KEGG   ENZYME: 2.5.1.84Help
Entry
EC 2.5.1.84                 Enzyme                                 

Name
all-trans-nonaprenyl diphosphate synthase [geranyl-diphosphate specific];
nonaprenyl diphosphate synthase (ambiguous);
solanesyl diphosphate synthase (ambiguous);
SolPP synthase (ambiguous);
SPP-synthase (ambiguous);
SPP synthase (ambiguous);
solanesyl-diphosphate synthase (ambiguous);
OsSPS2
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 7 isopentenyl units)
Reaction(IUBMB)
geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate [RN:R09250]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-nonaprenyl diphosphate [CPD:C04145]
Comment
(2E,6E)-Farnesyl diphosphate and geranylgeranyl diphosphate are less effective as substrates than geranyl diphosphate. The enzyme is involved in the synthesis of the side chain of menaquinone-9 [1]. In Oryza sativa the enzyme SPS2 is involved in providing solanesyl diphosphate for plastoquinone-9 formation [3].
History
EC 2.5.1.84 created 1972 as EC 2.5.1.11, part transferred 2010 to EC 2.5.1.84
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05356  all-trans-nonaprenyl-diphosphate synthase
Genes
ATH: AT1G17050(SPS2) AT1G78510(SPS1)
ALY: ARALYDRAFT_494049 ARALYDRAFT_895751
CSAT: 104702634 104713531 104740392 104751747 104756029 104775809
EUS: EUTSA_v10007715mg EUTSA_v10018616mg
BRP: 103832329 103872491
BNA: 106346730 106354554 106354696 106365558
BOE: 106301071 106343305
THJ: 104810419 104812299 104813301 104813987 104822586
CPAP: 110811666
CIT: 102612772
TCC: 18594463
DZI: 111298875
VRA: 106762491
VAR: 108334430
CCAJ: 109790225
CAM: 101502183
ADU: 107459857
AIP: 107613812
LJA: Lj0g3v0072399.1(Lj0g3v0072399.1) Lj0g3v0072399.2(Lj0g3v0072399.2)
FVE: 101297041
PPER: 18778932
PMUM: 103325805
PAVI: 110772576
ZJU: 107414345
CSV: 101214140
CMO: 103492962
MCHA: 111012845
RCU: 8258714
JCU: 105641085
JRE: 108994345
VVI: 100246988
SLY: 101253007(SppS)
SPEN: 107026209
SOT: 102593674
CANN: 107878554
NSY: 104243529
NTO: 104101158
BVG: 104899063
SOE: 110783766
DOSA: Os05t0582300-01(Os05g0582300)
ATS: 109748254(LOC109748254)
SBI: 8155346
PDA: 103712684
MUS: 103989203
DCT: 110112294
AOF: 109842749
ATR: 18430924
OLU: OSTLU_51700(clpR2)
APRO: F751_0189
SMIN: v1.2.008416.t1(symbB.v1.2.008416.t1)
SYN: slr0611(sds)
SYZ: MYO_110(sds)
SYY: SYNGTS_0001(sds)
SYT: SYNGTI_0001(sds)
SYS: SYNPCCN_0001(sds)
SYQ: SYNPCCP_0001(sds)
SYJ: D082_04480(sds)
SYW: SYNW1011(sds)
SYC: syc1741_c(sds)
SYG: sync_1551
SYR: SynRCC307_1159(preA)
SYX: SynWH7803_1038(preA)
SYP: SYNPCC7002_A0580(sdsA)
CYA: CYA_2276(sds)
CYB: CYB_0451(sds)
SYNR: KR49_03240
SYND: KR52_10950
SYNW: SynWH8103_01143(sds)
TEL: tlr1757(sds)
THN: NK55_05445(sdsA)
CYI: CBM981_0715(preA)
LET: O77CONTIG1_01361(hepT)
HHG: XM38_031750(preA)
PMA: Pro_1042(crtE)
PMM: PMM0618(sds)
PMT: PMT_0392
PMB: A9601_06741(sds)
PMC: P9515_06831(sds)
PMF: P9303_18951(sds)
PMG: P9301_06441(sds)
PMH: P9215_07001(sds)
PMJ: P9211_10311(sds)
PME: NATL1_06761(sds)
PRC: EW14_0663
PRM: EW15_0718
AMR: AM1_4909(sds)
MAR: MAE_00010(sds)
MPK: VL20_2046
CYL: AA637_04100(sds)
CYT: cce_2465(sds)
TER: Tery_0157
ARP: NIES39_N00440(sds)
GVI: gvip084(sds)
GLJ: GKIL_2127(sds)
ANA: alr0096(sds)
NOE: CLI64_12930(sds)
AVA: Ava_1469
NAZ: Aazo_0858
ANB: ANA_C12807(sds)
CALH: IJ00_17620
CTHE: Chro_0646
CEO: ETSB_0422(sds)
 » show all
Taxonomy
Reference
1  [PMID:911777]
  Authors
Sagami H, Ogura K, Seto S
  Title
Solanesyl pyrophosphate synthetase from Micrococcus lysodeikticus.
  Journal
Biochemistry. 16 (1977) 4616-22.
Reference
2  [PMID:7447947]
  Authors
Fujii H, Sagami H, Koyama T, Ogura K, Seto S, Baba T, Allen CM.
  Title
Variable product specificity of solanesyl pyrophosphate synthetase.
  Journal
Biochem. Biophys. Res. Commun. 96 (1980) 1648-53.
Reference
3  [PMID:20421194]
  Authors
Ohara K, Sasaki K, Yazaki K
  Title
Two solanesyl diphosphate synthases with different subcellular localizations and  their respective physiological roles in Oryza sativa.
  Journal
J. Exp. Bot. 61 (2010) 2683-92.
  Sequence
[osa:4341844]
Reference
4  [PMID:1748647]
  Authors
Ohnuma S, Koyama T, Ogura K
  Title
Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase.
  Journal
J. Biol. Chem. 266 (1991) 23706-13.
Reference
5  [PMID:1429508]
  Authors
Gotoh T, Koyama T, Ogura K
  Title
Farnesyl diphosphate synthase and solanesyl diphosphate synthase reactions of diphosphate-modified allylic analogs: the significance of the diphosphate linkage involved in the allylic substrates for prenyltransferase.
  Journal
J. Biochem. 112 (1992) 20-7.
Reference
6  [PMID:8226825]
  Authors
Teclebrhan H, Olsson J, Swiezewska E, Dallner G
  Title
Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes.
  Journal
J. Biol. Chem. 268 (1993) 23081-6.
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.84
IUBMB Enzyme Nomenclature: 2.5.1.84
ExPASy - ENZYME nomenclature database: 2.5.1.84
BRENDA, the Enzyme Database: 2.5.1.84

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