KEGG   ENZYME: 2.4.99.20Help
Entry
EC 2.4.99.20                Enzyme                                 

Name
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase;
diphosphopyridine nucleosidase (ambiguous);
CD38 (gene name);
BST1 (gene name)
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
NADP+:nicotinate ADP-ribosyltransferase
Reaction(IUBMB)
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide (overall reaction) [RN:R00119];
(1a) NADP+ = 2'-phospho-cyclic ADP-ribose + nicotinamide [RN:R10631];
(1b) 2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate [RN:R10632]
Reaction(KEGG)
Substrate
NADP+ [CPD:C00006];
nicotinate [CPD:C00253];
2'-phospho-cyclic ADP-ribose [CPD:C20742]
Product
nicotinate-adenine dinucleotide phosphate [CPD:C13051];
nicotinamide [CPD:C00153];
2'-phospho-cyclic ADP-ribose [CPD:C20742]
Comment
This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
History
EC 2.4.99.20 created 2014
Pathway
Nicotinate and nicotinamide metabolism
Orthology
K01242  
ADP-ribosyl cyclase 1
K18152  
ADP-ribosyl cyclase 2
Genes
HSA: 
683(BST1) 952(CD38)
PTR: 
461126(BST1) 745433(CD38)
PPS: 
100972434(BST1) 100974952(CD38)
GGO: 
PON: 
100174150(BST1) 100457558(CD38)
NLE: 
100606064(BST1) 100606960(CD38)
MCC: 
714399(CD38) 722848(BST1)
MCF: 
101926698(BST1) 102126394(CD38)
CSAB: 
103246326(CD38) 103246328(BST1)
RRO: 
104658167(BST1) 104658170(CD38)
CJC: 
100387937(CD38) 100402445(BST1)
SBQ: 
101035567(BST1) 101036203(CD38)
MMU: 
12182(Bst1) 12494(Cd38)
RNO: 
25668(Cd38) 81506(Bst1)
CGE: 
100773187(Cd38) 100773468(Bst1)
NGI: 
103728882(Cd38) 103728884(Bst1)
HGL: 
101713685(Bst1) 101720283(Cd38)
OCU: 
100009409(CD38) 100351817(BST1)
TUP: 
102468679(BST1) 102480083(CD38)
CFA: 
403756(CD38) 488820(BST1)
AML: 
100463977(BST1) 100481326(CD38)
UMR: 
103658313(BST1) 103658362(CD38)
FCA: 
101101052(BST1) 101101308(CD38)
PTG: 
102955186(CD38) 102962771(BST1)
BTA: 
327677(CD38) 616757(BST1)
BOM: 
102271683(BST1) 102273331(CD38)
PHD: 
102322294(CD38) 102322993(BST1)
CHX: 
102169848(BST1) 102172881(CD38)
OAS: 
101116575(BST1)
SSC: 
100511702(CD38) 100625942(BST1)
CFR: 
102508026(CD38) 102508256(BST1)
BACU: 
103000954(BST1) 103020545(CD38)
LVE: 
103087769(CD38) 103088314(BST1)
ECB: 
100068959(CD38) 100068968(BST1)
MYB: 
102252244(CD38) 102252530(BST1)
MYD: 
102759158(CD38) 102770056(BST1)
PALE: 
102884937(BST1) 102889755(CD38)
LAV: 
100659997(BST1) 100660287(CD38)
MDO: 
100015733(BST1) 103094598(CD38)
SHR: 
100915627(BST1) 105751033(CD38)
OAA: 
100074315(CD38) 100079912(BST1)
GGA: 
422827(CD38) 422828(BST1)
MGP: 
100546297(BST1) 100548136(CD38)
CJO: 
107313950(BST1) 107313951(CD38)
APLA: 
101799363(BST1)
TGU: 
100224783(BST1) 101232999(CD38)
GFR: 
102032481(BST1) 102032646(CD38)
FAB: 
101808664(BST1) 101813225(CD38)
PHI: 
102100836(CD38) 102101014(BST1)
CCW: 
104690721(BST1) 104690901(CD38)
FPG: 
101912278(CD38) 101917967(BST1)
FCH: 
102048375(CD38) 102048871(BST1)
CLV: 
102089666(CD38) 102089855(BST1)
AAM: 
ASN: 
102376962(BST1) 102377198(CD38)
AMJ: 
102559494(BST1) 102565250(CD38)
PSS: 
102444728(BST1) 102444963(CD38)
CMY: 
102933631(BST1) 102933862(CD38)
ACS: 
100566030(cd38)
PBI: 
103059310(CD38)
GJA: 
107120012(CD38)
XLA: 
100036901(cd38.L) 100873156(cd38b) 101027297(cd157)
XTR: 
101733556(bst1) 496666(cd38)
DRE: 
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
SPU: 
100126187(arc3) 100859964(arc4) 576085(arc2) 580868(arc1)
HRO: 
LGI: 
CRG: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
 » show all
Taxonomy
Reference
1  [PMID:11829748]
  Authors
Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H
  Title
CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.
  Journal
Biochem. J. 362 (2002) 125-30.
  Sequence
[mmu:12494]
Reference
2  [PMID:16690024]
  Authors
Moreschi I, Bruzzone S, Melone L, De Flora A, Zocchi E
  Title
NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases.
  Journal
Biochem. Biophys. Res. Commun. 345 (2006) 573-80.
  Sequence
[hsa:952]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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