KEGG   ENZYME: 2.5.1.27Help
Entry
EC 2.5.1.27                 Enzyme                                 

Name
adenylate dimethylallyltransferase;
cytokinin synthase (ambiguous);
isopentenyltransferase (ambiguous);
2-isopentenyl-diphosphate:AMP Delta2-isopentenyltransferase;
adenylate isopentenyltransferase (ambiguous);
IPT
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:AMP dimethylallyltransferase
Reaction(IUBMB)
dimethylallyl diphosphate + AMP = diphosphate + N6-(dimethylallyl)adenosine 5'-phosphate [RN:R04038]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
AMP [CPD:C00020]
Product
diphosphate [CPD:C00013];
N6-(dimethylallyl)adenosine 5'-phosphate [CPD:C04713]
Comment
Involved in the biosynthesis of cytokinins in plants. Some isoforms from the plant Arabidopsis thaliana are specific for AMP while others also have the activity of EC 2.5.1.112, adenylate dimethylallyltransferase (ADP/ATP-dependent).
History
EC 2.5.1.27 created 1984, modified 2002, modified 2013
Pathway
Zeatin biosynthesis
Reference
1  [PMID:499537]
  Authors
Chen CM, Melitz DK.
  Title
Cytokinin biosynthesis in a cell-free system from cytokinin-autotrophic tobacco tissue cultures.
  Journal
FEBS. Lett. 107 (1979) 15-20.
Reference
2  [PMID:11313355]
  Authors
Takei K, Sakakibara H, Sugiyama T
  Title
Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.
  Journal
J. Biol. Chem. 276 (2001) 26405-10.
  Sequence
[ath:AT1G68460]
Reference
3  [PMID:15381407]
  Authors
Sakano Y, Okada Y, Matsunaga A, Suwama T, Kaneko T, Ito K, Noguchi H, Abe I
  Title
Molecular cloning, expression, and characterization of adenylate isopentenyltransferase from hop (Humulus lupulus L.).
  Journal
Phytochemistry. 65 (2004) 2439-46.
  Sequence
[up:Q5GHF7]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
72840-95-0

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