KEGG   ENZYME: 2.6.1.77Help
Entry
EC 2.6.1.77                 Enzyme                                 
Name
taurine---pyruvate aminotransferase;
Tpa
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
taurine:pyruvate aminotransferase
Reaction(IUBMB)
taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde [RN:R05652]
Reaction(KEGG)
Substrate
taurine [CPD:C00245];
pyruvate [CPD:C00022]
Product
L-alanine [CPD:C00041];
2-sulfoacetaldehyde [CPD:C00593]
Comment
The enzyme from Bilophila wadsworthia requires pyridoxal 5'-phosphate as a cofactor, is reversible, and catalyses the first step of anaerobic taurine degradation. Hypotaurine (i.e. 2-aminoethanesulfinate) and beta-alanine are also significant donors of an amino group. Unlike, EC 2.6.1.55, taurine---2-oxoglutarate transaminase, 2-oxoglutarate is not an acceptor of amino groups.
Pathway
Taurine and hypotaurine metabolism
Metabolic pathways
Orthology
K03851  
taurine-pyruvate aminotransferase
Genes
PIN: 
BPE: 
BPA: 
BBR: 
DVM: 
DDS: 
DPS: 
SIL: 
SPO0673(tpa)
SIT: 
RSP: 
RSP_0943(yhxA)
RSH: 
Rsph17029_2602
RSQ: 
Rsph17025_2972
RSK: 
RSKD131_2333
RCP: 
RCAP_rcc02240(tpa)
RDE: 
RD1_0981(tpa)
PDE: 
Pden_4273
DSH: 
Dshi_2042(tpa)
KVU: 
EIO_1453
 » show all
Taxonomy
Reference
1  [PMID:11082195]
  Authors
Laue H, Cook AM.
  Title
Biochemical and molecular characterization of taurine:pyruvate aminotransferase from the anaerobe Bilophila wadsworthia.
  Journal
Eur. J. Biochem. 267 (2000) 6841-8.
  Organism
Bilophila wadsworthia
Reference
2  [PMID:12471498]
  Authors
Cook AM, Denger K.
  Title
Dissimilation of the C2 sulfonates.
  Journal
Arch. Microbiol. 179 (2002) 1-6.
  Organism
Pseudomonas aeruginosa, Desulfonispora thiosulfatigenes, Bilophila wadsworthia, Alcaligenes defragrans
Reference
3  [PMID:11728723]
  Authors
Masepohl B, Fuhrer F, Klipp W.
  Title
Genetic analysis of a Rhodobacter capsulatus gene region involved in utilization of taurine as a sulfur source.
  Journal
FEMS. Microbiol. Lett. 205 (2001) 105-11.
  Organism
Rhodobacter capsulatus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
51901-18-9
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