KEGG   ENZYME: 2.4.99.4Help
Entry
EC 2.4.99.4                 Enzyme                                 
Name
beta-galactoside alpha-2,3-sialyltransferase;
CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:beta-D-galactoside alpha-(2->3)-N-acetylneuraminyl-transferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R [RN:R04590 R05913]
Reaction(KEGG)
R04590 R05913(G);
(other) R04648 R05116 R05942(G) R05949(G) R05957(G) R05967(G)
Show
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
Comment
The acceptor is Galbeta1,3GalNAc-R, where R is H, a threonine or serine residue in a glycoprotein, or a glycolipid. Lactose can also act as acceptor. May be identical with EC 2.4.99.2 monosialoganglioside sialyltransferase.
Pathway
Mucin type O-Glycan biosynthesis
Glycosaminoglycan biosynthesis - keratan sulfate
Glycosphingolipid biosynthesis - lacto and neolacto series
Glycosphingolipid biosynthesis - globo series
Glycosphingolipid biosynthesis - ganglio series
Metabolic pathways
Orthology
K00780  
beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A)
K03368  
beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4B)
K03494  
beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4C)
Genes
HSA: 
6482(ST3GAL1) 6483(ST3GAL2) 6484(ST3GAL4)
PTR: 
450114(ST3GAL1) 454214(ST3GAL2) 466845(ST3GAL4)
PPS: 
100973080(ST3GAL4) 100981168(ST3GAL2) 100987531(ST3GAL1)
GGO: 
101130368(ST3GAL2) 101141340(ST3GAL4) 101152668(ST3GAL1)
PON: 
100172032(ST3GAL4) 100438644(ST3GAL1) 100457161(ST3GAL2)
MCC: 
698004(ST3GAL1) 709319(ST3GAL2) 717792(ST3GAL4)
MMU: 
20442(St3gal1) 20443(St3gal4) 20444(St3gal2)
RNO: 
362924(St3gal1) 363040(St3gal4) 64442(St3gal2)
CFA: 
482050(ST3GAL1) 489714(ST3GAL2) 607094(ST3GAL4)
AML: 
100467054(ST3GAL1) 100470291(ST3GAL4) 100481599(ST3GAL2)
FCA: 
101087029(ST3GAL2) 101089330(ST3GAL1) 101089461(ST3GAL4)
BTA: 
282351(ST3GAL1) 404163(ST3GAL4) 444879(ST3GAL2)
SSC: 
100627772(ST3GAL2) 396602(ST3GAL4) 445537(ST3GAL1)
ECB: 
100054889(ST3GAL2) 100069007(ST3GAL1) 100072459
MDO: 
100011298(ST3GAL2) 100019589 100032599
SHR: 
100924982(ST3GAL1) 100925774(ST3GAL4) 100932061(ST3GAL2)
OAA: 
100074430 100077751 100081042 100089613
GGA: 
395139(ST3GAL2) 396140(ST3GAL1) 419718(ST3GAL4)
MGP: 
100540561 100542452 100550797
TGU: 
100224400(ST3GAL4) 100224643(ST3GAL1) 100231481(ST3GAL2)
ACS: 
100553436 100558500 100563798 100565594
XLA: 
100126621(st3gal2.2) 414465(st3gal2.1) 734512(st3gal4)
XTR: 
100329190(st3gal1) 100492150 394493(st3gal2.2) 403093(st3gal4)
DRE: 
445562(st3gal2) 504044(st3gal4)
TRU: 
445972(siat5) 446079(siat4) 780534(siat4c)
OLA: 
100049378(siat4) 100144348(siat5.2) 101157876
BFO: 
BRAFLDRAFT_92867
SPU: 
590209(st)
 » show all
Taxonomy
Reference
1  [PMID:438198]
  Authors
Rearick JI, Sadler JE, Paulson JC, Hill RL.
  Title
Enzymatic characterization of beta D-galactoside alpha2 leads to 3 sialyltransferase from porcine submaxillary gland.
  Journal
J. Biol. Chem. 254 (1979) 4444-51.
  Organism
Sus scofa [GN:ssc]
Reference
2  [PMID:438196]
  Authors
Sadler JE, Rearick JI, Paulson JC, Hill RL.
  Title
Purification to homogeneity of a beta-galactoside alpha2 leads to 3 sialyltransferase and partial purification of an alpha-N-acetylgalactosaminide alpha2 leads to 6 sialyltransferase from porcine submaxillary glands.
  Journal
J. Biol. Chem. 254 (1979) 4434-42.
  Organism
Sus scofa [GN:ssc]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
71124-51-1
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