| Entry |
|
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| Name |
hexokinase;
hexokinase type IV glucokinase;
hexokinase D;
hexokinase type IV;
hexokinase (phosphorylating);
ATP-dependent hexokinase;
glucose ATP phosphotransferase |
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
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| Sysname |
ATP:D-hexose 6-phosphotransferase |
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| Reaction(IUBMB) |
ATP + D-hexose = ADP + D-hexose 6-phosphate [RN:R02848] |
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| Reaction(KEGG) |
R02848 > R00299 R00760 R00867 R01326 R01600 R01786 R01961 R02865
R03920;
(other) R00725 R00876 R01139 R01140 R01327 R01330 R01964 R01965
R02849 R02850 R02867 R02868
 |
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| Substrate |
ATP [CPD:C00002];
D-hexose [CPD:C00738] |
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| Product |
ADP [CPD:C00008];
D-hexose 6-phosphate [CPD:C02965] |
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| Comment |
D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act
as acceptors; ITP and dATP can act as donors. The liver isoenzyme
has sometimes been called glucokinase. |
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| Pathway |
ec00010 Glycolysis / Gluconeogenesis
ec00051 Fructose and mannose metabolism
ec00052 Galactose metabolism
ec00500 Starch and sucrose metabolism
ec00520 Amino sugar and nucleotide sugar metabolism
ec00521 Streptomycin biosynthesis
ec00524 Butirosin and neomycin biosynthesis
ec01100 Metabolic pathways
ec01110 Biosynthesis of secondary metabolites |
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| Orthology |
K00844 hexokinase |
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| Genes |
HSA: 3098(HK1) 3099(HK2) 3101(HK3)
PTR: 450505(HK1) 462298(HK3) 741291(HK2)
MCC: 698120(HK3) 710479(HK2) 711922(HK1)
MMU: 15275(Hk1) 15277(Hk2) 212032(Hk3)
RNO: 25058(Hk1) 25059(Hk2) 25060(Hk3)
CFA: 475781(HK2) 479234(HK1) 489096(HK3)
BTA: 280817(HK1) 281771(HK1) 788926(HK2)
SSC: 100152344 494561(HK2)
ECB: 100009677(HK2) 100068725 100072687
MDO: 100031311 100031793 100032849
GGA: 373889(HK1) 374044(HK2)
TGU: 100226456
XLA: 394323(hk1)
XTR: 100124752(hk1)
DRE: 406339(hk2) 406791(hk1)
BFO: BRAFLDRAFT_126138
CIN: 100180240
SPU: 594105
DME: Dmel_CG3001(Hex-A) Dmel_CG32849(Hex-t2) Dmel_CG33102(Hex-t1)
Dmel_CG8094(Hex-C)
DPO: Dpse_GA15574 Dpse_GA17282 Dpse_GA20820
DAN: Dana_GF12622 Dana_GF20727 Dana_GF20735 Dana_GF22320
DER: Dere_GG11476 Dere_GG11478 Dere_GG18317 Dere_GG22367
DPE: Dper_GL11018 Dper_GL15877 Dper_GL21847 Dper_GL21996
DSE: Dsec_GM10320 Dsec_GM10321 Dsec_GM11376 Dsec_GM20151
DSI: Dsim_GD21281(Dsim_Hex-t1) Dsim_GD21282(Dsim_Hex-t2)
