KEGG   ENZYME: 2.7.1.127Help
Entry
EC 2.7.1.127                Enzyme                                 
Name
inositol-trisphosphate 3-kinase;
1D-myo-inositol-trisphosphate 3-kinase;
Ins(1,4,5)P3 3-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase
Reaction(IUBMB)
ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate [RN:R03433]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 1,4,5-trisphosphate [CPD:C01245]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5-tetrakisphosphate [CPD:C01272]
Comment
Activated by Ca2+. Three isoforms have been shown to exist [3].
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K00911  
1D-myo-inositol-triphosphate 3-kinase
Genes
HSA: 
3706(ITPKA) 3707(ITPKB) 80271(ITPKC)
PTR: 
453349(ITPKA) 457789(ITPKB) 468885(ITPKC)
PPS: 
100974308(ITPKB) 100976198(ITPKC) 100988859(ITPKA)
GGO: 
PON: 
100448277(ITPKC) 100453141(ITPKA) 100460190(ITPKB)
MCC: 
698185(ITPKB) 703722 710541(ITPKA)
MMU: 
228550(Itpka) 233011(Itpkc) 320404(Itpkb)
RNO: 
308451(Itpkc) 54260(Itpkb) 81677(Itpka)
CFA: 
487507(ITPKA) 490383(ITPKB) 612489(ITPKC)
AML: 
FCA: 
101084366(ITPKA) 101087547(ITPKB) 101088202(ITPKC)
BTA: 
534051(ITPKC) 540877(ITPKB) 615813(ITPKA)
SSC: 
100516235(ITPKA) 100524376(ITPKC)
ECB: 
100058602 100064775(ITPKC) 100147269
MDO: 
100018241 100026399(ITPKB) 100027749(ITPKA)
SHR: 
100915595(ITPKC) 100928977(ITPKB) 100935263(ITPKA)
OAA: 
100082376
GGA: 
395694(ITPKA) 416743(ITPKB)
MGP: 
100542169 100546133
TGU: 
100219110(ITPKA) 100224788(ITPKB)
ACS: 
100554212 100564166
XLA: 
494865(itpkc)
XTR: 
100486229 100497340 779709(itpkc)
DRE: 
562919(itpkca) 563019(itpkb) 564528
TRU: 
101061932 101066433 101066895
OLA: 
101157020 101160679 101171378
BFO: 
BRAFLDRAFT_223625 BRAFLDRAFT_269201
CIN: 
100182922
SPU: 
590949
DME: 
Dmel_CG34359(IP3K2) Dmel_CG4026(IP3K1)
DPO: 
Dpse_GA14058 Dpse_GA17884
DAN: 
Dana_GF19401 Dana_GF22812
DER: 
Dere_GG10056 Dere_GG17771
DPE: 
Dper_GL18935 Dper_GL26915
DSE: 
Dsec_GM11620 Dsec_GM17705
DSI: 
Dsim_GD17114 Dsim_GD23630
DWI: 
Dwil_GK20073 Dwil_GK24866
DYA: 
Dyak_GE17061 Dyak_GE18870
DGR: 
Dgri_GH12819 Dgri_GH13823
DMO: 
Dmoj_GI15923 Dmoj_GI20140
DVI: 
Dvir_GJ13525 Dvir_GJ16830
AGA: 
AgaP_AGAP002194
AAG: 
AaeL_AAEL010766 AaeL_AAEL013183
CQU: 
CpipJ_CPIJ001991 CpipJ_CPIJ012003
AME: 
409943(Ip3k) 413817
NVI: 
100120589(NV16730)
TCA: 
657796 661862
API: 
100164481 100165797
PHU: 
Phum_PHUM233490 Phum_PHUM596370
ISC: 
IscW_ISCW014946 IscW_ISCW015457
TSP: 
Tsp_11747
SMM: 
Smp_140840
NVE: 
NEMVE_v1g88290
HMG: 
100214171
TAD: 
TRIADDRAFT_27232
AQU: 
100634062
MBR: 
MONBRDRAFT_24063 MONBRDRAFT_30714
 » show all
Taxonomy
Reference
1  [PMID:3487541]
  Authors
Hansen CA, Mah S, Williamson JR.
  Title
Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver.
  Journal
J. Biol. Chem. 261 (1986) 8100-3.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:3010126]
  Authors
Irvine RF, Letcher AJ, Heslop JP, Berridge MJ.
  Title
The inositol tris/tetrakisphosphate pathway--demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues.
  Journal
Nature. 320 (1986) 631-4.
Reference
3  [PMID:11331907]
  Authors
Irvine RF, Schell MJ.
  Title
Back in the water: the return of the inositol phosphates.
  Journal
Nat. Rev. Mol. Cell. Biol. 2 (2001) 327-38.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
106283-10-7
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