KEGG   ENZYME: 2.5.1.76Help
Entry
EC 2.5.1.76                 Enzyme                                 
Name
cysteate synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
sulfite:O-phospho-L-serine sulfotransferase (phosphate-hydrolysing, L-cysteate-forming)
Reaction(IUBMB)
O-phospho-L-serine + sulfite = L-cysteate + phosphate [RN:R09530]
Reaction(KEGG)
Substrate
O-phospho-L-serine [CPD:C01005];
sulfite [CPD:C00094]
Product
L-cysteate [CPD:C00506];
phosphate [CPD:C00009]
Comment
A pyridoxal-phosphate protein. It is highly specific for O-phospho-L-serine and sulfite. The reaction proceeds through a dehydroalanine (2-aminoacrylic acid) intermediate. The enzyme from Methanosarcina acetivorans is evolutionarily related to threonine synthase (EC 4.2.3.1), but the reaction is more similar to that of O-phosphoserine sulfhydrylase (EC 2.5.1.65).
Orthology
K15527  
cysteate synthase
Genes
OSP: 
MAC: 
MA3297(thrC)
MBA: 
MMA: 
MBU: 
MMH: 
MZH: 
MTP: 
MCJ: 
MHU: 
MLA: 
Mlab_0503
MEM: 
Memar_0111
MPI: 
Mpet_0280
MBN: 
Mboo_2116
MPL: 
Mpal_2734
MPD: 
MCP_1992
RCI: 
LRC440(thrC-2)
FPL: 
Ferp_0996
 » show all
Taxonomy
Reference
1  [PMID:19761441]
  Authors
Graham DE, Taylor SM, Wolf RZ, Namboori SC
  Title
Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase.
  Journal
Biochem. J. 424 (2009) 467-78.
  Organism
Methanosarcina acetivorans [GN:mac]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system