KEGG   ENZYME: 2.5.1.76Help
Entry
EC 2.5.1.76                 Enzyme                                 

Name
cysteate synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
sulfite:O-phospho-L-serine sulfotransferase (phosphate-hydrolysing, L-cysteate-forming)
Reaction(IUBMB)
O-phospho-L-serine + sulfite = L-cysteate + phosphate [RN:R09530]
Reaction(KEGG)
Substrate
O-phospho-L-serine [CPD:C01005];
sulfite [CPD:C00094]
Product
L-cysteate [CPD:C00506];
phosphate [CPD:C00009]
Comment
A pyridoxal-phosphate protein. It is highly specific for O-phospho-L-serine and sulfite. The reaction proceeds through a dehydroalanine (2-aminoacrylic acid) intermediate. The enzyme from Methanosarcina acetivorans is evolutionarily related to threonine synthase (EC 4.2.3.1), but the reaction is more similar to that of O-phosphoserine sulfhydrylase (EC 2.5.1.65).
History
EC 2.5.1.76 created 2009
Orthology
K15527  
cysteate synthase
Genes
SBH: 
SBI_01127(thrC1)
SESP: 
BN6_58880(sam27)
BACC: 
OSP: 
AFD: 
RBC: 
DOI: 
MAC: 
MA_3297(thrC)
MBA: 
MBY: 
MBW: 
MBAR: 
MMA: 
MMAZ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
BN140_0055(thrC1)
MPI: 
MBN: 
MPL: 
MPD: 
MEZ: 
RCI: 
LRC440(thrC-2)
FPL: 
GAC: 
GAH: 
MAX: 
MER: 
 » show all
Taxonomy
Reference
1  [PMID:19761441]
  Authors
Graham DE, Taylor SM, Wolf RZ, Namboori SC
  Title
Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase.
  Journal
Biochem. J. 424 (2009) 467-78.
  Sequence
[mac:MA_3297]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

  All links  
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