KEGG   ENZYME: 2.5.1.63Help
Entry
EC 2.5.1.63                 Enzyme                                 

Name
adenosyl-fluoride synthase;
fluorinase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:fluoride adenosyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine [RN:R09637]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
fluoride [CPD:C00742]
Product
5'-deoxy-5'-fluoroadenosine [CPD:C19766];
L-methionine [CPD:C00073]
History
EC 2.5.1.63 created 2003
Reference
1  [PMID:11907567]
  Authors
O'Hagan D, Schaffrath C, Cobb SL, Hamilton JT, Murphy CD.
  Title
Biochemistry: biosynthesis of an organofluorine molecule.
  Journal
Nature. 416 (2002) 279.
Reference
2  [PMID:14765200]
  Authors
Dong C, Huang F, Deng H, Schaffrath C, Spencer JB, O'Hagan D, Naismith JH.
  Title
Crystal structure and mechanism of a bacterial fluorinating enzyme.
  Journal
Nature. 427 (2004) 561-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
438583-16-5

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