KEGG   ENZYME: 2.5.1.84Help
Entry
EC 2.5.1.84                 Enzyme                                 

Name
all-trans-nonaprenyl-diphosphate synthase [geranyl-diphosphate specific];
nonaprenyl diphosphate synthase (ambiguous);
solanesyl diphosphate synthase (ambiguous);
SolPP synthase (ambiguous);
SPP-synthase (ambiguous);
SPP synthase (ambiguous);
solanesyl-diphosphate synthase (ambiguous);
OsSPS2
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 7 isopentenyl units)
Reaction(IUBMB)
geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate [RN:R09250]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-nonaprenyl diphosphate [CPD:C04145]
Comment
(2E,6E)-Farnesyl diphosphate and geranylgeranyl diphosphate are less effective as substrates than geranyl diphosphate. The enzyme is involved in the synthesis of the side chain of menaquinone-9 [1]. In Oryza sativa the enzyme SPS2 is involved in providing solanesyl diphosphate for plastoquinone-9 formation [3].
History
EC 2.5.1.84 created 1972 as EC 2.5.1.11, part transferred 2010 to EC 2.5.1.84
Pathway
Terpenoid backbone biosynthesis
Biosynthesis of secondary metabolites
Orthology
K05356  
all-trans-nonaprenyl-diphosphate synthase
Genes
ATH: 
AT1G17050(SPS2) AT1G78510(SPS1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0072399.1(Lj0g3v0072399.1) Lj0g3v0072399.2(Lj0g3v0072399.2)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
VVI: 
SLY: 
101253007(SppS)
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
107276142(OJ1651_G11.10) 4351957
DOSA: 
Os05t0582300-01(Os05g0582300)
OBR: 
BDI: 
SBI: 
SORBI_0011s005450(SORBIDRAFT_0011s005450) SORBI_09g029730(SORBIDRAFT_09g029730)
ZMA: 
100191875(GRMZM2G112728) 100282721(GRMZM2G163809) 103653367
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
SMIN: 
v1.2.008416.t1(symbB.v1.2.008416.t1)
SYN: 
slr0611(sds)
SYZ: 
MYO_110(sds)
SYY: 
SYT: 
SYS: 
SYQ: 
SYJ: 
SYW: 
SYC: 
SYF: 
SYD: 
SYE: 
SYG: 
SYR: 
SYX: 
SYP: 
CYA: 
CYB: 
SYNE: 
SYNP: 
SYNK: 
SYNR: 
SYND: 
SYU: 
SYH: 
TEL: 
tlr1757(sds)
THN: 
CGC: 
DSL: 
CMP: 
LEP: 
LEN: 
LET: 
PSEU: 
PMA: 
Pro_1042(crtE)
PMM: 
PMM0618(sds)
PMT: 
PMN: 
PMI: 
PMB: 
PMC: 
PMF: 
PMG: 
PMH: 
PMJ: 
PME: 
PRC: 
PRM: 
AMR: 
MAR: 
MPK: 
CAN: 
CSN: 
HAO: 
CYU: 
GLP: 
GEN: 
GEE: 
CYT: 
CYP: 
CYC: 
CYN: 
CYH: 
CYJ: 
TER: 
MIC: 
ARP: 
GEI: 
OAC: 
ONI: 
MPRO: 
CEP: 
GVI: 
gvip084(sds)
GLJ: 
ANA: 
alr0096(sds)
NPU: 
NOS: 
NOP: 
NON: 
AVA: 
ANB: 
ACY: 
AWA: 
NAZ: 
CSG: 
CALO: 
CALT: 
CALH: 
RIV: 
FIS: 
CTHE: 
PLP: 
SCS: 
CEO: 
 » show all
Taxonomy
Reference
1  [PMID:911777]
  Authors
Sagami H, Ogura K, Seto S
  Title
Solanesyl pyrophosphate synthetase from Micrococcus lysodeikticus.
  Journal
Biochemistry. 16 (1977) 4616-22.
Reference
2  [PMID:7447947]
  Authors
Fujii H, Sagami H, Koyama T, Ogura K, Seto S, Baba T, Allen CM.
  Title
Variable product specificity of solanesyl pyrophosphate synthetase.
  Journal
Biochem. Biophys. Res. Commun. 96 (1980) 1648-53.
Reference
3  [PMID:20421194]
  Authors
Ohara K, Sasaki K, Yazaki K
  Title
Two solanesyl diphosphate synthases with different subcellular localizations and  their respective physiological roles in Oryza sativa.
  Journal
J. Exp. Bot. 61 (2010) 2683-92.
  Sequence
[osa:4341844]
Reference
4  [PMID:1748647]
  Authors
Ohnuma S, Koyama T, Ogura K
  Title
Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase.
  Journal
J. Biol. Chem. 266 (1991) 23706-13.
Reference
5  [PMID:1429508]
  Authors
Gotoh T, Koyama T, Ogura K
  Title
Farnesyl diphosphate synthase and solanesyl diphosphate synthase reactions of diphosphate-modified allylic analogs: the significance of the diphosphate linkage involved in the allylic substrates for prenyltransferase.
  Journal
J. Biochem. 112 (1992) 20-7.
Reference
6  [PMID:8226825]
  Authors
Teclebrhan H, Olsson J, Swiezewska E, Dallner G
  Title
Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes.
  Journal
J. Biol. Chem. 268 (1993) 23081-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system