| Entry |
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| Name |
(S)-3-amino-2-methylpropionate transaminase;
L-3-aminoisobutyrate transaminase;
beta-aminobutyric transaminase;
L-3-aminoisobutyric aminotransferase;
beta-aminoisobutyrate-alpha-ketoglutarate transaminase
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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| Sysname |
(S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase
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| Reaction(IUBMB) |
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate
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| Reaction(KEGG) |
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| Substrate |
(S)-3-amino-2-methylpropanoate [CPD: C03284];
2-oxoglutarate [CPD: C00026]
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| Product |
2-methyl-3-oxopropanoate [CPD: C00349];
L-glutamate [CPD: C00025]
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| Comment |
Also acts on beta-alanine and other omega-amino acids having carbon chains between 2 and 5. The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.40, (R)-3-amino-2-methylpropionate---pyruvate transaminase, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.
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| Pathway |
| Valine, leucine and isoleucine degradation |
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| Orthology |
| 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase | | 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | API: | | PHU: | | ISC: | | CEL: | | CBR: | | BMY: | | NVE: | | HMG: | | TAD: | | AQU: | | OLU: | | OTA: | | CME: | | SCE: | | AGO: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | SPO: | | CNE: | | CNB: | | CGI: | | UMA: | | PGR: | | NGR: | | DDI: | | DPP: | | PIF: | | ECO: | | ECJ: | | ECD: | | EBW: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBE: | | ECOA: | | EFE: | | EBT: | | STY: | | STT: | | SEX: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SEG: | | SET: | | SES: | | SBG: | | SFL: | | SFX: | | SFV: | | SFE: | | SSN: | | SSJ: | | EBI: | | EAE: | | ESA: | | CTU: | | KPN: | | KPU: | | KPM: | | KPE: | | KPO: | | KVA: | | CKO: | | PAM: | | PVA: | | EBF: | | VPA: | | VEJ: | | PST: | | PSB: | | PSP: | | PFS: | | CJA: | | PAR: | | PCR: | | PRW: | | SON: | | SDN: | | SFR: | | SAZ: | | SBL: | | SBM: | | SBN: | | SBP: | | SLO: | | SPC: | | SSE: | | SPL: | | SHE: | | SHM: | | SHN: | | SHW: | | SHL: | | SWD: | | SWP: | | CPS: | | MAQ: | | PIN: | | LPN: | | LPF: | | LPP: | | LPC: | | LPA: | | CSA: | | HEL: | | MMW: | | AHA: | | ASA: | | TAU: | | REU: | | CTI: | | BMU: | | BMJ: | | BXE: | | BPE: | | BPA: | | BBR: | | AXY: | | RFR: | | POL: | | PNA: | | VAP: | | LCH: | | TMZ: | | GUR: | | GEB: | | DDE: | | DMA: | | DBA: | | DAT: | | DTO: | | SUR: | | SCL: | | HOH: | | DTI: | | SFU: | | BRA: | | BBT: | | RPA: | | RPB: | | RPC: | | RPT: | | XAU: | | PZU: | | JAN: | | RDE: | | NAR: | | SWI: | | ACR: | | GDI: | | GDJ: | | APT: | | AZL: | | PBR: | | PGV: | | BSU: | | BSR: | | BSL: | | BSS: | | BST: | | BSN: | | BSQ: | | BSUB: | | BLI: | | BLD: | | BAO: | | BAY: | | BAQ: | | BYA: | | BAMP: | | BAZ: | | BQL: | | BXH: | | BQY: | | BAE: | | BHA: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BCY: | | BTK: | | BTL: | | BTB: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BWE: | | BPU: | | BMQ: | | BMD: | | BMH: | | BCK: | | BAG: | | BJS: | | GTH: | | GYC: | | GYA: | | GCT: | | GMC: | | AFL: | | SSP: | | HHD: | | BBE: | | PMS: | | PMQ: | | PMW: | | AAC: | | BTS: | | CAC: | | CAE: | | CAY: | | CBE: | | CKL: | | CKR: | | CLJ: | | AMT: | | STH: | | DKU: | | PTH: | | DOR: | | DAI: | | EHA: | | TMR: | | SAY: | | HOR: | | MED: | | MTU: | | MTV: | | MTC: | | MRA: | | MTF: | | MTB: | | MTK: | | MTZ: | | MTG: | | MTI: | | MTE: | | MTL: | | MTO: | | MTD: | | MBO: | | MBB: | | MBT: | | MBM: | | MAF: | | MCE: | | MCV: | | MCX: | | MCZ: | | MLE: | | MLB: | | MPA: | | MAV: | | MIT: | | MIR: | | MIA: | | MID: | | MSM: | | MSG: | | MSA: | | MUL: | | MVA: | | MGI: | | MSP: | | MAB: | | MMV: | | MMC: | | MKM: | | MJL: | | MJD: | | MMI: | | MRH: | | MMM: | | MCB: | | MLI: | | ASD: | | CGL: | | CGB: | | CGT: | | CAR: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | TPR: | | SRT: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SVE: | | KSK: | | TWH: | | TWS: | | LXX: | | CMI: | | CMS: | | MTS: | | ART: | | AAU: | | ACH: | | AAI: | | APN: | | ARR: | | RSA: | | KRH: | | MLU: | | RDN: | | ICA: | | PFR: | | MPH: | | NCA: | | TFU: | | NDA: | | NAL: | | SRO: | | FRA: | | FRE: | | FRI: | | FAL: | | ACE: | | NML: | | GOB: | | KRA: | | SEN: | | TBI: | | AMD: | | AMN: | | AMM: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | CAI: | | BDE: | | RXY: | | LBI: | | LBF: | | ABA: | | HHY: | | GFO: | | IPO: | | RRS: | | RCA: | | CAU: | | CAG: | | CHL: | | TRO: | | TRA: | | TSC: | | MRB: | | MSV: | | HTU: | | HVO: | | ABI: | |
» show all
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| Reference |
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| Authors |
Kakimoto Y, Kanazawa A, Taniguchi K, Sano I. |
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| Title |
Beta-aminoisobutyrate-alpha-ketoglutarate transaminase in relation to beta-aminoisobutyric aciduria. |
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| Journal |
Biochim. Biophys. Acta. 156 (1968) 374-80. |
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| Organism |
Homo sapiens [GN: hsa], Sus scofa [GN: ssc] |
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| Reference |
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| Authors |
Tamaki N, Sakata SF, Matsuda K. |
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| Title |
Purification, properties, and sequencing of aminoisobutyrate aminotransferases from rat liver. |
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| Journal |
Methods. Enzymol. 324 (2000) 376-89. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9031-95-2 |
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