KEGG   ENZYME: 2.7.1.134Help
Entry
EC 2.7.1.134                Enzyme                                 

Name
inositol-tetrakisphosphate 1-kinase;
1D-myo-inositol-tetrakisphosphate 1-kinase;
inositol-trisphosphate 6-kinase;
1D-myo-inositol-trisphosphate 6-kinase;
ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase;
inositol-trisphosphate 5-kinase;
1D-myo-inositol-trisphosphate 5-kinase;
ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase
Reaction(IUBMB)
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R03479]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 3,4,5,6-tetrakisphosphate [CPD:C04520]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284]
Comment
This enzyme also phosphorylates Ins(1,3,4)P3 on O-5 and O-6. The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. It can also catalyse an isomerization between Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP.
History
EC 2.7.1.134 created 1990, (EC 2.7.1.133 created 1989, incorporated 2002; EC 2.7.1.139 created 1992, incorporated 2002), modified 2002
Pathway
Inositol phosphate metabolism
Orthology
K00913  
inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase
Genes
HSA: 
3705(ITPK1)
PTR: 
453121(ITPK1)
PPS: 
100980755(ITPK1)
GGO: 
101134664(ITPK1)
PON: 
100448118(ITPK1)
MCC: 
698756(ITPK1)
MCF: 
102119398(ITPK1)
MMU: 
217837(Itpk1)
RNO: 
500709(Itpk1)
CGE: 
HGL: 
101700462(Itpk1)
TUP: 
102479480(ITPK1)
CFA: 
490591(ITPK1)
AML: 
FCA: 
101087672(ITPK1)
PTG: 
102951160(ITPK1)
BTA: 
518488(ITPK1)
BOM: 
102279411(ITPK1)
PHD: 
102333268(ITPK1)
CHX: 
102183460(ITPK1)
SSC: 
100152339(ITPK1)
CFR: 
102508931(ITPK1)
ECB: 
100063828(ITPK1)
MYB: 
102246792(ITPK1)
MYD: 
PALE: 
102877958(ITPK1)
MDO: 
100014342(ITPK1)
SHR: 
OAA: 
100079832(ITPK1)
GGA: 
423421(ITPK1)
MGP: 
TGU: 
100222999(ITPK1)
FAB: 
101819235(ITPK1)
PHI: 
102106037(ITPK1)
APLA: 
101801656(ITPK1)
FPG: 
101920131(ITPK1)
FCH: 
102048369(ITPK1)
CLV: 
102088692(ITPK1)
ASN: 
102373418(ITPK1)
PSS: 
102452019(ITPK1)
CMY: 
ACS: 
XLA: 
379828(itpk1)
XTR: 
549890(itpk1)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
SPU: 
AME: 
551726(GB12674)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
SMM: 
NVE: 
HMG: 
TAD: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0001s02250g POPTR_0003s09290g(POPTRDRAFT_852723) POPTR_0005s19370g(POPTRDRAFT_209085) POPTR_0009s08800g(POPTRDRAFT_722456)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0466400-01(Os02g0466400) Os03t0230500-01(Os03g0230500) Os03t0726200-01(Os03g0726200) Os10t0103800-01(Os10g0103800) Os10t0576100-01(Os10g0576100)
OBR: 
BDI: 
SBI: 
SORBI_01g009550(SORBIDRAFT_01g009550) SORBI_01g027420(SORBIDRAFT_01g027420) SORBI_01g028090(SORBIDRAFT_01g028090) SORBI_01g042010(SORBIDRAFT_01g042010) SORBI_04g017450(SORBIDRAFT_04g017450)
ZMA: 
SITA: 
ATR: 
s00048p00050940(AMTR_s00048p00050940) s00056p00164210(AMTR_s00056p00164210)
SMO: 
PPP: 
CRE: 
VCN: 
MIS: 
CSL: 
CVR: 
GSL: 
CCP: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_02662(ITPK1)
EHI: 
EHI_042120(11.t00022) EHI_100310(151.t00008)
EDI: 
ACAN: 
TET: 
PTM: 
PTI: 
TPS: 
PIF: 
GTT: 
TVA: 
 » show all
Taxonomy
Reference
1  [PMID:2829850]
  Authors
Stephens LR, Hawkins PT, Morris AJ, Downes PC.
  Title
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase.
  Journal
Biochem. J. 249 (1988) 283-92.
  Organism
Mus musculus, Rattus norvegicus
Reference
2  [PMID:3497156]
  Authors
Balla T, Guillemette G, Baukal AJ, Catt KJ.
  Title
Metabolism of inositol 1,3,4-trisphosphate to a new tetrakisphosphate isomer in angiotensin-stimulated adrenal glomerulosa cells.
  Journal
J. Biol. Chem. 262 (1987) 9952-5.
  Organism
Bos taurus
Reference
3  [PMID:2823793]
  Authors
Shears SB, Parry JB, Tang EK, Irvine RF, Michell RH, Kirk CJ.
  Title
Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate.
  Journal
Biochem. J. 246 (1987) 139-47.
  Organism
Rattus norvegicus
Reference
4  [PMID:2584198]
  Authors
Shears SB.
  Title
The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase.
  Journal
J. Biol. Chem. 264 (1989) 19879-86.
  Organism
Rattus norvegicus
Reference
5  [PMID:11042108]
  Authors
Yang X, Shears SB.
  Title
Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.
  Journal
Biochem. J. 351 Pt 3 (2000) 551-5.
  Organism
Homo sapiens
  Sequence
[hsa:3705]
Reference
6  [PMID:11909533]
  Authors
Ho MW, Yang X, Carew MA, Zhang T, Hua L, Kwon YU, Chung SK, Adelt S, Vogel G, Riley AM, Potter BV, Shears SB.
  Title
Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.
  Journal
Curr. Biol. 12 (2002) 477-82.
  Organism
Homo sapiens
  Sequence
[hsa:3705]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
187175-98-0

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