EC                Enzyme                                 

2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase;
diphosphopyridine nucleosidase (ambiguous);
CD38 (gene name);
BST1 (gene name)
Transferring other glycosyl groups
BRITE hierarchy
NADP+:nicotinate ADP-ribosyltransferase
NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide (overall reaction) [RN:R00119];
(1a) NADP+ = 2'-phospho-cyclic ADP-ribose + nicotinamide [RN:R10631];
(1b) 2'-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate [RN:R10632]
NADP+ [CPD:C00006];
nicotinate [CPD:C00253];
2'-phospho-cyclic ADP-ribose [CPD:C20742]
nicotinate-adenine dinucleotide phosphate [CPD:C13051];
nicotinamide [CPD:C00153];
2'-phospho-cyclic ADP-ribose [CPD:C20742]
This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
EC created 2014
ec00760  Nicotinate and nicotinamide metabolism
K01242  ADP-ribosyl cyclase 1
K18152  ADP-ribosyl cyclase 2
HSA: 683(BST1) 952(CD38)
PTR: 461126(BST1) 745433(CD38)
PPS: 100972434(BST1) 100974952(CD38)
GGO: 101145401(BST1) 101149825(CD38)
PON: 100174150(BST1) 100457558(CD38)
NLE: 100606064(BST1) 100606960(CD38)
MCC: 714399(CD38) 722848(BST1)
MCF: 101926698(BST1) 102126394(CD38)
CSAB: 103246326(CD38) 103246328(BST1)
RRO: 104658167(BST1) 104658170(CD38)
RBB: 108531741(CD38) 108531746(BST1)
CJC: 100387937(CD38) 100402445(BST1)
SBQ: 101035567(BST1) 101036203(CD38)
MMU: 12182(Bst1) 12494(Cd38)
RNO: 25668(Cd38) 81506(Bst1)
CGE: 100773187(Cd38) 100773468(Bst1)
NGI: 103728882(Cd38) 103728884(Bst1)
HGL: 101713685(Bst1) 101720283(Cd38)
CCAN: 109691561(Cd38) 109691564(Bst1)
OCU: 100009409(CD38) 100351817(BST1)
TUP: 102468679(BST1) 102480083(CD38)
CFA: 403756(CD38) 488820(BST1)
AML: 100463977(BST1) 100481326(CD38)
UMR: 103658313(BST1) 103658362(CD38)
ORO: 101364829(CD38) 101365133(BST1)
FCA: 101101052(BST1) 101101308(CD38)
PTG: 102955186(CD38) 102962771(BST1)
AJU: 106975627(BST1) 106975653(CD38)
BTA: 327677(CD38) 616757(BST1)
BOM: 102271683(BST1) 102273331(CD38)
BIU: 109560088(BST1) 109560687(CD38)
PHD: 102322294(CD38) 102322993(BST1)
CHX: 102169848(BST1) 102172881(CD38)
OAS: 101116575(BST1)
SSC: 100511702(CD38) 100625942(BST1)
CFR: 102508026(CD38) 102508256(BST1)
CDK: 105098338(BST1) 105098339(CD38)
BACU: 103000954(BST1) 103020545(CD38)
LVE: 103087769(CD38) 103088314(BST1)
OOR: 101284537(CD38) 101284786(BST1)
ECB: 100068959(CD38) 100068968(BST1)
EPZ: 103565758(BST1) 103565759(CD38)
EAI: 106827091(CD38) 106827092(BST1)
MYB: 102252244(CD38) 102252530(BST1)
MYD: 102759158(CD38) 102770056(BST1)
HAI: 109372167(CD38) 109372831(BST1)
RSS: 109435264(CD38) 109452142(BST1)
PALE: 102884937(BST1) 102889755(CD38)
LAV: 100659997(BST1) 100660287(CD38)
MDO: 100015733(BST1) 103094598(CD38)
SHR: 100915627(BST1) 105751033(CD38)
OAA: 100074315(CD38) 100079912(BST1)
GGA: 422827(CD38) 422828(BST1)
MGP: 100546297(BST1) 100548136(CD38)
CJO: 107313950(BST1) 107313951(CD38)
APLA: 101799363(BST1)
ACYG: 106033418(CD38) 106035386(BST1)
TGU: 100224783(BST1) 101232999(CD38)
GFR: 102032481(BST1) 102032646(CD38)
FAB: 101808664(BST1) 101813225(CD38)
PHI: 102100836(CD38) 102101014(BST1)
CCW: 104690721 104690901(CD38)
FPG: 101912278(CD38) 101917967(BST1)
FCH: 102048375(CD38) 102048871(BST1)
CLV: 102089855(BST1)
EGZ: 104134476(BST1) 104134477(CD38)
ASN: 102376962(BST1) 102377198(CD38)
AMJ: 102559494(BST1)
PSS: 102444728(BST1) 102444963(CD38)
CMY: 102933631(BST1) 102933862(CD38)
CPIC: 101935271(BST1) 101935553(CD38)
ACS: 100566030(cd38)
PVT: 110085956(CD38)
PBI: 103059310(CD38)
GJA: 107120012(CD38)
XLA: 100036901(cd38.L) 100873156(cd38b) 101027297(bst1.L)
XTR: 101733556(bst1) 496666(cd38)
NPR: 108799310(BST1) 108799313
DRE: 101886891
SRX: 107750973(cd38)
SANH: 107693813
SGH: 107568972
CCAR: 109104929(cd38)
AMEX: 103029242
HCQ: 109517521
ELS: 105031580
CMK: 103175800
SPU: 100126187(arc3) 100859964(arc4) 576085(arc2) 580868(arc1)
SKO: 100370260
CRG: 105319809
 » show all
1  [PMID:11829748]
Chini EN, Chini CC, Kato I, Takasawa S, Okamoto H
CD38 is the major enzyme responsible for synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues.
Biochem. J. 362 (2002) 125-30.
2  [PMID:16690024]
Moreschi I, Bruzzone S, Melone L, De Flora A, Zocchi E
NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases.
Biochem. Biophys. Res. Commun. 345 (2006) 573-80.
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