Dsim_GD25630
DWI: Dwil_GK13969 Dwil_GK16160 Dwil_GK18967 Dwil_GK21542
DYA: Dyak_GE12255(Dyak_Hex-C) Dyak_GE17799(Dyak_Hex-A)
Dyak_GE23668(Dyak_Hex-t1) Dyak_GE23669(Dyak_Hex-t2)
DGR: Dgri_GH12375 Dgri_GH19418 Dgri_GH19419 Dgri_GH21465
DMO: Dmoj_GI14754 Dmoj_GI19942 Dmoj_GI22622 Dmoj_GI22624
DVI: Dvir_GJ15111 Dvir_GJ19157 Dvir_GJ23869 Dvir_GJ23870
AGA: AgaP_AGAP011208
AAG: AaeL_AAEL009387
CQU: CpipJ_CPIJ008049
AME: 551005(GB19387)
NVI: 100121683(NV10713)
TCA: 657694 659227
API: 100169524(ACYPI010135)
PHU: Phum_PHUM419880
ISC: IscW_ISCW012387
CEL: F14B4.2(hexokinase)
CBR: CBG19465
BMY: Bm1_41805
SMM: Smp_043030
NVE: NEMVE_v1g229061
TAD: TRIADDRAFT_50939
ATH: AT1G47840(HXK3) AT2G19860(HXK2) AT4G29130(HXK1) AT4G37840(HKL3)
POP: POPTR_764893 POPTR_797614 POPTR_815248 POPTR_818799
POPTR_825877
RCU: RCOM_0189410 RCOM_1049540 RCOM_1488780 RCOM_1597800
VVI: 100242358 100244595 100255753 100262786
OSA: 4326547(Os01g0742500) 4326776(Os01g0190400)
4339361(Os05g0522500) 4339420(Os05g0532600)
4342654(Os07g0197100) 4343113(Os07g0446800)
SBI: SORBI_03g003190 SORBI_03g034230 SORBI_03g045420 SORBI_09g005840
SORBI_09g026080
ZMA: 100170246 100192075(si946063f09) 100279587 100283735 100382676
PPP: PHYPADRAFT_228844(hxk1) PHYPADRAFT_228857(hxk2)
PHYPADRAFT_228859(hxk4) PHYPADRAFT_228860(hxk5)
PHYPADRAFT_228861(hxk6) PHYPADRAFT_228862(hxk7)
PHYPADRAFT_228864(hxk9) PHYPADRAFT_235449(hxk8)
CRE: CHLREDRAFT_21582(HXK1)
SCE: YCL040W(GLK1) YFR053C(HXK1) YGL253W(HXK2)
AGO: AGOS_AFR279C AGOS_AFR716C
KLA: KLLA0C01155g KLLA0D11352g
LTH: KLTH0F01144g KLTH0G00440g
DHA: DEHA2E06556g DEHA2F13992g
PIC: PICST_32526(NAG5) PICST_73701(GLK1) PICST_85453(HXK1)
PPA: PAS_chr1-4_0447 PAS_chr3_1192 PAS_chr4_0624
PGU: PGUG_00480 PGUG_00965 PGUG_02601
VPO: Kpol_2000p103 Kpol_2002p32 Kpol_507p3
LEL: LELG_03126 LELG_03305 LELG_03676
ZRO: ZYRO0E09878g ZYRO0F17864g
CAL: CaO19.13(GLK2) CaO19.1408(GLK3) CaO19.542(HXK2) CaO19.734(GLK1)
CTP: CTRG_00414 CTRG_03132 CTRG_03726
CDU: CD36_29870 CD36_32740
CGR: CAGL0A04829g CAGL0F00605g CAGL0H07579g
YLI: YALI0B22308g YALI0E15488g YALI0E20207g
CLU: CLUG_02103 CLUG_02911 CLUG_05574
SPO: SPAC24H6.04(hxk1) SPAC4F8.07c(hxk2)
NCR: NCU00575 NCU02542 NCU04728
PAN: PODANSg09944 PODANSg2983 PODANSg3980
MGR: MGCH7_ch7g833(MGG_ch7g833) MGG_00623(MG00623.4)
MGG_03041(MG03041.4) MGG_09289(MG09289.4)
FGR: FG00500.1 FG08399.1
ANI: AN7459.2 AN8689.2
AFM: AFUA_2G00450 AFUA_2G05910 AFUA_2G16330 AFUA_6G02230
AFUA_6G03980 AFUA_7G04040
AOR: AO090001000710 AO090120000109
ANG: An02g14380(hxk) An12g08610(GlkA) An13g00510
AFV: AFLA_073260 AFLA_130070
ACT: ACLA_005730 ACLA_068420 ACLA_096650 ACLA_098220
PCS: Pc20g13040 Pc22g08480 Pc22g23550
NFI: NFIA_025000 NFIA_032670 NFIA_048520 NFIA_050510 NFIA_082630
