heptaprenyl diphosphate synthase;
all-trans-heptaprenyl-diphosphate synthase;
heptaprenyl pyrophosphate synthase;
heptaprenyl pyrophosphate synthetase;
HepPP synthase;
HepPS;
heptaprenylpyrophosphate synthetase

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 4 isopentenyl units)

(2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate [RN:R09247]

R09247

(2E,6E)-farnesyl diphosphate [CPD:C00448];
isopentenyl diphosphate [CPD:C00129]

This enzyme catalyses the condensation reactions resulting in the formation of all-trans-heptaprenyl diphosphate, the isoprenoid side chain of ubiquinone-7 and menaquinone-7. The enzyme adds four isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.

1  [PMID:6768722]

Takahashi I, Ogura K, Seto S.

Heptaprenyl pyrophosphate synthetase from Bacillus subtilis.

J. Biol. Chem. 255 (1980) 4539-43.

Bacillus subtilis [GN:bsu]

2  [PMID:9748348]

Zhang YW, Koyama T, Marecak DM, Prestwich GD, Maki Y, Ogura K

Two subunits of heptaprenyl diphosphate synthase of Bacillus subtilis form a catalytically active complex.

Biochemistry. 37 (1998) 13411-20.

3  [PMID:10545188]

Zhang YW, Li XY, Sugawara H, Koyama T

Site-directed mutagenesis of the conserved residues in component I of Bacillus subtilis heptaprenyl diphosphate synthase.

Biochemistry. 38 (1999) 14638-43.

4  [PMID:17117872]

Suzuki T, Zhang YW, Koyama T, Sasaki DY, Kurihara K

Direct observation of substrate-enzyme complexation by surface forces measurement.

J. Am. Chem. Soc. 128 (2006) 15209-14.