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Entry
EC 2.5.1.128                Enzyme                                 

Name
N4-bis(aminopropyl)spermidine synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase [N4-bis(aminopropyl)spermidine synthesizing]
Reaction(IUBMB)
2 S-adenosyl 3-(methylthio)propylamine + spermidine = 2 S-methyl-5'-thioadenosine + N4-bis(aminopropyl)spermidine (overall reaction) [RN:R11154];
(1a) S-adenosyl 3-(methylthio)propylamine + spermidine = S-methyl-5'-thioadenosine + N4-aminopropylspermidine [RN:R11159];
(1b) S-adenosyl 3-(methylthio)propylamine + N4-aminopropylspermidine = S-methyl-5'-thioadenosine + N4-bis(aminopropyl)spermidine [RN:R11160]
Reaction(KEGG)
Substrate
S-adenosyl 3-(methylthio)propylamine [CPD:C01137];
spermidine [CPD:C00315];
N4-aminopropylspermidine [CPD:C21009]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
N4-bis(aminopropyl)spermidine [CPD:C21010];
N4-aminopropylspermidine [CPD:C21009]
Comment
The enzyme, characterized from the thermophilic archaeon Thermococcus kodakarensis, synthesizes the branched-chain polyamine N4-bis(aminopropyl)spermidine, which is required for cell growth at high-temperature. When spermine is used as substrate, the enzyme forms N4-aminopropylspermine.
History
EC 2.5.1.128 created 2014
Orthology
K07057  
N4-bis(aminopropyl)spermidine synthase
Genes
XNE: 
XNM: 
XDO: 
PSEC: 
PSOS: 
POS17_3685(Thein_2228)
BMYC: 
GGH: 
GEA: 
GEL: 
GSR: 
BBE: 
GYM: 
ANX: 
CBY: 
CBL: 
CBB: 
CBI: 
CBF: 
CBM: 
CBJ: 
CCB: 
CCE: 
DKU: 
CAD: 
TTE: 
TEX: 
THX: 
TPD: 
TIT: 
TMT: 
TBO: 
TWI: 
TKI: 
CHY: 
ADG: 
CSC: 
ATE: 
COB: 
CHD: 
COW: 
CKI: 
CKN: 
CLC: 
TOC: 
CPO: 
MHAD: 
SNA: 
TTH: 
TTJ: 
TTS: 
TTL: 
TPAR: 
TTR: 
TLI: 
AMO: 
RMR: 
RMG: 
AAE: 
HYA: 
HHO: 
HYS: 
HTH: 
HTE: 
TAL: 
TRD: 
SUL: 
SAF: 
PMX: 
TTK: 
TAM: 
DTE: 
TTA: 
CEX: 
TID: 
TOP: 
TCM: 
CTHI: 
WWE: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
PHO: 
PH0728(PH0728)
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
PYC: 
TKO: 
TON: 
TGA: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
TGY: 
THV: 
PPAC: 
ABI: 
ACF: 
LOKI: 
 » show all
Taxonomy
Reference
1  [PMID:24610711]
  Authors
Okada K, Hidese R, Fukuda W, Niitsu M, Takao K, Horai Y, Umezawa N, Higuchi T, Oshima T, Yoshikawa Y, Imanaka T, Fujiwara S
  Title
Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles.
  Journal
J. Bacteriol. 196 (2014) 1866-76.
  Sequence
[tko:TK1691]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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