KEGG   ENZYME: 2.5.1.92Help
Entry
EC 2.5.1.92                 Enzyme                                 

Name
(2Z,6Z)-farnesyl diphosphate synthase;
cis,cis-farnesyl diphosphate synthase;
Z,Z-FPP synthase;
zFPS;
Z,Z-farnesyl pyrophosphate synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 2 isopentenyl units)
Reaction(IUBMB)
dimethylallyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + (2Z,6Z)-farnesyl diphosphate [RN:R09633]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
isopentenyl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
(2Z,6Z)-farnesyl diphosphate [CPD:C19760]
Comment
This enzyme, originally characterized from wild tomato, specifically forms (2Z,6Z)-farnesyl diphosphate via neryl diphosphate and isopentenyl diphosphate. In wild tomato it is involved in the biosynthesis of several sesquiterpenes. See also EC 2.5.1.68 [(2Z,6E)-farnesyl diphosphate synthase] and EC 2.5.1.10 [(2E,6E)-farnesyl diphosphate synthase].
History
EC 2.5.1.92 created 2010, modified 2011
Pathway
Terpenoid backbone biosynthesis
Orthology
K15887  
(2Z,6Z)-farnesyl diphosphate synthase
Reference
1  [PMID:19155349]
  Authors
Sallaud C, Rontein D, Onillon S, Jabes F, Duffe P, Giacalone C, Thoraval S, Escoffier C, Herbette G, Leonhardt N, Causse M, Tissier A
  Title
A novel pathway for sesquiterpene biosynthesis from Z,Z-farnesyl pyrophosphate in the wild tomato Solanum habrochaites.
  Journal
Plant. Cell. 21 (2009) 301-17.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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