KEGG   ENZYME: 2.5.1.65Help
Entry
EC 2.5.1.65                 Enzyme                                 

Name
O-phosphoserine sulfhydrylase;
O-phosphoserine(thiol)-lyase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
Reaction(IUBMB)
O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate [RN:R07274]
Reaction(KEGG)
R07274;
(other) R00897
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Substrate
O-phospho-L-serine [CPD:C01005];
hydrogen sulfide [CPD:C00283]
Product
L-cysteine [CPD:C00097];
phosphate [CPD:C00009]
Comment
A pyridoxal-phosphate protein. The enzyme from Aeropyrum pernix acts on both O-phospho-L-serine and O3-acetyl-L-serine, in contrast with EC 2.5.1.47, cysteine synthase, which acts only on O3-acetyl-L-serine.
History
EC 2.5.1.65 created 2004
Pathway
Cysteine and methionine metabolism
Sulfur metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K10150  
cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
Genes
APE: 
APE_1586(cysK)
DMU: 
DFD: 
TAG: 
IAG: 
THG: 
HBU: 
PFM: 
PIS: 
TPE: 
ASC: 
CLG: 
 » show all
Taxonomy
Reference
1  [PMID:12965218]
  Authors
Mino K, Ishikawa K.
  Title
A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
FEBS. Lett. 551 (2003) 133-8.
Reference
2  [PMID:12644499]
  Authors
Mino K, Ishikawa K.
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J. Bacteriol. 185 (2003) 2277-84.
  Sequence
[ape:APE_1586]
Reference
3  [PMID:12554945]
  Authors
Mino K, Oda Y, Ataka M, Ishikawa K.
  Title
Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
Acta. Crystallogr. D. Biol. Crystallogr. 59 (2003) 338-40.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
1071505-11-7

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