KEGG   ENZYME: 2.5.1.85Help
Entry
EC 2.5.1.85                 Enzyme                                 

Name
all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific];
nonaprenyl diphosphate synthase (ambiguous);
solanesyl diphosphate synthase (ambiguous);
At-SPS2;
At-SPS1;
SPS1;
SPS2
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 5 isopentenyl units)
Reaction(IUBMB)
geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate [RN:R09251]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-nonaprenyl diphosphate [CPD:C04145]
Comment
Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate [1]. The plant Arabidopsis thaliana has two different enzymes that catalyse this reaction. SPS1 contributes to the biosynthesis of the ubiquinone side-chain while SPS2 supplies the precursor of the plastoquinone side-chains [2].
History
EC 2.5.1.85 created 1972 as EC 2.5.1.11, part transferred 2010 to EC 2.5.1.85
Pathway
Terpenoid backbone biosynthesis
Biosynthesis of secondary metabolites
Orthology
K05356  
all-trans-nonaprenyl-diphosphate synthase
Genes
ATH: 
AT1G17050(SPS2) AT1G78510(SPS1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0072399.1(Lj0g3v0072399.1) Lj0g3v0072399.2(Lj0g3v0072399.2)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
VVI: 
SLY: 
101253007(SppS)
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os05t0582300-01(Os05g0582300)
OBR: 
BDI: 
SBI: 
SORBI_0011s005450(SORBIDRAFT_0011s005450) SORBI_09g029730(SORBIDRAFT_09g029730)
ZMA: 
100191875(GRMZM2G112728) 100282721(GRMZM2G163809) 103653367
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
SMIN: 
v1.2.008416.t1(symbB.v1.2.008416.t1)
SYN: 
slr0611(sds)
SYZ: 
MYO_110(sds)
SYY: 
SYT: 
SYS: 
SYQ: 
SYJ: 
SYW: 
SYC: 
SYF: 
SYD: 
SYE: 
SYG: 
SYR: 
SYX: 
SYP: 
CYA: 
CYB: 
SYNE: 
SYNP: 
SYNK: 
SYNR: 
SYND: 
SYU: 
SYH: 
TEL: 
tlr1757(sds)
THN: 
CGC: 
DSL: 
CMP: 
LEP: 
LEN: 
LET: 
PSEU: 
PMA: 
Pro_1042(crtE)
PMM: 
PMM0618(sds)
PMT: 
PMN: 
PMI: 
PMB: 
PMC: 
PMF: 
PMG: 
PMH: 
PMJ: 
PME: 
PRC: 
PRM: 
AMR: 
MAR: 
MPK: 
CAN: 
CSN: 
HAO: 
CYU: 
GLP: 
GEN: 
GEE: 
CYT: 
CYP: 
CYC: 
CYN: 
CYH: 
CYJ: 
TER: 
MIC: 
ARP: 
GEI: 
OAC: 
ONI: 
CEP: 
GVI: 
gvip084(sds)
GLJ: 
ANA: 
alr0096(sds)
NPU: 
NOS: 
NOP: 
NON: 
AVA: 
ANB: 
ACY: 
AWA: 
NAZ: 
CSG: 
CALO: 
CALT: 
CALH: 
RIV: 
FIS: 
CTHE: 
PLP: 
SCS: 
CEO: 
 » show all
Taxonomy
Reference
1  [PMID:12437513]
  Authors
Hirooka K, Bamba T, Fukusaki E, Kobayashi A
  Title
Cloning and kinetic characterization of Arabidopsis thaliana solanesyl diphosphate synthase.
  Journal
Biochem. J. 370 (2003) 679-86.
  Sequence
[ath:AT1G78510]
Reference
2  [PMID:15784989]
  Authors
Hirooka K, Izumi Y, An CI, Nakazawa Y, Fukusaki E, Kobayashi A
  Title
Functional analysis of two solanesyl diphosphate synthases from Arabidopsis thaliana.
  Journal
Biosci. Biotechnol. Biochem. 69 (2005) 592-601.
  Sequence
[ath:AT1G17050]
Reference
3  [PMID:15653808]
  Authors
Jun L, Saiki R, Tatsumi K, Nakagawa T, Kawamukai M
  Title
Identification and subcellular localization of two solanesyl diphosphate synthases from Arabidopsis thaliana.
  Journal
Plant. Cell. Physiol. 45 (2004) 1882-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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