B4GALT2) 102517623(B4GALT1) 102522848(B4GALT4) 102523348(B4GALT3)
BACU: 
102999260(B4GALT1) 103001417(B4GALT2) 103005928(B4GALT4) 103014433(B4GALT3)
LVE: 
103083911(B4GALT3) 103084555(B4GALT4) 103086401(B4GALT1) 103086978(B4GALT2)
ECB: 
100065936 100066144(B4GALT3) 100066149(B4GALT2) 100068209(B4GALT1) 100071082(B4GALT4)
MYB: 
102240062(B4GALT1) 102243483(B4GALT4) 102245477(B4GALT3) 102248727(B4GALT2)
MYD: 
102751484(B4GALT1) 102755410 102770964(B4GALT3) 102772464 102774860(B4GALT2) 102775104(B4GALT4)
PALE: 
102878748(B4GALT1) 102879802(B4GALT4) 102884318(B4GALT2) 102897413(B4GALT3)
LAV: 
100657659(B4GALT2) 100659897(B4GALT1) 100662008(B4GALT4) 100666904 100671768(B4GALT3)
MDO: 
100010600(B4GALT1) 100015888(B4GALT4) 100028240 100032749(B4GALT3) 100617718(B4GALT2)
SHR: 
100917085(B4GALT3) 100918732(B4GALT2) 100929465(B4GALT1) 100933479(B4GALT4) 100934965
OAA: 
100075607 100075703(B4GALT1) 100092000(B4GALT2)
GGA: 
396121(B4GALT1) 396122(B4GALT2) 418341(B4GALT4) 418342(B4GALT3)
MGP: 
100543545(B4GALT1) 100543680(B4GALT2) 100547867(B4GALT4) 100548019
CJO: 
107306674(B4GALT1) 107307393 107317480(B4GALT2) 107320407(B4GALT4) 107320437
APLA: 
101792176(B4GALT4) 101792630 101792817(B4GALT1) 101802590(B4GALT2) 101803398
TGU: 
100219809 100223650(B4GALT1) 100230291(B4GALT4) 100230857(B4GALT2)
GFR: 
102034619 102034782(B4GALT4) 102035894(B4GALT3) 102036032(B4GALT2) 102041517(B4GALT1)
FAB: 
101805871(B4GALT2) 101807052(B4GALT1) 101809643 101809954(B4GALT4)
PHI: 
102104795(B4GALT3) 102106294(B4GALT2) 102108146(B4GALT4) 102108330 102109081(B4GALT1)
CCW: 
104687053(B4GALT4) 104687054(B4GALT3) 104689823(B4GALT1) 104695261(B4GALT2)
FPG: 
101910439(B4GALT3) 101915659(B4GALT4) 101915824 101916596(B4GALT2) 101918852(B4GALT1)
FCH: 
102046112(B4GALT1) 102051115(B4GALT4) 102051290 102056545(B4GALT2) 102057757(B4GALT3)
CLV: 
102088289(B4GALT1) 102088677(B4GALT2) 102093764(B4GALT4) 102093948 102094059(B4GALT3)
AAM: 
106484931(B4GALT2) 106486901(B4GALT1) 106490693 106490705(B4GALT4) 106500494(B4GALT3)
ASN: 
102370415 102370808(B4GALT4) 102371026 102372956(B4GALT1) 102376584(B4GALT2) 102388067(B4GALT3)
AMJ: 
102558168(B4GALT2) 102559129(B4GALT1) 102569919(B4GALT4) 102572436 102575172(B4GALT3) 106737239(B4GALT3)
PSS: 
102448865(B4GALT3) 102450039 102453780(B4GALT4) 102459690(B4GALT1) 102461193
CMY: 
102937222(B4GALT3) 102941460 102941864(B4GALT2) 102942662(B4GALT1) 102946330(B4GALT4)
ACS: 
100553459 100553568(b4galt4) 100557158 100557558(b4galt2) 100558708(b4galt3) 100561064(b4galt1)
PBI: 
103050267 103063173(B4GALT3) 103065477(B4GALT1) 103068003 103068176(B4GALT4) 103068203(B4GALT2)
GJA: 
107106045(B4GALT4) 107106046 107110573(B4GALT1) 107120293(B4GALT2) 107121751(B4GALT3) 107122018
XLA: 
100190782(b4galt2.S) 379106(MGC52827) 414540 444709(b4galt4.S) 446718(b4galt3.L) 496041
XTR: 
100145518(b4galt1.1) 100486704 100488464(b4galt4) 100492356(b4galt2) 448369(b4galt3) 549418(b4galt1.2) 733985(b4galt3)
DRE: 
100148828(b4galt2) 492760(b4galt4) 550425(b4galt1) 556544(fd56f09) 561756(b4galt3) 768123(b4galt1l)
TRU: 
TNG: 
MZE: 
OLA: 
100301598(b4galt2) 101159351(b4galt3) 101162708 101164915(b4galt4) 101171148(b4galt1)
XMA: 
SASA: 
LCM: 
CMK: 
BFO: 
CIN: 
PXY: 
PHU: 
DPX: 
ISC: 
CEL: 
CBR: 
CBG22165(Cbr-bre-4)
BMY: 
LOA: 
HRO: 
CRG: 
OBI: 
SMM: 
ADF: 
 » show all
Taxonomy
Reference
1  [PMID:99178]
  Authors
Deshmukh DS, Bear WD, Soifer D.
  Title
Isolation and characterization of an enriched Golgi fraction from rat brain.
  Journal
Biochim. Biophys. Acta. 542 (1978) 284-95.
Reference
2  [PMID:4631039]
  Authors
Helting T, Erbing B.
  Title
Galactosyltransfer in mouse mastocytoma: purification and properties of N-acetyllactosamine synthetase.
  Journal
Biochim. Biophys. Acta. 293 (1973) 94-104.
Reference
3  [PMID:812340]
  Authors
Hill RL, Brew K.
  Title
Lactose synthetase.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 43 (1975) 411-90.
Reference
4  [PMID:6201486]
  Authors
Humphreys-Beher MG.
  Title
Isolation and characterization of UDP-galactose:N-acetylglucosamine 4 beta-galactosyltransferase activity induced in rat parotid glands treated with isoproterenol.
  Journal
J. Biol. Chem. 259 (1984) 5797-802.
Reference
5  [PMID:4392041]
  Authors
Schachter H, Jabbal I, Hudgin RL, Pinteric L, McGuire EJ, Roseman S.
  Title
Intracellular localization of liver sugar nucleotide glycoprotein glycosyltransferases in a Golgi-rich fraction.
  Journal
J. Biol. Chem. 245 (1970) 1090-100.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9054-94-8

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