NFIA_091590
CIM: CIMG_00997 CIMG_04401 CIMG_05829
URE: UREG_00948 UREG_04499
SSL: SS1G_01273 SS1G_05407 SS1G_12834
BFU: BC1G_05322 BC1G_12086 BC1G_12178
PNO: SNOG_09534 SNOG_10832 SNOG_15620
CNE: CNB02660 CNH01400
CNB: CNBB3020 CNBL1350
LBC: LACBIDRAFT_184098 LACBIDRAFT_312018
MPR: MPER_06863 MPER_13256
UMA: UM02173.1 UM03093.1
MGL: MGL_1289
EHI: EHI_098290(77.t00021) EHI_098560(19.t00020)
EDI: EDI_295250
PFA: PFF1155w
PFD: PFDG_04244
PFH: PFHG_01142
PYO: PY02030
PCB: PC301118.00.0
PBE: PB000727.00.0
PKN: PKH_112550
PVX: PVX_114315
TAN: TA19800 TA19810
TPV: TP01_0043 TP01_0045
BBO: BBOV_I000860(16.m00773)
CPV: cgd6_3800
CHO: Chro.60435
TGO: TGME49_065450
TBR: Tb10.70.5800 Tb10.70.5820
TCR: 508951.20 510121.20
LMA: LmjF21.0240 LmjF21.0250
LIF: LinJ21.0140 LinJ21.0150
LBZ: LbrM21_V2.0310
CCE: Ccel_3221
DRM: Dred_1810
DAE: Dtox_3946
HMO: HM1_0763
CLO: HMPREF0868_1026
TPA: TP0505
TPP: TPASS_0505(hxk)
TDE: TDE2469
 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:16748250]
Bailey K, Webb EC.
Purification of yeast hexokinase and its reaction with
betabeta'-dichlorodiethyl sulphide.
Biochem. J. 42 (1948) 60-8.
Saccharomyces cerevisiae [GN:sce] |
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Reference
Authors
Title
Journal
|
2
Berger, L., Slein, M.W., Colowick, S.P. and Cori, C.F.
Isolation of hexokinase from baker's yeast.
J. Gen. Physiol. 29 (1946) 379-391. |
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Reference
Authors
Title
Journal
|
3
Kunitz, M. and McDonald, M.R.
Crystalline hexokinase (heterophosphatase). Method of isolation and
properties.
J. Gen. Physiol. 29 (1946) 393-412. |
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Reference
Authors
Title
Journal
Organism
|
4 [PMID:7048063]
Pollard-Knight D, Cornish-Bowden A.
Mechanism of liver glucokinase.
Mol. Cell. Biochem. 44 (1982) 71-80.
Rattus norvegicus [GN:rno], Bos taurus [GN:bta] |
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Reference
Authors
Title
Journal
|
5 [PMID:233226]
Ureta T, Radojkovic J, Lagos R, Guixe V, Nunez L.
Phylogenetic and ontogenetic studies of glucose phosphorylating
isozymes of vertebrates.
Arch. Biol. Med. Exp. (Santiago). 12 (1979) 587-604. |
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Reference
Authors
Title
Journal
Organism
|
6 [PMID:6477520]
Cardenas ML, Rabajille E, Niemeyer H.
Fructose is a good substrate for rat liver 'glucokinase' (hexokinase
D).
Biochem. J. 222 (1984) 363-70.
Rattus norvegicus [GN:rno] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.1.1
IUBMB Enzyme Nomenclature: 2.7.1.1
ExPASy - ENZYME nomenclature database: 2.7.1.1
BRENDA, the Enzyme Database: 2.7.1.1
CAS: 9001-51-8 |
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